An amphiphilic C60-derivative, AFE, characterized by the presence of the chiral fragment of L-acetyl carnitine in its hydrophilic appendage has been synthesized. In binary (THF/H2O) and ternary (THF/MeOH/H2O) solutions, AFE exhibits a strong tendency to self-aggregation, provided that the Hildebrand polarity index, ä, of the solvent is higher than about 15. A stable aqueous solution of aggregated AFE was obtained. Partition experiments between n-octanol and water show that AFE cannot be spontaneously transferred from water into the organic solvent (and vice versa), although it is effectively “salted-out” by common electrolytes. Light scattering and reversed-phase liquid chromatography experiments carried out on the aqueous solution of AFE suggest for the aggregates an average diameter of 120 nm.

study of the aggregation properties of a novel amphiphilic C60 fullerene derivative

ZAPPIA, GIOVANNI
2001-01-01

Abstract

An amphiphilic C60-derivative, AFE, characterized by the presence of the chiral fragment of L-acetyl carnitine in its hydrophilic appendage has been synthesized. In binary (THF/H2O) and ternary (THF/MeOH/H2O) solutions, AFE exhibits a strong tendency to self-aggregation, provided that the Hildebrand polarity index, ä, of the solvent is higher than about 15. A stable aqueous solution of aggregated AFE was obtained. Partition experiments between n-octanol and water show that AFE cannot be spontaneously transferred from water into the organic solvent (and vice versa), although it is effectively “salted-out” by common electrolytes. Light scattering and reversed-phase liquid chromatography experiments carried out on the aqueous solution of AFE suggest for the aggregates an average diameter of 120 nm.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11576/2302666
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