In this paper we show, in silico, the role of miRNAs in the post-transcriptional regulation of the onco suppressor gene PTEN by means of a (stochastic) competitive model including interactions with miRNAs and other concurrent genes. The model also covers protein formation and the mechanism going from the protein back to the miRNAs. The numerical simulations confirm the biologically observed situation that the increase of miRNAs concentration within the cell results in the lower expression of PTEN, thus suggesting severe implications in brain tumorigenesis.
The Role of miRNAs in Downregulation of PTEN for Glioblastoma Multiforme
CARLETTI, MARGHERITA;
2016
Abstract
In this paper we show, in silico, the role of miRNAs in the post-transcriptional regulation of the onco suppressor gene PTEN by means of a (stochastic) competitive model including interactions with miRNAs and other concurrent genes. The model also covers protein formation and the mechanism going from the protein back to the miRNAs. The numerical simulations confirm the biologically observed situation that the increase of miRNAs concentration within the cell results in the lower expression of PTEN, thus suggesting severe implications in brain tumorigenesis.File in questo prodotto:
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