An unprecedented synthesis of polysubstituted indolefused pyridazines (azacarbolines) from α-indolylhydrazones under oxidative conditions using a combination of iodylbenzene (PhIO2) and trifluoroacetic acid (TFA) has been developed. This transformation is conducted without the need for transition metals, harsh conditions, or an inert atmosphere.
Synthesis of Azacarbolines via PhIO2‑Promoted Intramolecular Oxidative Cyclization of α‑Indolylhydrazones
Matteo CorrieriInvestigation
;Lucia De CrescentiniMembro del Collaboration Group
;Fabio MantelliniMembro del Collaboration Group
;Giacomo MariMembro del Collaboration Group
;Stefania SanteusanioMembro del Collaboration Group
;Gianfranco Favi
Writing – Review & Editing
2021
Abstract
An unprecedented synthesis of polysubstituted indolefused pyridazines (azacarbolines) from α-indolylhydrazones under oxidative conditions using a combination of iodylbenzene (PhIO2) and trifluoroacetic acid (TFA) has been developed. This transformation is conducted without the need for transition metals, harsh conditions, or an inert atmosphere.File in questo prodotto:
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