A new and efficient synthesis of fully substituted 2,5-dihydrothiophenes by a sequential one-pot four component reaction between primary amines, -ketoesters, aryl isothiocyanates and 1,2-diaza-1,3-dienes (DDs) is reported. A careful selection of the starting materials enables the choice up to six different variations in the architecture of the final products. Furthermore, the acidic treatment of the so obtained 2,5-dihydrothiophenes furnishes the corresponding 5-amino thiophene-2,4-dicarboxylates.
Assembly of Fully Substituted 2,5-Dihydrothiophenes via a Novel Sequential Multicomponent Reaction.
G. Mari;L. De Crescentini;F. Mantellini
Conceptualization
;S. Santeusanio;G. Favi
2018
Abstract
A new and efficient synthesis of fully substituted 2,5-dihydrothiophenes by a sequential one-pot four component reaction between primary amines, -ketoesters, aryl isothiocyanates and 1,2-diaza-1,3-dienes (DDs) is reported. A careful selection of the starting materials enables the choice up to six different variations in the architecture of the final products. Furthermore, the acidic treatment of the so obtained 2,5-dihydrothiophenes furnishes the corresponding 5-amino thiophene-2,4-dicarboxylates.File in questo prodotto:
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