A novel class of annelated 1,4-benzodiazepines was synthesized by 1,3-dipolar cycloaddition of suitable nitrilimines to the C=N bond of the benzodiazepine ring. Structures and conformations of adducts have been assigned by means of spectroscopic measurements. The additional heterocyclic nucleus has been found to influence dramatically the conformational mobility of the heptatomic ring.
Novel fused-ring derivatives of 1,4-benzodiazepine system: synthesis of tetrahydro-1H-s-triazolo[4,3-d][1,4]benzodiazepines
ZAPPIA, GIOVANNI
1985
Abstract
A novel class of annelated 1,4-benzodiazepines was synthesized by 1,3-dipolar cycloaddition of suitable nitrilimines to the C=N bond of the benzodiazepine ring. Structures and conformations of adducts have been assigned by means of spectroscopic measurements. The additional heterocyclic nucleus has been found to influence dramatically the conformational mobility of the heptatomic ring.File in questo prodotto:
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