IRIS
BOTTEGONI, GIOVANNI
 Distribuzione geografica
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Continente #
NA - Nord America 2.593
AS - Asia 1.666
EU - Europa 1.319
SA - Sud America 674
AF - Africa 45
OC - Oceania 12
Totale 6.309
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Nazione #
US - Stati Uniti d'America 2.510
SG - Singapore 686
BR - Brasile 536
CN - Cina 416
VN - Vietnam 262
IT - Italia 248
RU - Federazione Russa 242
DE - Germania 134
FI - Finlandia 126
SE - Svezia 112
GB - Regno Unito 103
FR - Francia 93
TR - Turchia 79
IE - Irlanda 71
UA - Ucraina 70
AR - Argentina 61
HK - Hong Kong 50
CA - Canada 42
ID - Indonesia 40
EC - Ecuador 29
IN - India 29
MX - Messico 23
ES - Italia 22
NL - Olanda 21
BD - Bangladesh 20
JP - Giappone 20
PL - Polonia 19
ZA - Sudafrica 15
CL - Cile 12
CO - Colombia 12
BE - Belgio 11
AT - Austria 10
AU - Australia 9
LT - Lituania 9
PY - Paraguay 7
IQ - Iraq 6
KE - Kenya 6
MA - Marocco 6
PK - Pakistan 6
EG - Egitto 5
NP - Nepal 5
UZ - Uzbekistan 5
VE - Venezuela 5
AZ - Azerbaigian 4
GT - Guatemala 4
IL - Israele 4
PE - Perù 4
SA - Arabia Saudita 4
UY - Uruguay 4
AE - Emirati Arabi Uniti 3
AL - Albania 3
BO - Bolivia 3
CH - Svizzera 3
IR - Iran 3
JO - Giordania 3
LV - Lettonia 3
NZ - Nuova Zelanda 3
PA - Panama 3
SI - Slovenia 3
SN - Senegal 3
BG - Bulgaria 2
BH - Bahrain 2
BY - Bielorussia 2
CI - Costa d'Avorio 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
DZ - Algeria 2
GR - Grecia 2
JM - Giamaica 2
KH - Cambogia 2
KZ - Kazakistan 2
PH - Filippine 2
QA - Qatar 2
SM - San Marino 2
TN - Tunisia 2
AO - Angola 1
BA - Bosnia-Erzegovina 1
BN - Brunei Darussalam 1
BW - Botswana 1
CM - Camerun 1
CR - Costa Rica 1
CY - Cipro 1
CZ - Repubblica Ceca 1
DM - Dominica 1
GY - Guiana 1
HN - Honduras 1
HU - Ungheria 1
KR - Corea 1
KW - Kuwait 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
MD - Moldavia 1
MK - Macedonia 1
MN - Mongolia 1
NI - Nicaragua 1
OM - Oman 1
PR - Porto Rico 1
PT - Portogallo 1
SD - Sudan 1
SY - Repubblica araba siriana 1
Totale 6.305
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Città #
Fairfield 259
Singapore 241
Ashburn 223
San Jose 185
Chandler 152
Dallas 151
The Dalles 119
New York 117
Ho Chi Minh City 113
Helsinki 109
Boardman 102
Wilmington 84
Beijing 77
San Diego 70
Dublin 67
Lauterbourg 67
Princeton 64
Seattle 62
Istanbul 61
Ann Arbor 58
Houston 57
Moscow 53
Los Angeles 52
Hanoi 49
Council Bluffs 48
Woodbridge 46
Hong Kong 45
Bremen 41
São Paulo 41
Urbino 39
Cambridge 38
San Francisco 32
Chicago 30
Santa Clara 26
London 22
Milan 21
Tokyo 20
Warsaw 17
Rio de Janeiro 16
Rome 16
Toronto 16
Haiphong 15
Munich 15
Denver 14
Jakarta 14
Poplar 13
Frankfurt am Main 12
Guayaquil 12
Orem 12
Brussels 11
Buenos Aires 11
Sant'Ilario d'Enza 11
Amsterdam 10
Atlanta 10
Bologna 10
Brasília 10
Johannesburg 10
Lappeenranta 10
Montreal 10
Biên Hòa 9
Curitiba 9
Nuremberg 9
Stockholm 9
Düsseldorf 8
Portland 8
Shanghai 8
Treia 8
Xi'an 8
Belo Horizonte 7
Brooklyn 7
Chennai 7
Da Nang 7
Mexico City 7
Monte Porzio 7
Quito 7
Ribeirão Preto 7
Salvador 7
Shenzhen 7
Tianjin 7
Vienna 7
Acton 6
Lancaster 6
Ottawa 6
Phoenix 6
Thái Bình 6
Turku 6
Ascoli Piceno 5
Augusta 5
Berlin 5
Bragança Paulista 5
Buffalo 5
Duque de Caxias 5
Guarulhos 5
Hangzhou 5
Iesi 5
Kilburn 5
Nairobi 5
Norwalk 5
Nova Iguaçu 5
Osasco 5
Totale 3.582
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Nome #
Inhibitors of anandamide transport and their therapeutic use 129
A comparative study on the application of hierarchical-agglomerative clustering approaches to organize outputs of reiterated docking runs 126
BiKi Life Sciences: A New Suite for Molecular Dynamics and Related Methods in Drug Discovery 126
A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition 125
Multi-target dopamine D3 receptor modulators: Actionable knowledge for drug design from molecular dynamics and machine learning 124
BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease 123
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 119
A catalytically silent FAAH-1 variant drives anandamide transport in neurons 114
Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment 112
Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 108
Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48 106
A Computational Study of the Binding of Propidium to the Peripheral Anionic Site of Human Acetylcholinesterase 105
Role of Molecular Dynamics and Related Methods in Drug Discovery 105
Combining Dyad Protonation and Active Site Plasticity in BACE-1 Structure-Based Drug Design 104
Multitarget Compounds for Bipolar Disorder: From Rational Design to Preliminary Pharmacokinetic Evaluation 103
Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase 103
Aryl and heteroaryl N-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl] carbamates with improved physico-chemical properties as dual modulators of dopamine D3 receptor and fatty acid amide hydrolase 103
Benzimidazole derivatives as kinase inhibitors 102
An Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors 101
Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer's Disease 98
Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727 98
Irreversible protein kinase inhibitors 95
Computational approaches to the study of dual-site and peripheral site binding ache inhibitors 93
Four-Dimensional Docking: A Fast and Accurate Account of Discrete Receptor Flexibility in Ligand Docking 91
A new method for ligand docking to flexible receptors by dual alanine scanning and refinement (SCARE) 90
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration 89
Consistent Improvement of Cross-Docking Results Using Binding Site Ensembles Generated with Elastic Network Normal Modes 88
Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus) 88
Impact of G protein-coupled receptor conformation on signaling bias: Integrating simulations and biophysical experiments 87
Describing the Conformational Landscape of Small Organic Molecules through Gaussian Mixtures in Dihedral Space 87
Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase 87
Modeling lipid raft domains containing a mono-unsaturated phosphatidylethanolamine species 87
AClAP, Autonomous hierarchical agglomerative Cluster Analysis based protocol to partition conformational datasets 86
Pyrazole-Based Acid Ceramidase Inhibitors: Design, Synthesis, and Structure-Activity Relationships 86
Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease 84
The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning 83
Comparative Study of Allosteric GPCR Binding Sites and Their Ligandability Potential 82
Systematic Investigation of Dual-Target-Directed Ligands 82
Recipes for the Selection of Experimental Protein Conformations for Virtual Screening 80
Non-ATP Competitive Protein Kinase Inhibitors 79
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 78
Role of phosphorylated Thr160 for the activation of the CDK2/Cyclin A complex 78
Dual inhibition of REV-ERB beta and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells 77
Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3 beta Inhibitors 77
Structure-Based Predictions of Activity Cliffs 76
Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein-Ligand Residence Times 75
Protein-ligand docking 75
Diaryl Urea: A Privileged Structure in Anticancer Agents 75
Polo-like kinases inhibitors 75
Curcumin derivatives as beta-secretase (BACE1) inhibitors 74
Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity 74
Discovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure-Activity Relationship (SAR) 73
The role of fragment-based and computational methods in polypharmacology 73
Multi-kinase inhibitors 73
Application of conformational clustering in protein-ligand docking 72
Computational Methods in the Discovery and Design of BACE-1 Inhibitors 72
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 72
Dopamine D3 receptor ligands: a patent review (2014-2020) 70
Mapping cholesterol interaction sites on serotonin transporter through coarse-grained molecular dynamics 70
Cyclin-dependent kinases: bridging their structure and function through computations 69
SERAPhiC: A Benchmark for in Silico Fragment-Based Drug Design 68
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol 68
Systematic Exploitation of Multiple Receptor Conformations for Virtual Ligand Screening 68
Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments 68
Synthesis, Biological Evaluation, and 3D QSAR Study of 2-Methyl-4oxo-3-oxetanylcarbamic Acid Esters as N-Acylethanolamine Acid Amidase (NAAA) Inhibitors 67
Small Molecule Aurora Kinases Inhibitors 66
Increased throughput in methods for simulating protein ligand binding and unbinding 63
The multitarget FAAH inhibitor/D3 partial agonist ARN15381 decreases nicotine self-administration in male rats 59
Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies 57
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties 55
Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor 55
Application of Deep Learning to Predict the Persistence, Bioaccumulation, and Toxicity of Pharmaceuticals 54
Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation 51
Pyrazolone-based ERO1 inhibitors in ERO1-driven Triple-Negative Breast Cancer and SEPN1-Related Myopathy: Structure-activity relationship and therapeutic potential 49
In silico antitarget screening 48
Adiabatic-Bias Molecular Dynamics Simulations Reveal the Impact of Mutations on Muscarinic Antagonist Unbinding Kinetics 36
Disulfiram metabolite Cu(DDC)2 enhances radionuclide uptake in vivo revealing insights into tumoural ablation resistance 12
Totale 6.400
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Categoria #
all - tutte 40.218
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 40.218
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021289 0 0 0 0 0 0 0 0 0 0 284 5
2021/2022816 106 256 1 22 8 27 53 45 49 8 59 182
2022/2023731 152 49 6 54 58 135 0 40 82 87 44 24
2023/2024268 17 12 15 8 12 103 7 9 26 4 5 50
2024/20251.114 82 48 238 5 14 111 121 74 117 182 77 45
2025/20263.182 207 256 562 930 232 171 256 141 246 181 0 0
Totale 6.400