: A polypeptide homologous to IL-1, with antagonistic activity (IL-1ra), has recently been described. Given the pleiotropic activity of interleukin (IL-1) it is important to establish the spectrum of inhibitory activity of IL-1ra on in vivo action of IL-1. We tested the effect of IL-1ra on IL-1 induced lethality in adrenalectomized mice, hypoglycemia, and induction of serum corticosterone and interleukin 6. Administration of IL-1ra (200 micrograms/mouse) protected adrenalectomized mice against the lethal effect of 1 microgram of IL-1. IL-1ra at 20 micrograms/mouse completely blocked induction of IL-6 and markedly inhibited hypoglycemia and increase in serum corticosterone induced by 0.1 micrograms of IL-1. These data indicate that IL-1ra inhibits the action of IL-1 on different target tissues involved in the various actions of IL-1 in vivo.

Inhibition by interleukin 1 receptor antagonist of in vivo activities of interleukin 1 in mice

Ghezzi, P
1991

Abstract

: A polypeptide homologous to IL-1, with antagonistic activity (IL-1ra), has recently been described. Given the pleiotropic activity of interleukin (IL-1) it is important to establish the spectrum of inhibitory activity of IL-1ra on in vivo action of IL-1. We tested the effect of IL-1ra on IL-1 induced lethality in adrenalectomized mice, hypoglycemia, and induction of serum corticosterone and interleukin 6. Administration of IL-1ra (200 micrograms/mouse) protected adrenalectomized mice against the lethal effect of 1 microgram of IL-1. IL-1ra at 20 micrograms/mouse completely blocked induction of IL-6 and markedly inhibited hypoglycemia and increase in serum corticosterone induced by 0.1 micrograms of IL-1. These data indicate that IL-1ra inhibits the action of IL-1 on different target tissues involved in the various actions of IL-1 in vivo.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11576/2713689
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 20
  • ???jsp.display-item.citation.isi??? ND
social impact