A facile method for the synthesis of unprecedented pyrrolino-tetrahydroberberine derivatives starting from 1,2-diaza-1,3-dienes and dihydroberberines is reported. The synthesis performs a cascade reaction involving a Michael type addition of the enamine moiety of dihydroberberine to an azoene system, followed by nitrogen cyclization on the resulting iminium ion.
Unprecedented Heteroring Annulated Pyrrolino-tetrahydroberberine Analogues
MARI, GIACOMO;DE CRESCENTINI, LUCIA;FAVI, GIANFRANCO;MANTELLINI, FABIO
2017
Abstract
A facile method for the synthesis of unprecedented pyrrolino-tetrahydroberberine derivatives starting from 1,2-diaza-1,3-dienes and dihydroberberines is reported. The synthesis performs a cascade reaction involving a Michael type addition of the enamine moiety of dihydroberberine to an azoene system, followed by nitrogen cyclization on the resulting iminium ion.File in questo prodotto:
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