IRIS
BOTTEGONI, GIOVANNI
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 1.345
EU - Europa 630
AS - Asia 114
OC - Oceania 12
SA - Sud America 4
AF - Africa 2
Totale 2.107
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 1.326
IT - Italia 105
FI - Finlandia 103
SE - Svezia 103
DE - Germania 87
IE - Irlanda 71
TR - Turchia 68
UA - Ucraina 63
GB - Regno Unito 62
CA - Canada 18
SG - Singapore 17
AU - Australia 9
ES - Italia 9
BE - Belgio 8
CN - Cina 8
FR - Francia 8
VN - Vietnam 5
IN - India 4
IR - Iran 3
NL - Olanda 3
NZ - Nuova Zelanda 3
CH - Svizzera 2
CL - Cile 2
HK - Hong Kong 2
JP - Giappone 2
RU - Federazione Russa 2
AR - Argentina 1
AT - Austria 1
BR - Brasile 1
BY - Bielorussia 1
DK - Danimarca 1
ID - Indonesia 1
JM - Giamaica 1
KE - Kenya 1
LA - Repubblica Popolare Democratica del Laos 1
PH - Filippine 1
PK - Pakistan 1
PL - Polonia 1
SA - Arabia Saudita 1
TN - Tunisia 1
Totale 2.107
Salva come PNG Salva come JPEG
Città #
Fairfield 259
Chandler 152
Helsinki 102
New York 93
Wilmington 82
San Diego 69
Dublin 66
Princeton 64
Istanbul 61
Seattle 61
Ann Arbor 58
Houston 53
Woodbridge 46
Ashburn 44
Bremen 41
Cambridge 38
Boardman 31
San Francisco 28
Council Bluffs 26
London 16
Toronto 14
Sant'Ilario d'Enza 11
Singapore 11
Urbino 11
Brussels 8
Portland 8
Treia 8
Bologna 7
Monte Porzio 7
Acton 6
Ascoli Piceno 5
Iesi 5
Kilburn 5
Milan 5
Norwalk 5
Sydney 5
Augusta 4
Berlin 4
Dong Ket 4
Islington 4
Leawood 4
Orta Nova 4
Travaco Siccomario 4
Turin 4
Cardito 3
Chicago 3
Chiswick 3
Haikou 3
New Bedfont 3
Tappahannock 3
Beijing 2
Canberra 2
Central 2
Frankfurt am Main 2
Garden City 2
Melbourne 2
Mülheim 2
Nuremberg 2
Prescot 2
Romainville 2
San Mateo 2
Straengnaes 2
Tokyo 2
Wellington 2
West Jordan 2
Zurich 2
Annandale 1
Ardabil 1
Ardee 1
Bad Durrheim 1
Borås 1
Brookline 1
Cassano Magnago 1
Cervia 1
Civitanova Marche 1
Cleveland 1
Falkenstein 1
Florence 1
Fort Worth 1
Fortaleza 1
Genoa 1
Genova 1
Glasgow 1
Hanoi 1
Hounslow 1
Hyderabad 1
Islamabad 1
Jackson 1
Kanpur 1
Kupang 1
Lappeenranta 1
Manchester 1
Manila 1
Minsk 1
Monmouth Junction 1
Munich 1
Naaldwijk 1
Nairobi 1
Novara 1
Oklahoma City 1
Totale 1.627
Salva come PNG Salva come JPEG
Nome #
BiKi Life Sciences: A New Suite for Molecular Dynamics and Related Methods in Drug Discovery 67
A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition 60
BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease 56
Inhibitors of anandamide transport and their therapeutic use 55
Computational approaches to the study of dual-site and peripheral site binding ache inhibitors 53
Multi-target dopamine D3 receptor modulators: Actionable knowledge for drug design from molecular dynamics and machine learning 48
A catalytically silent FAAH-1 variant drives anandamide transport in neurons 48
Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase 45
A comparative study on the application of hierarchical-agglomerative clustering approaches to organize outputs of reiterated docking runs 45
Benzimidazole derivatives as kinase inhibitors 43
A Computational Study of the Binding of Propidium to the Peripheral Anionic Site of Human Acetylcholinesterase 42
Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48 42
AClAP, Autonomous hierarchical agglomerative Cluster Analysis based protocol to partition conformational datasets 40
Aryl and heteroaryl N-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl] carbamates with improved physico-chemical properties as dual modulators of dopamine D3 receptor and fatty acid amide hydrolase 38
Combining Dyad Protonation and Active Site Plasticity in BACE-1 Structure-Based Drug Design 38
Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 38
Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus) 38
An Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors 37
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 37
Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer's Disease 37
Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies 37
