A stereocontrolled synthesis of (2S,3R)-3-hydroxyproline 1, and trans-(2R,3S)--2-hydroxymethyl-3-hydroxypyrrolidine 2 has been achieved in 21% and 38% yield via the homochiral 4,5-disubstituted oxazolidin-2-one 3. The trans relationship in 2 has beenintroduced by a modified Mitsunobu reaction.
A straightforward synthesis of (2S,3R)-3-hydroxyproline and trans-(2R,3S)-2- hydroxymethyl-3-hydroxypyrrolidine
ZAPPIA, GIOVANNI;
1996
Abstract
A stereocontrolled synthesis of (2S,3R)-3-hydroxyproline 1, and trans-(2R,3S)--2-hydroxymethyl-3-hydroxypyrrolidine 2 has been achieved in 21% and 38% yield via the homochiral 4,5-disubstituted oxazolidin-2-one 3. The trans relationship in 2 has beenintroduced by a modified Mitsunobu reaction.File in questo prodotto:
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