A new and efficient synthesis of fully substituted 2,5-dihydrothiophenes by a sequential one-pot four component reaction between primary amines, -ketoesters, aryl isothiocyanates and 1,2-diaza-1,3-dienes (DDs) is reported. A careful selection of the starting materials enables the choice up to six different variations in the architecture of the final products. Furthermore, the acidic treatment of the so obtained 2,5-dihydrothiophenes furnishes the corresponding 5-amino thiophene-2,4-dicarboxylates.

Assembly of Fully Substituted 2,5-Dihydrothiophenes via a Novel Sequential Multicomponent Reaction.

G. Mari;L. De Crescentini;F. Mantellini
Conceptualization
;
S. Santeusanio;G. Favi
2018-01-01

Abstract

A new and efficient synthesis of fully substituted 2,5-dihydrothiophenes by a sequential one-pot four component reaction between primary amines, -ketoesters, aryl isothiocyanates and 1,2-diaza-1,3-dienes (DDs) is reported. A careful selection of the starting materials enables the choice up to six different variations in the architecture of the final products. Furthermore, the acidic treatment of the so obtained 2,5-dihydrothiophenes furnishes the corresponding 5-amino thiophene-2,4-dicarboxylates.
File in questo prodotto:
File Dimensione Formato  
org.chem.front.-rev.pdf

Open Access dal 19/05/2019

Tipologia: Versione referata/accettata
Licenza: Creative commons
Dimensione 1.31 MB
Formato Adobe PDF
1.31 MB Adobe PDF Visualizza/Apri
OCF_tiofene1.Fabio.pdf

non disponibili

Tipologia: Versione editoriale
Licenza: Pubblico con Copyright
Dimensione 1.78 MB
Formato Adobe PDF
1.78 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11576/2660386
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 25
social impact