Effect of exercise in Breast Cancer and its association with tumor characteristics, risk factors for recurrence and lifestyle

Triple-negative breast cancer (TNBC) does not express estrogen receptors, progesterone receptors, or human epidermal growth factor receptor 2, and it is characterized by its aggressive nature, lack of targeted therapies and early peak of recurrence. Recent observational research suggests that inactivity is associated with an increased risk of breast cancer (BC) including the Triple Negative subtype. Little is known about the potential driving molecular events for each subtype of BC and the mechanisms through which exercise yields protective effects against disease progression and recurrence risk. The present thesis focuses on the protective effects of exercise against TNBC through the induction of biochemical metabolic system modifications able to reduce the cell proliferation of BC.