IRIS
BOTTEGONI, GIOVANNI
 Distribuzione geografica
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Continente #
NA - Nord America 2.822
AS - Asia 1.742
EU - Europa 1.346
SA - Sud America 674
AF - Africa 45
OC - Oceania 12
Totale 6.641
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Nazione #
US - Stati Uniti d'America 2.721
SG - Singapore 716
BR - Brasile 536
CN - Cina 445
IT - Italia 274
VN - Vietnam 262
RU - Federazione Russa 242
DE - Germania 134
FI - Finlandia 126
SE - Svezia 112
GB - Regno Unito 104
FR - Francia 93
TR - Turchia 79
IE - Irlanda 71
UA - Ucraina 70
AR - Argentina 61
HK - Hong Kong 55
CA - Canada 50
ID - Indonesia 40
BD - Bangladesh 31
EC - Ecuador 29
IN - India 29
MX - Messico 24
ES - Italia 22
NL - Olanda 21
JP - Giappone 20
PL - Polonia 19
ZA - Sudafrica 15
CL - Cile 12
CO - Colombia 12
BE - Belgio 11
AT - Austria 10
AU - Australia 9
LT - Lituania 9
GT - Guatemala 7
PY - Paraguay 7
IQ - Iraq 6
JM - Giamaica 6
KE - Kenya 6
MA - Marocco 6
PK - Pakistan 6
EG - Egitto 5
NP - Nepal 5
UZ - Uzbekistan 5
VE - Venezuela 5
AZ - Azerbaigian 4
IL - Israele 4
PE - Perù 4
SA - Arabia Saudita 4
UY - Uruguay 4
AE - Emirati Arabi Uniti 3
AL - Albania 3
BO - Bolivia 3
CH - Svizzera 3
IR - Iran 3
JO - Giordania 3
LV - Lettonia 3
NZ - Nuova Zelanda 3
PA - Panama 3
SI - Slovenia 3
SN - Senegal 3
BG - Bulgaria 2
BH - Bahrain 2
BY - Bielorussia 2
CI - Costa d'Avorio 2
CR - Costa Rica 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
DZ - Algeria 2
GR - Grecia 2
HN - Honduras 2
KH - Cambogia 2
KZ - Kazakistan 2
PH - Filippine 2
QA - Qatar 2
SM - San Marino 2
TN - Tunisia 2
AO - Angola 1
BA - Bosnia-Erzegovina 1
BN - Brunei Darussalam 1
BW - Botswana 1
CM - Camerun 1
CY - Cipro 1
CZ - Repubblica Ceca 1
DM - Dominica 1
GY - Guiana 1
HU - Ungheria 1
KR - Corea 1
KW - Kuwait 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
MD - Moldavia 1
MK - Macedonia 1
MN - Mongolia 1
MY - Malesia 1
NI - Nicaragua 1
OM - Oman 1
PR - Porto Rico 1
PT - Portogallo 1
SD - Sudan 1
Totale 6.636
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Città #
Fairfield 259
Singapore 250
Ashburn 239
San Jose 192
Dallas 160
Chandler 152
New York 124
The Dalles 119
Boardman 118
Ho Chi Minh City 113
Helsinki 109
Beijing 86
Wilmington 84
Council Bluffs 78
San Diego 70
Dublin 67
Lauterbourg 67
Princeton 64
Seattle 63
Istanbul 61
Houston 59
Ann Arbor 58
Los Angeles 56
Moscow 53
Hong Kong 50
Hanoi 49
Woodbridge 46
Bremen 41
São Paulo 41
Urbino 40
Cambridge 38
San Francisco 33
Santa Clara 33
Chicago 31
London 23
Milan 23
Tokyo 20
Rome 19
Toronto 17
Warsaw 17
Rio de Janeiro 16
Denver 15
Haiphong 15
Montreal 15
Munich 15
Atlanta 14
Jakarta 14
Orem 14
Poplar 13
Frankfurt am Main 12
Guayaquil 12
Bologna 11
Brussels 11
Buenos Aires 11
Sant'Ilario d'Enza 11
Amsterdam 10
Brasília 10
Johannesburg 10
Lappeenranta 10
Biên Hòa 9
Curitiba 9
Nuremberg 9
Shanghai 9
Stockholm 9
Düsseldorf 8
Mexico City 8
Portland 8
Tianjin 8
Treia 8
Xi'an 8
Belo Horizonte 7
Brooklyn 7
Buffalo 7
Chennai 7
Da Nang 7
Monte Porzio 7
Quito 7
Ribeirão Preto 7
Salvador 7
Shenzhen 7
Vienna 7
Acton 6
Hangzhou 6
Lancaster 6
Ottawa 6
Phoenix 6
Thái Bình 6
Turin 6
Turku 6
Ancona 5
Ascoli Piceno 5
Augusta 5
Berlin 5
Bragança Paulista 5
Columbus 5
Duque de Caxias 5
Guarulhos 5
Iesi 5
Kilburn 5
Nairobi 5
Totale 3.734
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Nome #
Inhibitors of anandamide transport and their therapeutic use 131
A comparative study on the application of hierarchical-agglomerative clustering approaches to organize outputs of reiterated docking runs 128
BiKi Life Sciences: A New Suite for Molecular Dynamics and Related Methods in Drug Discovery 128
BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease 128
Multi-target dopamine D3 receptor modulators: Actionable knowledge for drug design from molecular dynamics and machine learning 127
A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition 126
Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment 125
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 122
A catalytically silent FAAH-1 variant drives anandamide transport in neurons 115
Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 111
Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48 110
Role of Molecular Dynamics and Related Methods in Drug Discovery 108
Combining Dyad Protonation and Active Site Plasticity in BACE-1 Structure-Based Drug Design 107
A Computational Study of the Binding of Propidium to the Peripheral Anionic Site of Human Acetylcholinesterase 107
Multitarget Compounds for Bipolar Disorder: From Rational Design to Preliminary Pharmacokinetic Evaluation 105
Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase 105
Aryl and heteroaryl N-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl] carbamates with improved physico-chemical properties as dual modulators of dopamine D3 receptor and fatty acid amide hydrolase 103
Benzimidazole derivatives as kinase inhibitors 103
Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727 103
An Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors 102
Irreversible protein kinase inhibitors 102
Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer's Disease 98
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration 98
Impact of G protein-coupled receptor conformation on signaling bias: Integrating simulations and biophysical experiments 95
Computational approaches to the study of dual-site and peripheral site binding ache inhibitors 95
A new method for ligand docking to flexible receptors by dual alanine scanning and refinement (SCARE) 93
Modeling lipid raft domains containing a mono-unsaturated phosphatidylethanolamine species 93
Four-Dimensional Docking: A Fast and Accurate Account of Discrete Receptor Flexibility in Ligand Docking 93
Consistent Improvement of Cross-Docking Results Using Binding Site Ensembles Generated with Elastic Network Normal Modes 92
Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase 92
Pyrazole-Based Acid Ceramidase Inhibitors: Design, Synthesis, and Structure-Activity Relationships 92
The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning 91
Comparative Study of Allosteric GPCR Binding Sites and Their Ligandability Potential 90
Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus) 90
Describing the Conformational Landscape of Small Organic Molecules through Gaussian Mixtures in Dihedral Space 89
Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease 88
AClAP, Autonomous hierarchical agglomerative Cluster Analysis based protocol to partition conformational datasets 87
Systematic Investigation of Dual-Target-Directed Ligands 86
Role of phosphorylated Thr160 for the activation of the CDK2/Cyclin A complex 85
Increased throughput in methods for simulating protein ligand binding and unbinding 84
Dual inhibition of REV-ERB beta and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells 84
Non-ATP Competitive Protein Kinase Inhibitors 84
Recipes for the Selection of Experimental Protein Conformations for Virtual Screening 83
Structure-Based Predictions of Activity Cliffs 82
Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein-Ligand Residence Times 81
Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3 beta Inhibitors 81
Polo-like kinases inhibitors 81
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 80
Diaryl Urea: A Privileged Structure in Anticancer Agents 79
Discovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure-Activity Relationship (SAR) 78
Curcumin derivatives as beta-secretase (BACE1) inhibitors 77
Multi-kinase inhibitors 77
The role of fragment-based and computational methods in polypharmacology 76
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 76
Mapping cholesterol interaction sites on serotonin transporter through coarse-grained molecular dynamics 76
Dopamine D3 receptor ligands: a patent review (2014-2020) 75
Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity 75
Protein-ligand docking 75
SERAPhiC: A Benchmark for in Silico Fragment-Based Drug Design 73
Computational Methods in the Discovery and Design of BACE-1 Inhibitors 73
Application of conformational clustering in protein-ligand docking 72
Systematic Exploitation of Multiple Receptor Conformations for Virtual Ligand Screening 72
Synthesis, Biological Evaluation, and 3D QSAR Study of 2-Methyl-4oxo-3-oxetanylcarbamic Acid Esters as N-Acylethanolamine Acid Amidase (NAAA) Inhibitors 71
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol 71
Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments 71
Cyclin-dependent kinases: bridging their structure and function through computations 70
Small Molecule Aurora Kinases Inhibitors 68
The multitarget FAAH inhibitor/D3 partial agonist ARN15381 decreases nicotine self-administration in male rats 65
Pyrazolone-based ERO1 inhibitors in ERO1-driven Triple-Negative Breast Cancer and SEPN1-Related Myopathy: Structure-activity relationship and therapeutic potential 65
Application of Deep Learning to Predict the Persistence, Bioaccumulation, and Toxicity of Pharmaceuticals 61
Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor 61
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties 60
Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies 59
Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation 52
In silico antitarget screening 49
Adiabatic-Bias Molecular Dynamics Simulations Reveal the Impact of Mutations on Muscarinic Antagonist Unbinding Kinetics 40
Disulfiram metabolite Cu(DDC)2 enhances radionuclide uptake in vivo revealing insights into tumoural ablation resistance 19
Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies 8
Synthesis and biological evaluation of mixed aryl-alkyl succinates as modulators of autophagy and apoptosis in gastric carcinoma 7
Totale 6.734
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Categoria #
all - tutte 42.573
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 42.573
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20215 0 0 0 0 0 0 0 0 0 0 0 5
2021/2022816 106 256 1 22 8 27 53 45 49 8 59 182
2022/2023731 152 49 6 54 58 135 0 40 82 87 44 24
2023/2024268 17 12 15 8 12 103 7 9 26 4 5 50
2024/20251.114 82 48 238 5 14 111 121 74 117 182 77 45
2025/20263.516 207 256 562 930 232 171 256 141 246 261 175 79
Totale 6.734