Myogenesis is a multistep process controlled by a transcriptional cascade in which myogenesis regulatory factors (MRFs) have a crucial role [1]. MRFs are a family of basic helix-loop-helix proteins, composed by Myo-D, Myf-5, Myogenin and MRF-4 [2]. They are not activated at the same time: in fact, Myo-D and Myf-5 induce differentiation at earlier step, while Myogenin and MRF-4 are important for myotube formation and for myogenic lineage maintenance [2,3]. C2C12 are murine myoblasts derived from satellite cells and their behaviour corresponds to that of progenitor lineage. They are a subclone of C2 myoblast which spontaneously differentiates in culture after serum removal [5].

Subcellular localization of Myogenic Regulatory Factors along skeletal muscle development

FALCIERI, ELISABETTA;BURATTINI, SABRINA;BIAGIOTTI, LAURA;FERRI, PAOLA;GUESCINI, MICHELE;BARBIERI, ELENA;STOCCHI, VILBERTO
2008-01-01

Abstract

Myogenesis is a multistep process controlled by a transcriptional cascade in which myogenesis regulatory factors (MRFs) have a crucial role [1]. MRFs are a family of basic helix-loop-helix proteins, composed by Myo-D, Myf-5, Myogenin and MRF-4 [2]. They are not activated at the same time: in fact, Myo-D and Myf-5 induce differentiation at earlier step, while Myogenin and MRF-4 are important for myotube formation and for myogenic lineage maintenance [2,3]. C2C12 are murine myoblasts derived from satellite cells and their behaviour corresponds to that of progenitor lineage. They are a subclone of C2 myoblast which spontaneously differentiates in culture after serum removal [5].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11576/2535644
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact