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Arsenite induces DNA damage via mitochondrial ROS and induction of mitochondrial permeability transition, file e18b865d-68b8-1ee6-e053-3a05fe0ae544
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217
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U937 cell apoptosis induced by arsenite is prevented by low concentrations of mitochondrial ascorbic acid with hardly any effect mediated by the cytosolic fraction of the vitamin, file e18b865d-614a-1ee6-e053-3a05fe0ae544
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122
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Mitochondrial Uptake and Accumulation of Vitamin C: What Can We Learn From Cell Cultures Studies?, file e18b865d-7a4a-1ee6-e053-3a05fe0ae544
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97
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Mitochondrial ascorbic acid prevents mitochondrial O2.- formation, an event critical for U937 cell apoptosis induced by arsenite through both autophagic-dependent and independent mechanisms, file e18b865d-6bcc-1ee6-e053-3a05fe0ae544
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78
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Calcium signals between the ryanodine receptor- and mitochondria critically regulate the effects of arsenite on mitochondrial superoxide formation and on the ensuing survival vs apoptotic signaling, file e18b865c-ad1b-1ee6-e053-3a05fe0ae544
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68
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The dual role of mitochondrial superoxide in arsenite toxicity: Signaling at the boundary between apoptotic commitment and cytoprotection, file e18b865d-6769-1ee6-e053-3a05fe0ae544
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33
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Intracellular dehydroascorbic acid inhibits SVCT2-dependent transport of ascorbic acid in mitochondria, file e18b865d-7950-1ee6-e053-3a05fe0ae544
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30
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Quercetin prevents DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide: free radical scavenging versus iron chelating mechanism., file e18b865b-78c4-1ee6-e053-3a05fe0ae544
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25
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The mitochondrial transporter of ascorbic acid functions with high affinity in the presence of low millimolar concentrations of sodium and in the absence of calcium and magnesium, file e18b865d-60d0-1ee6-e053-3a05fe0ae544
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25
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The arachidonate-dependent survival signaling preventing toxicity in monocytes/macrophages exposed to peroxynitrite., file e18b865c-461f-1ee6-e053-3a05fe0ae544
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22
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Cross-Talk Between NO Synthase Isoforms in Neuro-Inflammation: Possible Implications in HIV-Associated Neurocognitive Disorders, file e18b865c-07cf-1ee6-e053-3a05fe0ae544
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19
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The study of the mechanism of arsenite toxicity in respiration-deficient cells reveals that NADPH oxidase-derived superoxide promotes the same downstream events mediated by mitochondrial superoxide in respiration-proficient cells, file e18b865b-da46-1ee6-e053-3a05fe0ae544
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17
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Cytotoxic impact of DNA single vs double strand breaks in oxidatively injured cells, file e18b865b-7bc8-1ee6-e053-3a05fe0ae544
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15
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The L-histidine-mediated enhancement of hydrogen peroxide-induced DNA double strand breakage and cytotoxicity does not involve metabolic processes., file e18b865b-78d4-1ee6-e053-3a05fe0ae544
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13
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Indirect Mechanisms of DNA Strand Scission by Peroxynitrite, file e18b865c-170c-1ee6-e053-3a05fe0ae544
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12
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Arsenite-induced mitochondrial superoxide formation: time and concentration requirements for the effects of the metalloid on the endoplasmic reticulum and mitochondria, file e18b865d-0d2b-1ee6-e053-3a05fe0ae544
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12
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Apoptosis and necrosis following exposure of U937 cells to increasing concentrations of hydrogen peroxide: the effect of the poly(ADP-ribose)polymerase inhibitor 3-aminobenzamide., file e18b865b-7c21-1ee6-e053-3a05fe0ae544
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11
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Endogenous and exogenous nitric oxide enhance the DNA strand scission induced by tert-butylhydroperoxide in PC12 cells via peroxynitrite-dependent and independent mechanisms, respectively., file e18b865b-78ca-1ee6-e053-3a05fe0ae544
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10
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Mitochondrial Uptake and Accumulation of Vitamin C: What Can We Learn From Cell Cultures Studies?, file e18b865c-9e30-1ee6-e053-3a05fe0ae544
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10
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Temporal correlation of morphological and biochemical changes with the recruitment of different mechanisms of reactive oxygen species formation during human SW872 cell adipogenic differentiation, file e18b865d-a188-1ee6-e053-3a05fe0ae544
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10