Computational Methods in the Discovery and Design of BACE-1 Inhibitors 36
Multitarget Compounds for Bipolar Disorder: From Rational Design to Preliminary Pharmacokinetic Evaluation 34
A new method for ligand docking to flexible receptors by dual alanine scanning and refinement (SCARE) 34
Modeling lipid raft domains containing a mono-unsaturated phosphatidylethanolamine species 34
Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase 33
Pyrazole-Based Acid Ceramidase Inhibitors: Design, Synthesis, and Structure-Activity Relationships 33
Role of Molecular Dynamics and Related Methods in Drug Discovery 31
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration 31
Diaryl Urea: A Privileged Structure in Anticancer Agents 30
Irreversible protein kinase inhibitors 30
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 29
Structure-Based Predictions of Activity Cliffs 29
Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation 29
Application of conformational clustering in protein-ligand docking 28
Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity 28
Systematic Exploitation of Multiple Receptor Conformations for Virtual Ligand Screening 28
Four-Dimensional Docking: A Fast and Accurate Account of Discrete Receptor Flexibility in Ligand Docking 28
Multi-kinase inhibitors 28
Describing the Conformational Landscape of Small Organic Molecules through Gaussian Mixtures in Dihedral Space 27
Discovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure-Activity Relationship (SAR) 27
Cyclin-dependent kinases: bridging their structure and function through computations 27
Consistent Improvement of Cross-Docking Results Using Binding Site Ensembles Generated with Elastic Network Normal Modes 27
Role of phosphorylated Thr160 for the activation of the CDK2/Cyclin A complex 27
Polo-like kinases inhibitors 27
In silico antitarget screening 27
Non-ATP Competitive Protein Kinase Inhibitors 26
The role of fragment-based and computational methods in polypharmacology 26
The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning 26
Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein-Ligand Residence Times 25
Synthesis, Biological Evaluation, and 3D QSAR Study of 2-Methyl-4oxo-3-oxetanylcarbamic Acid Esters as N-Acylethanolamine Acid Amidase (NAAA) Inhibitors 25
Recipes for the Selection of Experimental Protein Conformations for Virtual Screening 25
Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3 beta Inhibitors 25
Mapping cholesterol interaction sites on serotonin transporter through coarse-grained molecular dynamics 25
Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727 25
Curcumin derivatives as beta-secretase (BACE1) inhibitors 24
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol 24
Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease 24
Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments 24
SERAPhiC: A Benchmark for in Silico Fragment-Based Drug Design 23
Dual inhibition of REV-ERB beta and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells 23
Protein-ligand docking 23
Small Molecule Aurora Kinases Inhibitors 22
The multitarget FAAH inhibitor/D3 partial agonist ARN15381 decreases nicotine self-administration in male rats 20
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 18
Dopamine D3 receptor ligands: a patent review (2014-2020) 14
Systematic Investigation of Dual-Target-Directed Ligands 11
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties 10
Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor 7
Totale 2.181
Salva come PNG Salva come JPEG
Categoria #
all - tutte 24.417
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 24.417
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021289 0 0 0 0 0 0 0 0 0 0 284 5
2021/2022816 106 256 1 22 8 27 53 45 49 8 59 182
2022/2023731 152 49 6 54 58 135 0 40 82 87 44 24
2023/2024268 17 12 15 8 12 103 7 9 26 4 5 50
2024/202577 77 0 0 0 0 0 0 0 0 0 0 0
Totale 2.181