A simple one-pot procedure for the preparation of symmetrical bis-hydrazone functionalized barbiturates, and a step-by step sequence for the synthesis of analogous unsymmetrical derivatives were developed. Their treatment in acid conditions furnish the symmetrical- and unsymmetricalspirobarbiturate- pyridines, respectively.
Double Michael addition/aza-cyclization: a valuable sequence for the construction of symmetrical and unsymmetrical spirobarbiturate-pyridines
DE CRESCENTINI, LUCIA;ATTANASI, ORAZIO ANTONIO;CAMPISI, LINDA ANTONELLA;FAVI, GIANFRANCO;MANTELLINI, FABIO
2015
Abstract
A simple one-pot procedure for the preparation of symmetrical bis-hydrazone functionalized barbiturates, and a step-by step sequence for the synthesis of analogous unsymmetrical derivatives were developed. Their treatment in acid conditions furnish the symmetrical- and unsymmetricalspirobarbiturate- pyridines, respectively.File in questo prodotto:
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Manuscript revised (2) Tetr 2015.pdf
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