Myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal hematopoietic stem cell (HSC) malignancies that are characterized by ineffective bone marrow hematopoiesis, peripheral blood cytopenias and a substantial risk of progression to acute myeloid leukemia.1, 2, 3 There is evidence that alterations of the direct interaction between HSCs and stroma contribute to abnormal HSC growth and maturation.4

Overexpression of CDKN2B (p15INK4B) and altered global DNA methylation status in mesenchymal stem cells of high-risk myelodysplastic syndromes

S. Amatori;FANELLI, MIRCO;
2014-01-01

Abstract

Myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal hematopoietic stem cell (HSC) malignancies that are characterized by ineffective bone marrow hematopoiesis, peripheral blood cytopenias and a substantial risk of progression to acute myeloid leukemia.1, 2, 3 There is evidence that alterations of the direct interaction between HSCs and stroma contribute to abnormal HSC growth and maturation.4
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11576/2608202
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