A novel sulpha-Michael addition/formal [3+3] annulation cascade reaction of 1,4-dithiane-2,5-diol and 1,2-diaza-1,3-dienes by a one-pot base-catalyzed strategy has been developed. This metal-free and odourless method provides a practical and facile approach to 1,4-thiazines obtained in total atom economy and in quantitative yields. The synthesis has been scaled-up to gram scale successfully

Facile Odourless Quantitative Synthesis of 3-Hydroxy-3,4-Dihydro-2H-1,4-Thiazines

MARI, GIACOMO;FAVI, GIANFRANCO;DE CRESCENTINI, LUCIA;SANTEUSANIO, STEFANIA;ATTANASI, ORAZIO ANTONIO;MANTELLINI, FABIO
2016

Abstract

A novel sulpha-Michael addition/formal [3+3] annulation cascade reaction of 1,4-dithiane-2,5-diol and 1,2-diaza-1,3-dienes by a one-pot base-catalyzed strategy has been developed. This metal-free and odourless method provides a practical and facile approach to 1,4-thiazines obtained in total atom economy and in quantitative yields. The synthesis has been scaled-up to gram scale successfully
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11576/2633410
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