A synthesis method for the production of N-acyl glutathione, comprising an acylation step, during which, in a water solution with a pH ranging from 8 to 10, glutathione is caused to react with an anhydride with formula (RCO)2O with a formation of S,N-diacyl glutathione, and a subsequent S-acyl group selective alcoholysis step, during which the S,N-diacyl glutathione produced in the previous step is dissolved in an alkoxide/alcohol solution (R'O-/R'OH) and, subsequently, the obtained product is treated with a cation-exchange resin. R is H or a straight or branched hydrocarbon group with a number of carbon atoms ranging from C1 to C24 while R' is a straight or branched radical hydrocarbon group with a number of carbon atoms ranging from C1 to C4.

Metodo di sintesi di derivati del glutatione [Method for the synthesis of glutathione derivatives]

Bartoccini Francesca;Fraternale Alessandra;Piersanti Giovanni
2017

Abstract

A synthesis method for the production of N-acyl glutathione, comprising an acylation step, during which, in a water solution with a pH ranging from 8 to 10, glutathione is caused to react with an anhydride with formula (RCO)2O with a formation of S,N-diacyl glutathione, and a subsequent S-acyl group selective alcoholysis step, during which the S,N-diacyl glutathione produced in the previous step is dissolved in an alkoxide/alcohol solution (R'O-/R'OH) and, subsequently, the obtained product is treated with a cation-exchange resin. R is H or a straight or branched hydrocarbon group with a number of carbon atoms ranging from C1 to C24 while R' is a straight or branched radical hydrocarbon group with a number of carbon atoms ranging from C1 to C4.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11576/2670117
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