Two unprecedented approaches to amply functionalized 2-arylamino 5-hydrazono thiophene-3-carboxylates were reported. The first one is a useful metal-free sequential multi-component synthesis of readily available -ketoesters, isothiocyanates and in situ generated 4-unsubstituted diaza-dienes. The second one is the basic treatment of 2,5-dihydrothiophenes previously prepared by means of an analogous sequential multi-component synthesis where 4-substituted diaza-dienes were employed.

1,2-Diaza-1,3-dienes-based Multi-component Reactions in Sequential Protocols to Synthesize Arylamino 5-hydrazono thiophene-3 carboxylates

Giacomo Mari;Lucia De Crescentini;Gianfranco Favi;Stefania Santeusanio;Fabio Mantellini
2018

Abstract

Two unprecedented approaches to amply functionalized 2-arylamino 5-hydrazono thiophene-3-carboxylates were reported. The first one is a useful metal-free sequential multi-component synthesis of readily available -ketoesters, isothiocyanates and in situ generated 4-unsubstituted diaza-dienes. The second one is the basic treatment of 2,5-dihydrothiophenes previously prepared by means of an analogous sequential multi-component synthesis where 4-substituted diaza-dienes were employed.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11576/2661470
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