Synthesis of enantiomerically pure compounds by the use of “man made” chiral inducers has the greatest potential for general asymmetric synthesis since, in principle, no limits exist in terms of their molecular design. This chapter covers the syntheses and uses of enantiopure 1,2- and 1,3-C2-symmetric diols as chiral inducers for diastereoselective reactions, as well as the prepa-ration and applications of the axially chiral 1,1′ binaphthalene-2,2′-diol (BINOL) structure and its derivatives. The interest for these “privileged ligands” is due to their peculiar steric and electronic properties, able to drive the stereochemical course of important chemical reactions in high levels of enantioselectivity.
Non-Chiral Pool Derived Synthetic Auxiliaries: Use of C2-Symmetric Chiral Diols
ZAPPIA, GIOVANNI
2012
Abstract
Synthesis of enantiomerically pure compounds by the use of “man made” chiral inducers has the greatest potential for general asymmetric synthesis since, in principle, no limits exist in terms of their molecular design. This chapter covers the syntheses and uses of enantiopure 1,2- and 1,3-C2-symmetric diols as chiral inducers for diastereoselective reactions, as well as the prepa-ration and applications of the axially chiral 1,1′ binaphthalene-2,2′-diol (BINOL) structure and its derivatives. The interest for these “privileged ligands” is due to their peculiar steric and electronic properties, able to drive the stereochemical course of important chemical reactions in high levels of enantioselectivity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
