A simple reaction of some oxindole derivatives with 1,2-diaza-1,3-dienes to produce 2-oxo-spiro[indole-3,4’-pyridines] in good yields is here described. This transformation represents a practical two steps approach to new and biologically interesting 2-oxo-spiro[indole-3,4’-pyridine] scaffolds by means of double Michael addition/cyclization sequence.
Synthesis of novel symmetrical 2-oxo-spiro[indole-3,4’-pyridines] by reaction of oxindoles with 1,2-diaza-1,3-dienes
L. De Crescentini;G. Favi;F. Mantellini
2015
Abstract
A simple reaction of some oxindole derivatives with 1,2-diaza-1,3-dienes to produce 2-oxo-spiro[indole-3,4’-pyridines] in good yields is here described. This transformation represents a practical two steps approach to new and biologically interesting 2-oxo-spiro[indole-3,4’-pyridine] scaffolds by means of double Michael addition/cyclization sequence.File in questo prodotto:
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