Two unprecedented approaches to amply functionalized 2-arylamino 5-hydrazono thiophene-3-carboxylates were reported. The first one is a useful metal-free sequential multi-component synthesis of readily available -ketoesters, isothiocyanates and in situ generated 4-unsubstituted diaza-dienes. The second one is the basic treatment of 2,5-dihydrothiophenes previously prepared by means of an analogous sequential multi-component synthesis where 4-substituted diaza-dienes were employed.
1,2-Diaza-1,3-dienes-based Multi-component Reactions in Sequential Protocols to Synthesize Arylamino 5-hydrazono thiophene-3 carboxylates
Giacomo Mari;Lucia De Crescentini;Gianfranco Favi;Stefania Santeusanio;Fabio Mantellini
2018
Abstract
Two unprecedented approaches to amply functionalized 2-arylamino 5-hydrazono thiophene-3-carboxylates were reported. The first one is a useful metal-free sequential multi-component synthesis of readily available -ketoesters, isothiocyanates and in situ generated 4-unsubstituted diaza-dienes. The second one is the basic treatment of 2,5-dihydrothiophenes previously prepared by means of an analogous sequential multi-component synthesis where 4-substituted diaza-dienes were employed.File in questo prodotto:
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