Sfoglia per Autore
The dual role of mitochondrial superoxide in arsenite toxicity: Signaling at the boundary between apoptotic commitment and cytoprotection
2018 Fiorani, Mara; Guidarelli, Andrea; Capellacci, Valentina; Cerioni, Liana; Crinelli, Rita; Cantoni, Orazio
Differentiation of Promonocytic U937 Cells to Monocytes Is Associated with Reduced Mitochondrial Transport of Ascorbic Acid
2018 Scotti, Maddalena; Fiorani, Mara; Guidarelli, Andrea; Cantoni, Orazio
Mitochondrial Uptake and Accumulation of Vitamin C: What Can We Learn From Cell Cultures Studies?
2018 Cantoni, Orazio; Guidarelli, Andrea; Fiorani, Mara
Intramitochondrial Ascorbic Acid Enhances the Formation of Mitochondrial Superoxide Induced by Peroxynitrite via a Ca(2+)-Independent Mechanism
2017 Guidarelli, Andrea; Cerioni, Liana; Fiorani, Mara; Cantoni, Orazio
Arsenite induces DNA damage via mitochondrial ROS and induction of mitochondrial permeability transition
2017 Guidarelli, Andrea; Fiorani, Mara; Cerioni, Liana; Scotti, Maddalena; Cantoni, Orazio
The study of the mechanism of arsenite toxicity in respiration-deficient cells reveals that NADPH oxidase-derived superoxide promotes the same downstream events mediated by mitochondrial superoxide in respiration-proficient cells
2016 Guidarelli, Andrea; Fiorani, Mara; Carloni, Silvia; Cerioni, Liana; Balduini, Walter; Cantoni, Orazio
Mitochondrial ascorbic acid prevents mitochondrial O2.- formation, an event critical for U937 cell apoptosis induced by arsenite through both autophagic-dependent and independent mechanisms
2016 Guidarelli, Andrea; Carloni, Silvia; Balduini, Walter; Fiorani, Mara; Cantoni, Orazio
Intracellular dehydroascorbic acid inhibits SVCT2-dependent transport of ascorbic acid in mitochondria
2015 Fiorani, Mara; Azzolini, Catia; Guidarelli, Andrea; Cerioni, Liana; Scotti, Maddalena; Cantoni, Orazio
The mitochondrial transporter of ascorbic acid functions with high affinity in the presence of low millimolar concentrations of sodium and in the absence of calcium and magnesium
2015 Fiorani, Mara; Catia, Azzolini; Cerioni, Liana; Scotti, Maddalena; Guidarelli, Andrea; Ciacci, Caterina; Cantoni, Orazio
U937 cell apoptosis induced by arsenite is prevented by low concentrations of mitochondrial ascorbic acid with hardly any effect mediated by the cytosolic fraction of the vitamin
2015 Guidarelli, Andrea; Fiorani, Mara; Catia, Azzolini; Cerioni, Liana; Scotti, Maddalena; Cantoni, Orazio
Novel SETX variants in a patient with ataxia, neuropathy, and oculomotor apraxia are associated with normal sensitivity to oxidative DNA damaging agents
2014 Chiara, Vantaggiato; Cantoni, Orazio; Guidarelli, Andrea; Romina, Romaniello; Andrea, Citterio; Filippo, Arrigoni; Chiara, Doneda; Marianna, Castelli; Giovanni, Airoldi; Nereo, Bresolin; Renato, Borgatti; Maria Teresa, Bassi
A novel biological role of dehydroascorbic acid: Inhibition of Na+-dependent transport of ascorbic acid.
2014 Fiorani, Mara; Azzolini, Catia; Guidarelli, Andrea; Cerioni, Liana; Cantoni, Orazio
Mitochondrial ascorbic acid is responsible for enhanced susceptibility of U937 cells to the toxic effects of peroxynitrite
2014 Guidarelli, Andrea; Cerioni, Liana; Fiorani, Mara; Azzolini, Catia; Cantoni, Orazio
Sodium-dependent transport of ascorbic acid in U937 cell mitochondria.
2013 Azzolini, Catia; Fiorani, Mara; Cerioni, Liana; Guidarelli, Andrea; Cantoni, Orazio
Superoxide dictates the mode of U937 cell ascorbic acid uptake and prevents the enhancing effects of the vitamin to otherwise non-toxic levels of reactive oxygen/nitrogen species
2013 Fiorani, Mara; Azzolini, Catia; Cerioni, Liana; Guidarelli, Andrea; Cantoni, Orazio
Studies with low micromolar levels of ascorbic and dehydroascorbic acid fail to unravel a preferential route for vitamin C uptake and accumulation in U937 cells
2012 Azzolini, Catia; Fiorani, Mara; Guidarelli, Andrea; Cantoni, Orazio
A novel nonsense mutation in the APTX gene associated with delayed DNA single-strand break removal fails to enhance sensitivity to different genotoxic agents.
2011 Crimella, C; Cantoni, Orazio; Guidarelli, Andrea; Vantaggiato, C; Martinuzzi, A; Fiorani, Mara; Azzolini, Catia; Orso, G; Bresolin, N; Bassi, M. T.
Characterization of two novel SETX mutations in AOA2 patients reveals aspects of the pathophysiological role of senataxin.
2010 Airoldi, G; Guidarelli, Andrea; Cantoni, Orazio; Panzeri, C; Vantaggiato, C; Bonato, S; GRAZIA D'ANGELO, M; Falcone, S; DE PALMA, C; Tonelli, A; Crimella, C; Bondioni, S; Bresolin, N; Clementi, E; Bassi, Mt
Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid
2010 Fiorani, Mara; Guidarelli, Andrea; Blasa, Manuela; Azzolini, Catia; Candiracci, Manila; Piatti, Elena; Cantoni, Orazio
A novel mechanism, uniquely dependent on mitochondrial calcium accumulation, whereby peroxynitrite promotes formation of superoxide/hydrogen peroxide and the ensuing strand scission of genomic DNA
2010 Guidarelli, Andrea; Fiorani, Mara; Azzolini, Catia; Cantoni, Orazio
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