A one-pot Cu(II)-catalyzed aza-Michael addition of trimethylsilyl azide to 1,2-diaza-1,3-dienes and Cu(I)-catalyzed 1,3-dipolar cycloaddition of in situ generated alpha-azidohydrazones with alkynes is reported. This process combining two consecutive steps with recycling of the catalyst (Cu(OAc)2·H2O) represents a useful protocol for the smooth synthesis of novel pyrazolone-triazole derivatives.
Copper(II)/Copper(I)-catalyzed aza-Michael addition/click reaction of in situ generated alpha-azidohydrazones: synthesis of novel pyrazolone-triazole framework
ATTANASI, ORAZIO ANTONIO;FAVI, GIANFRANCO;FILIPPONE, PAOLINO;MANTELLINI, FABIO;MOSCATELLI, GIADA;PERRULLI, FRANCESCA ROMANA
2010
Abstract
A one-pot Cu(II)-catalyzed aza-Michael addition of trimethylsilyl azide to 1,2-diaza-1,3-dienes and Cu(I)-catalyzed 1,3-dipolar cycloaddition of in situ generated alpha-azidohydrazones with alkynes is reported. This process combining two consecutive steps with recycling of the catalyst (Cu(OAc)2·H2O) represents a useful protocol for the smooth synthesis of novel pyrazolone-triazole derivatives.File in questo prodotto:
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