The discovery of structurally unique scaffolds entities with increased complexity and balanced physicochemical properties has the potential to allow synthetic chemists to exploit areas of chemical space that were previously inaccessible. Among the different strategies employed for generating N-heterocycles, cyclization and cycloaddition reactions represent a valuable synthetic tool. The purpose of this minireview is to summarize the recent advances (2009-present) from our laboratory on the generation of intriguing five-, six- and seven-membered mono- or poly-heterocyclic architectures (linear, fused and spiro) employing 1,2-diaza-1,3-dienes (DDs) as key synthons.

1,2-Diaza-1,3-Dienes as a Multifaceted Synthons for the Synthesis of Heterocycles: A Fifteen-Years Update

Lucia De Crescentini
Writing – Original Draft Preparation
;
Giacomo Mari
Membro del Collaboration Group
;
Stefania Santeusanio
Membro del Collaboration Group
;
Gianfranco Favi
Writing – Review & Editing
;
Fabio Mantellini
Writing – Review & Editing
2024

Abstract

The discovery of structurally unique scaffolds entities with increased complexity and balanced physicochemical properties has the potential to allow synthetic chemists to exploit areas of chemical space that were previously inaccessible. Among the different strategies employed for generating N-heterocycles, cyclization and cycloaddition reactions represent a valuable synthetic tool. The purpose of this minireview is to summarize the recent advances (2009-present) from our laboratory on the generation of intriguing five-, six- and seven-membered mono- or poly-heterocyclic architectures (linear, fused and spiro) employing 1,2-diaza-1,3-dienes (DDs) as key synthons.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11576/2741631
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