A novel sulpha-Michael addition/formal [3+3] annulation cascade reaction of 1,4-dithiane-2,5-diol and 1,2-diaza-1,3-dienes by a one-pot base-catalyzed strategy has been developed. This metal-free and odourless method provides a practical and facile approach to 1,4-thiazines obtained in total atom economy and in quantitative yields. The synthesis has been scaled-up to gram scale successfully
Facile Odourless Quantitative Synthesis of 3-Hydroxy-3,4-Dihydro-2H-1,4-Thiazines
MARI, GIACOMO;FAVI, GIANFRANCO;DE CRESCENTINI, LUCIA;SANTEUSANIO, STEFANIA;ATTANASI, ORAZIO ANTONIO;MANTELLINI, FABIO
2016
Abstract
A novel sulpha-Michael addition/formal [3+3] annulation cascade reaction of 1,4-dithiane-2,5-diol and 1,2-diaza-1,3-dienes by a one-pot base-catalyzed strategy has been developed. This metal-free and odourless method provides a practical and facile approach to 1,4-thiazines obtained in total atom economy and in quantitative yields. The synthesis has been scaled-up to gram scale successfullyFile in questo prodotto:
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