The present method provides highly functionalized 1,3-oxathioles 4 through an unusual base-promoted [4+1] annulation between α,α’-dioxothione (DT) 2a, generated in situ from phthalimide precursor (DTPht) 1a and 1,2-diaza-1,3-dienes (DDs) 3. An intriguing scaffold 5 comprised of spiro-fused oxathiole and pyrazolone components was also obtained in moderate yield.
Synthesis of Highly Functionalized 1,3-Oxathiazoles via an Unusual [4+1] Annulation alpha,alpha'-Dioxothione with 1,2-Diaza-1,3-dienes
ATTANASI, ORAZIO ANTONIO;FAVI, GIANFRANCOWriting – Original Draft Preparation
;MANTELLINI, FABIO;MOSCATELLI, GIADA;
2012
Abstract
The present method provides highly functionalized 1,3-oxathioles 4 through an unusual base-promoted [4+1] annulation between α,α’-dioxothione (DT) 2a, generated in situ from phthalimide precursor (DTPht) 1a and 1,2-diaza-1,3-dienes (DDs) 3. An intriguing scaffold 5 comprised of spiro-fused oxathiole and pyrazolone components was also obtained in moderate yield.File in questo prodotto:
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