The base (NaH)-promoted Michael addition of N-arylhydrazones (AHs) with 1,2-diaza-1,3-dienes (DDs) produces unprecedented β-azohydrazone adducts. Strategically, the use of AHs as acyl anion equivalents (d1 synthon) and DDs as α-electrophiles (a2 synthon) of carbonyl compounds open the way to two important classes of pyrazole compounds.
Divergent Construction of Pyrazoles via Michael Addition of N‑Arylhydrazones to 1,2-Diaza-1,3-dienes
MANTENUTO, SERENA;MANTELLINI, FABIO;ATTANASI, ORAZIO ANTONIO;FAVI, GIANFRANCO
2015
Abstract
The base (NaH)-promoted Michael addition of N-arylhydrazones (AHs) with 1,2-diaza-1,3-dienes (DDs) produces unprecedented β-azohydrazone adducts. Strategically, the use of AHs as acyl anion equivalents (d1 synthon) and DDs as α-electrophiles (a2 synthon) of carbonyl compounds open the way to two important classes of pyrazole compounds.File in questo prodotto:
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