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Intramitochondrial Ascorbic Acid Enhances the Formation of Mitochondrial Superoxide Induced by Peroxynitrite via a Ca(2+)-Independent Mechanism 1-gen-2017 Guidarelli, Andrea; Cerioni, Liana; Fiorani, Mara; Cantoni, Orazio
Arsenite induces DNA damage via mitochondrial ROS and induction of mitochondrial permeability transition 1-gen-2017 Guidarelli, Andrea; Fiorani, Mara; Cerioni, Liana; Scotti, Maddalena; Cantoni, Orazio
Mitochondrial ascorbic acid prevents mitochondrial O2.- formation, an event critical for U937 cell apoptosis induced by arsenite through both autophagic-dependent and independent mechanisms 1-gen-2016 Guidarelli, Andrea; Carloni, Silvia; Balduini, Walter; Fiorani, Mara; Cantoni, Orazio
The study of the mechanism of arsenite toxicity in respiration-deficient cells reveals that NADPH oxidase-derived superoxide promotes the same downstream events mediated by mitochondrial superoxide in respiration-proficient cells 1-gen-2016 Guidarelli, Andrea; Fiorani, Mara; Carloni, Silvia; Cerioni, Liana; Balduini, Walter; Cantoni, Orazio
U937 cell apoptosis induced by arsenite is prevented by low concentrations of mitochondrial ascorbic acid with hardly any effect mediated by the cytosolic fraction of the vitamin 1-gen-2015 Guidarelli, Andrea; Fiorani, Mara; Catia, Azzolini; Cerioni, Liana; Scotti, Maddalena; Cantoni, Orazio
Intracellular dehydroascorbic acid inhibits SVCT2-dependent transport of ascorbic acid in mitochondria 1-gen-2015 Fiorani, Mara; Azzolini, Catia; Guidarelli, Andrea; Cerioni, Liana; Scotti, Maddalena; Cantoni, Orazio
The mitochondrial transporter of ascorbic acid functions with high affinity in the presence of low millimolar concentrations of sodium and in the absence of calcium and magnesium 1-gen-2015 Fiorani, Mara; Catia, Azzolini; Cerioni, Liana; Scotti, Maddalena; Guidarelli, Andrea; Ciacci, Caterina; Cantoni, Orazio
Mitochondrial ascorbic acid is responsible for enhanced susceptibility of U937 cells to the toxic effects of peroxynitrite 1-gen-2014 Guidarelli, Andrea; Cerioni, Liana; Fiorani, Mara; Azzolini, Catia; Cantoni, Orazio
A novel biological role of dehydroascorbic acid: Inhibition of Na+-dependent transport of ascorbic acid. 1-gen-2014 Fiorani, Mara; Azzolini, Catia; Guidarelli, Andrea; Cerioni, Liana; Cantoni, Orazio
Sodium-dependent transport of ascorbic acid in U937 cell mitochondria. 1-gen-2013 Azzolini, Catia; Fiorani, Mara; Cerioni, Liana; Guidarelli, Andrea; Cantoni, Orazio
Superoxide dictates the mode of U937 cell ascorbic acid uptake and prevents the enhancing effects of the vitamin to otherwise non-toxic levels of reactive oxygen/nitrogen species 1-gen-2013 Fiorani, Mara; Azzolini, Catia; Cerioni, Liana; Guidarelli, Andrea; Cantoni, Orazio
Studies with low micromolar levels of ascorbic and dehydroascorbic acid fail to unravel a preferential route for vitamin C uptake and accumulation in U937 cells 1-gen-2012 Azzolini, Catia; Fiorani, Mara; Guidarelli, Andrea; Cantoni, Orazio
A moderate decline in U937 cell GSH levels triggers PI3 kinase/Akt-dependent Bad phosphorylation, thereby preventing an otherwise prompt apoptotic response 1-gen-2012 Cerioni, Liana; Fiorani, Mara; Azzolini, Catia; Cantoni, Orazio
A novel nonsense mutation in the APTX gene associated with delayed DNA single-strand break removal fails to enhance sensitivity to different genotoxic agents. 1-gen-2011 Crimella, C; Cantoni, Orazio; Guidarelli, Andrea; Vantaggiato, C; Martinuzzi, A; Fiorani, Mara; Azzolini, Catia; Orso, G; Bresolin, N; Bassi, M. T.
A novel mechanism, uniquely dependent on mitochondrial calcium accumulation, whereby peroxynitrite promotes formation of superoxide/hydrogen peroxide and the ensuing strand scission of genomic DNA 1-gen-2010 Guidarelli, Andrea; Fiorani, Mara; Azzolini, Catia; Cantoni, Orazio
Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid 1-gen-2010 Fiorani, Mara; Guidarelli, Andrea; Blasa, Manuela; Azzolini, Catia; Candiracci, Manila; Piatti, Elena; Cantoni, Orazio
Oxidative damage induced by herbicides is mediated by thiol oxidation and hydroperoxides production 1-gen-2010 Braconi, D; Bernardini, G; Fiorani, Mara; Azzolini, Catia; Marzocchi, B; Proietti, F; Collodel, G; Santucci, A.
Differentiation-associated loss of ryanodine receptors: a strategy adopted by monocytes/macrophages to prevent the DNA single-strand breakage induced by peroxynitrite. 1-gen-2009 Guidarelli, Andrea; Cerioni, Liana; Fiorani, Mara; Cantoni, Orazio
Susceptibility of rat astrocytes to DNA strand scission induced by activation of NADPH oxidase and collateral resistance to the effects of peroxynitrite. 1-gen-2008 Guidarelli, Andrea; Palomba, Letizia; Fiorani, Mara; Cantoni, Orazio
Interactions between ascorbic acid and flavonoids in the redox regulation of the intra-extra cellular milieu 1-gen-2006 Fiorani, Mara
Mostrati risultati da 21 a 40 di 78
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