A convenient synthesis of (S)- and (R)-4-vinyl oxazolidin-2-one from the same inexpensive starting material, D-isoascorbic acid, is described. The two compounds were obtained in 44% and 38% yield, respectively, by operationally simple steps. This approach is a suitable alternative to the literature methods and enhances the synthetic utility of these intermediates.
Synthesis of both enantiomers of 4-vinyl oxazolidin-2-one from a single precursor: D-isoascorbic acid
ZAPPIA, GIOVANNI
2000
Abstract
A convenient synthesis of (S)- and (R)-4-vinyl oxazolidin-2-one from the same inexpensive starting material, D-isoascorbic acid, is described. The two compounds were obtained in 44% and 38% yield, respectively, by operationally simple steps. This approach is a suitable alternative to the literature methods and enhances the synthetic utility of these intermediates.File in questo prodotto:
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