Intramolecular 1,3 dipolar cycloaddition: a powerful tool to synthetize fused heterocycles

In the first part of this thesis, “click chemistry” is explored as a powerful tool to synthetize fused heterocyclic compounds, as novel pharmacophores, starting from chiral (S)-β-amino acid. Particularly, all the intramolecular cycloadditions are run under catalyst free conditions. In the second part, the one-pot reaction between oxetan-3-ols and diols is explored. This diversity-oriented synthesis approach explores a range of oxetane electrophiles, and a range of bisnucleophiles to generate diverse 1,4-dioxanes of value to medicinal chemistry.