A novel protocol for the efficient synthesis of 1H-imidazo[5,1-c][1,4]oxazines has been developed. Aza-Michael addition of selected primary amines to 1,2-diaza-1,3-dienes (DDs) combined with isothiocyanates or isocyanates in sequential 3-CR process, affords 2-thiohydantoins and hydantoins with suitably positioned functional groups to be used for chemoselective acid-promoted ring-fused formation.

Tailored Aza-Michael Addition as Key Feature of Novel Approach to 1H-imidazo[5,1-c][1,4]oxazine Scaffolds

Giacomo Mari
;
Lucia De Crescentini;Gianfranco Favi;Fabio Mantellini;Stefania Santeusanio
2022

Abstract

A novel protocol for the efficient synthesis of 1H-imidazo[5,1-c][1,4]oxazines has been developed. Aza-Michael addition of selected primary amines to 1,2-diaza-1,3-dienes (DDs) combined with isothiocyanates or isocyanates in sequential 3-CR process, affords 2-thiohydantoins and hydantoins with suitably positioned functional groups to be used for chemoselective acid-promoted ring-fused formation.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11576/2704270
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