This article describes the operating principles of the direct-electron ionization (EI) interface, which is becoming more popular in many LC-MS applications. Matrix effects and the role of direct-EI as a universal detector for small molecule analysis are also discussed in detail. The advantages and drawbacks of this approach are described and a comparison with atmospheric pressure ionization (API) interfaces is made. The potential of direct-EI is illustrated with a selection of practical applications.

Towards a universal detector for small molecule application: Direct-EI in LC-MS.

PALMA, PIERANGELA;FAMIGLINI, GIORGIO;TRUFELLI, HELGA;CAPPIELLO, ACHILLE
2011-01-01

Abstract

This article describes the operating principles of the direct-electron ionization (EI) interface, which is becoming more popular in many LC-MS applications. Matrix effects and the role of direct-EI as a universal detector for small molecule analysis are also discussed in detail. The advantages and drawbacks of this approach are described and a comparison with atmospheric pressure ionization (API) interfaces is made. The potential of direct-EI is illustrated with a selection of practical applications.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11576/2506782
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