Previous studies have demonstrated that L-histidine increases the fragmentation of purified DNA induced by hydrogen per~xidel-~ as well as other effects produced by the oxidant in cultured mammalian cells, such as cytotoxicity,'J chromosomal aberrations: sister chromatid exchange~,~J~~ and the formation of r n i c r o n u ~ l e i . ~ ~ ~ ~ ~ The mechanism(s) involved in the enhancing effect of L-histidine on the deleterious effects of hydrogen peroxide is (are) still controversial, although various hypotheses have been made.- Summarized here are some of our recent results in studies to investigate the effects of L-histidine
Modulation of the oxidative response of cultured mammalian cells by L-histidine.
SESTILI, PIERO;GUIDARELLI, ANDREA;CANTONI, ORAZIO
1992
Abstract
Previous studies have demonstrated that L-histidine increases the fragmentation of purified DNA induced by hydrogen per~xidel-~ as well as other effects produced by the oxidant in cultured mammalian cells, such as cytotoxicity,'J chromosomal aberrations: sister chromatid exchange~,~J~~ and the formation of r n i c r o n u ~ l e i . ~ ~ ~ ~ ~ The mechanism(s) involved in the enhancing effect of L-histidine on the deleterious effects of hydrogen peroxide is (are) still controversial, although various hypotheses have been made.- Summarized here are some of our recent results in studies to investigate the effects of L-histidineI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
