An unprecedented synthesis of polysubstituted indolefused pyridazines (azacarbolines) from α-indolylhydrazones under oxidative conditions using a combination of iodylbenzene (PhIO2) and trifluoroacetic acid (TFA) has been developed. This transformation is conducted without the need for transition metals, harsh conditions, or an inert atmosphere.

Synthesis of Azacarbolines via PhIO2‑Promoted Intramolecular Oxidative Cyclization of α‑Indolylhydrazones

Matteo Corrieri
Investigation
;
Lucia De Crescentini
Membro del Collaboration Group
;
Fabio Mantellini
Membro del Collaboration Group
;
Giacomo Mari
Membro del Collaboration Group
;
Stefania Santeusanio
Membro del Collaboration Group
;
Gianfranco Favi
Writing – Review & Editing
2021

Abstract

An unprecedented synthesis of polysubstituted indolefused pyridazines (azacarbolines) from α-indolylhydrazones under oxidative conditions using a combination of iodylbenzene (PhIO2) and trifluoroacetic acid (TFA) has been developed. This transformation is conducted without the need for transition metals, harsh conditions, or an inert atmosphere.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11576/2692933
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