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Mitochondrial respiratory chain deficiency leads to overexpression of antioxidant enzymes., file e18b865b-78c5-1ee6-e053-3a05fe0ae544
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9
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Delayed formation of hydrogen peroxide mediates the lethal response evoked by peroxynitrite in U937 cells, file e18b865b-78c8-1ee6-e053-3a05fe0ae544
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9
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Arachidonic acid induces calcium-dependent mitochondrial formation of species promoting strand scission of genomic DNA, file e18b865b-78c9-1ee6-e053-3a05fe0ae544
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8
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Osmotically driven radial diffusion of single-stranded DNA fragments on an agarose bed as a convenient measure of DNA strand scission., file e18b865b-7bcf-1ee6-e053-3a05fe0ae544
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8
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The antioxidant butylated hydroxytoluene induces apoptosis in human U937 cells: the role of hydrogen peroxide and altered redox state., file e18b865b-7c22-1ee6-e053-3a05fe0ae544
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8
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Mitochondrial ascorbic acid prevents mitochondrial O2.- formation, an event critical for U937 cell apoptosis induced by arsenite through both autophagic-dependent and independent mechanisms, file e18b865b-cf81-1ee6-e053-3a05fe0ae544
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7
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Reduced mitochondrial formation of H(2)O(2) is responsible for resistance of dimethyl sufoxide differentiated U937 cells to peroxynitrite, file e18b865c-19e2-1ee6-e053-3a05fe0ae544
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7
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Isolation and preliminary characterization of a Chinese hamster ovary cell line with high-degree resistance to hydrogen peroxide., file e18b865b-78d2-1ee6-e053-3a05fe0ae544
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6
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The L-histidine-mediated enhancement of hydrogen peroxide-induced cytotoxicity is a general response in cultured mammalian cell lines and is always associated with the formation of DNA double strand breaks., file e18b865b-78d7-1ee6-e053-3a05fe0ae544
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6
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Products of the phospholipase A2 pathway mediate the dihydrorhodamine fluorescence response evoked by endogenous and exogenous peroxynitrite in PC12 cells., file e18b865b-79a9-1ee6-e053-3a05fe0ae544
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6
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Direct excision of 50 Kb pair DNA fragments from megabase-sized fragments produced during apoptotic cleavage of genomic DNA., file e18b865b-7bcc-1ee6-e053-3a05fe0ae544
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6
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Simultaneous determination of DNA double strand breaks and DNA fragment size in cultured mammalian cells exposed to hydrogen peroxide/histidine or etoposide with CHEF electrophoresis., file e18b865b-78d3-1ee6-e053-3a05fe0ae544
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5
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The induction/loss of the oxidant-resistant phenotype of Chinese hamster ovary (CHO) cell variants does not correlate with sensitivity to DNA single strand breakage by hydrogen peroxide., file e18b865b-78d8-1ee6-e053-3a05fe0ae544
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5
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L-glutamine prevents the L-histidine-mediated enhancement of hydrogen peroxide-induced cytotoxicity., file e18b865b-78d9-1ee6-e053-3a05fe0ae544
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5
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Modulation of the oxidative response of cultured mammalian cells by L-histidine., file e18b865b-79e3-1ee6-e053-3a05fe0ae544
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5
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Apoptosis of human lymphocytes in the absence or presence of internucleosomal DNA cleavage, file e18b865b-7bc9-1ee6-e053-3a05fe0ae544
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5
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tert-Butylhydroperoxide induces peroxynitrite-dependent mitochondrial permeability transition leading PC12 cells to necrosis, file e18b865b-7bd1-1ee6-e053-3a05fe0ae544
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5
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Development and characterization of hydrogen peroxide-resistant Chinese hamster ovary (CHO) cell variants--II. Relationships between non-protein sulfhydryl levels and the induction/stability of the oxidant-resistant phenotype., file e18b865d-239d-1ee6-e053-3a05fe0ae544
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5
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Calcium chelator Quin 2 prevents hydrogen-peroxide-induced DNA breakage and cytotoxicity., file e18b865b-78c2-1ee6-e053-3a05fe0ae544
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4
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Structural requirements for inhibitors of poly(ADP-ribose) polymerase., file e18b865b-78c3-1ee6-e053-3a05fe0ae544
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4
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Rotenone and pyruvate prevent the tert-butylhydroperoxide-induced necrosis of U937 cells and allow them to proliferate., file e18b865b-78c6-1ee6-e053-3a05fe0ae544
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4
