A wide range of substituted indoles or polycyclic derivatives containing the indole core are easily accessible by acidic treatment of aromatic amines and 1,2-diaza-1,3-dienes. Unlike the related indole-Bischler synthesis, the regioselectivity of the method here reported is unique and predictable, the yields are generally good and also electron withdrawing substituted indoles are smoothly recovered.

Metal and oxidant free construction of substituted- and/or polycyclic-indoles: a useful alternative to Bischler and related syntheses.

Giacomo Mari
Investigation
;
Lucia De Crescentini;Gianfranco Favi;Stefania Santeusanio;Fabio Mantellini
Writing – Review & Editing
2020-01-01

Abstract

A wide range of substituted indoles or polycyclic derivatives containing the indole core are easily accessible by acidic treatment of aromatic amines and 1,2-diaza-1,3-dienes. Unlike the related indole-Bischler synthesis, the regioselectivity of the method here reported is unique and predictable, the yields are generally good and also electron withdrawing substituted indoles are smoothly recovered.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11576/2678262
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