Myogenesis is a multistep process controlled by a transcriptional cascade in which myogenesis regulatory factors (MRFs) have a crucial role [1]. MRFs are a family of basic helix-loop-helix proteins, composed by Myo-D, Myf-5, Myogenin and MRF-4 [2]. They are not activated at the same time: in fact, Myo-D and Myf-5 induce differentiation at earlier step, while Myogenin and MRF-4 are important for myotube formation and for myogenic lineage maintenance [2,3]. C2C12 are murine myoblasts derived from satellite cells and their behaviour corresponds to that of progenitor lineage. They are a subclone of C2 myoblast which spontaneously differentiates in culture after serum removal [5].

Subcellular localization of Myogenic Regulatory Factors along skeletal muscle development

FALCIERI, ELISABETTA;BURATTINI, SABRINA;BIAGIOTTI, LAURA;FERRI, PAOLA;GUESCINI, MICHELE;BARBIERI, ELENA;STOCCHI, VILBERTO
2008

Abstract

Myogenesis is a multistep process controlled by a transcriptional cascade in which myogenesis regulatory factors (MRFs) have a crucial role [1]. MRFs are a family of basic helix-loop-helix proteins, composed by Myo-D, Myf-5, Myogenin and MRF-4 [2]. They are not activated at the same time: in fact, Myo-D and Myf-5 induce differentiation at earlier step, while Myogenin and MRF-4 are important for myotube formation and for myogenic lineage maintenance [2,3]. C2C12 are murine myoblasts derived from satellite cells and their behaviour corresponds to that of progenitor lineage. They are a subclone of C2 myoblast which spontaneously differentiates in culture after serum removal [5].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11576/2535644
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