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AG8 cells, which are highly resistant to hydrogen peroxide, display collateral sensitivity to the combination of hydrogen peroxide and L-histidine., file e18b865b-79e4-1ee6-e053-3a05fe0ae544
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4
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Evidence for separate mechanisms of cytotoxicity in mammalian cells treated with hydrogen peroxide in the absence or presence of L-histidine, file e18b865b-7bc7-1ee6-e053-3a05fe0ae544
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4
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The mitochondrial transporter of ascorbic acid functions with high affinity in the presence of low millimolar concentrations of sodium and in the absence of calcium and magnesium, file e18b865b-bfa2-1ee6-e053-3a05fe0ae544
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4
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ERK1/2 regulates two sequential steps promoting monocyte survival to peroxynitrite., file e18b865c-467b-1ee6-e053-3a05fe0ae544
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4
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Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells, file 3143391a-b1de-4f7d-bd40-bc9e4687225c
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3
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ERO1α primes the ryanodine receptor to respond to arsenite with concentration dependent Ca2+ release sequentially triggering two different mechanisms of ROS formation, file 8ead1475-1b4d-42a4-80ab-0733349b8f7c
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3
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Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide, file e18b865b-78c7-1ee6-e053-3a05fe0ae544
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3
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Hydrogen peroxide generated at the level of mitochondria in response to peroxynitrite promotes U937 cell death via inhibition of the cytoprotective signalling mediated by cytosolic phospholipase A2, file e18b865b-78ce-1ee6-e053-3a05fe0ae544
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3
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Peroxynitrite stimulates the activity of cytosolic phospholipase A2 in U937 cells: the extent of arachidonic acid formation regulates the balance between cell survival or death., file e18b865b-78d0-1ee6-e053-3a05fe0ae544
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3
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Cyclic GMP-dependent inhibition of acid sphingomyelinase by nitric oxide: an early step in protection against apoptosis., file e18b865b-78d1-1ee6-e053-3a05fe0ae544
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3
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Opposite effects of nitric oxide donors on DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide., file e18b865b-79e5-1ee6-e053-3a05fe0ae544
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3
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Plant-derived phenolic compounds prevent the DNA single-strand breakage and cytotoxicity induced by tert-butylhydroperoxide via an iron-chelating mechanism., file e18b865b-8364-1ee6-e053-3a05fe0ae544
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3
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Sodium-dependent transport of ascorbic acid in U937 cell mitochondria., file e18b865b-b3dd-1ee6-e053-3a05fe0ae544
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3
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Intracellular dehydroascorbic acid inhibits SVCT2-dependent transport of ascorbic acid in mitochondria, file e18b865c-1b7c-1ee6-e053-3a05fe0ae544
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3
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Low Concentrations of Arsenite Target the Intraluminal Inositol 1, 4, 5-Trisphosphate Receptor/Ryanodine Receptor Crosstalk to Significantly Elevate Intracellular Ca2, file e18b865c-a38b-1ee6-e053-3a05fe0ae544
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3
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The dual role of mitochondrial superoxide in arsenite toxicity: Signaling at the boundary between apoptotic commitment and cytoprotection, file e18b865d-6521-1ee6-e053-3a05fe0ae544
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3
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DOWNREGULATION OF NITRIC OXIDE FORMATION BY CYTOSOLIC PHOSPHOLIPASE A2-RELEASED ARACHIDONIC ACID., file e18b865b-78cf-1ee6-e053-3a05fe0ae544
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2
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A novel mechanism, uniquely dependent on mitochondrial calcium accumulation, whereby peroxynitrite promotes formation of superoxide/hydrogen peroxide and the ensuing strand scission of genomic DNA, file e18b865b-83b4-1ee6-e053-3a05fe0ae544
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2
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Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid, file e18b865b-84c8-1ee6-e053-3a05fe0ae544
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2
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Differentiation of Promonocytic U937 Cells to Monocytes Is Associated with Reduced Mitochondrial Transport of Ascorbic Acid, file e18b865c-8583-1ee6-e053-3a05fe0ae544
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2
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Electric and/or magnetic field effects on DNA structure and function in cultured human cells., file e18b865d-1def-1ee6-e053-3a05fe0ae544
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2
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Arsenite induces DNA damage via mitochondrial ROS and induction of mitochondrial permeability transition, file e18b865d-68b9-1ee6-e053-3a05fe0ae544
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2
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Crosstalk between ERO1α and ryanodine receptor in arsenite-dependent mitochondrial ROS formation, file e18b865d-ae15-1ee6-e053-3a05fe0ae544
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2
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Ascorbic Acid Route to the Endoplasmic Reticulum: Function and Role in Disease, file 362b7f78-2bb4-47a8-a164-b977d54c0160
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1
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Loss-of-rescue of Ryr1I4895T-related pathology by the genetic inhibition of the ER stress response mediator CHOP, file 796d8060-88fb-4b16-b6c4-3b512233544d
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1
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Arsenite enhances ERO1α expression via ryanodine receptor dependent and independent mechanisms, file 89ec3617-a1a2-463c-8597-334e6d5a3166
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1
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Hydrogen peroxide mediates the killing of U937 tumor cells elicited by pharmacologically attainable concentrations of ascorbic acid: cell death prevention by extracellular catalase or catalase from cocultured erythrocytes or fibroblasts, file e18b865b-78a1-1ee6-e053-3a05fe0ae544
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1
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U937 cell necrosis mediated by peroxynitrite is not caused by depletion of ATP and is prevented by arachidonate via an ATP-dependent mechanism., file e18b865b-79ea-1ee6-e053-3a05fe0ae544
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1
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NADH-linked substrate-mediated enhancement of mitochondrial calcium accumulation and DNA single-strand breakage elicited by tert-butylhydroperoxide: the source of the cation is a ryanodine-sensitive calcium store ., file e18b865c-15da-1ee6-e053-3a05fe0ae544
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1
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The mechanism of the nitric oxide-mediated enhancement of tert-butylhydroperoxide-induced DNA single strand breakage., file e18b865c-1795-1ee6-e053-3a05fe0ae544
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1
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The arachidonate-dependent cytoprotective signaling evoked by peroxynitrite is a general response of the monocyte/macrophage lineage, file e18b865c-19e5-1ee6-e053-3a05fe0ae544
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1
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Calcium-dependent mitochondrial formation of species mediating DNA single strand breakage in U937 cells exposed to sublethal concentrations of tert-butylhydroperoxide., file e18b865c-1a8f-1ee6-e053-3a05fe0ae544
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1
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Mechanism of the antimycin A-mediated enhancement of tert-butylhydroperoxide-induced single-strand breakage in DNA., file e18b865c-1a91-1ee6-e053-3a05fe0ae544
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1
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Pivotal role of superoxides generated in the mitochondrial respiratory chain in peroxynitrite-dependent activation of phospholipase A2., file e18b865c-1c32-1ee6-e053-3a05fe0ae544
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1
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Alternative mechanism for hydroperoxide-induced DNA single strand breakage., file e18b865c-1c7e-1ee6-e053-3a05fe0ae544
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1
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Stimulation of oxygen consumption promotes mitochondrial calcium accumulation, a process associated with, and causally linked to, enhanced formation of tert-butylhydroperoxide-induced DNA single-strand breaks., file e18b865c-2002-1ee6-e053-3a05fe0ae544
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1
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Pyruvate enhances DNA single-strand break formation while abolishing cytotoxicity in U937 cells exposed to tert-buytlhydroperoxide., file e18b865c-21a3-1ee6-e053-3a05fe0ae544
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1
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The compartmentalised nature of the mechanisms governing superoxide formation and scavenging in cells exposed to arsenite, file e18b865c-f71d-1ee6-e053-3a05fe0ae544
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1
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Hydrogen peroxide-and fetal bovine serum-induced DNA synthesis in vascular smooth muscle cells: positive and negative regulation by protein kinase C isoforms., file e18b865d-1dea-1ee6-e053-3a05fe0ae544
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1
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Superoxide dictates the mode of U937 cell ascorbic acid uptake and prevents the enhancing effects of the vitamin to otherwise non-toxic levels of reactive oxygen/nitrogen species, file e18b865d-26e3-1ee6-e053-3a05fe0ae544
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1
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Arsenite impinges on endoplasmic reticulum-mitochondria crosstalk to elicit mitochondrial ROS formation and downstream toxicity, file e18b865d-9bce-1ee6-e053-3a05fe0ae544
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1
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Mitochondrial ROS, ER Stress, and Nrf2 Crosstalk in the Regulation of Mitochondrial Apoptosis Induced by Arsenite, file e18b865d-c496-1ee6-e053-3a05fe0ae544
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1
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| Totale |
1.058 |