IRIS
BOTTEGONI, GIOVANNI
 Distribuzione geografica
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Continente #
NA - Nord America 1.468
EU - Europa 719
AS - Asia 325
OC - Oceania 12
SA - Sud America 4
AF - Africa 2
Totale 2.530
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Nazione #
US - Stati Uniti d'America 1.447
SG - Singapore 162
IT - Italia 121
FI - Finlandia 106
SE - Svezia 103
DE - Germania 87
CN - Cina 72
IE - Irlanda 71
TR - Turchia 68
GB - Regno Unito 64
UA - Ucraina 63
RU - Federazione Russa 60
CA - Canada 20
BE - Belgio 11
AU - Australia 9
ES - Italia 9
FR - Francia 8
VN - Vietnam 5
HK - Hong Kong 4
IN - India 4
NL - Olanda 4
IR - Iran 3
LT - Lituania 3
NZ - Nuova Zelanda 3
AT - Austria 2
CH - Svizzera 2
CL - Cile 2
GR - Grecia 2
JP - Giappone 2
AR - Argentina 1
BR - Brasile 1
BY - Bielorussia 1
DK - Danimarca 1
ID - Indonesia 1
JM - Giamaica 1
KE - Kenya 1
LA - Repubblica Popolare Democratica del Laos 1
PH - Filippine 1
PK - Pakistan 1
PL - Polonia 1
SA - Arabia Saudita 1
TN - Tunisia 1
Totale 2.530
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Città #
Fairfield 259
Chandler 152
Singapore 137
Helsinki 102
Boardman 100
New York 94
Wilmington 82
San Diego 69
Dublin 66
Princeton 64
Istanbul 61
Seattle 61
Ann Arbor 58
Houston 53
Moscow 52
Woodbridge 46
Ashburn 44
Bremen 41
Cambridge 38
San Francisco 28
Council Bluffs 26
Urbino 20
London 16
Santa Clara 16
Toronto 14
Brussels 11
Sant'Ilario d'Enza 11
Portland 8
Treia 8
Bologna 7
Monte Porzio 7
Shanghai 7
Acton 6
Beijing 6
Ascoli Piceno 5
Iesi 5
Kilburn 5
Milan 5
Norwalk 5
Shenzhen 5
Sydney 5
Augusta 4
Berlin 4
Dong Ket 4
Guangzhou 4
Islington 4
Lappeenranta 4
Leawood 4
Orta Nova 4
Travaco Siccomario 4
Turin 4
Ancona 3
Cardito 3
Chicago 3
Chiswick 3
Haikou 3
New Bedfont 3
Tappahannock 3
Athens 2
Canberra 2
Central 2
Changsha 2
Frankfurt am Main 2
Garden City 2
Jiaxing 2
Melbourne 2
Mülheim 2
Nuremberg 2
Ottawa 2
Prescot 2
Qingdao 2
Romainville 2
San Mateo 2
Shaoxing 2
Shijiazhuang 2
Straengnaes 2
Tokyo 2
Wellington 2
West Jordan 2
Wuhan 2
Zurich 2
Annandale 1
Ardabil 1
Ardee 1
Bad Durrheim 1
Borås 1
Brookline 1
Budrio 1
Carpi 1
Cassano Magnago 1
Cervia 1
Civitanova Marche 1
Cleveland 1
Falkenstein 1
Florence 1
Fort Worth 1
Fortaleza 1
Genoa 1
Genova 1
Glasgow 1
Totale 1.931
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Nome #
BiKi Life Sciences: A New Suite for Molecular Dynamics and Related Methods in Drug Discovery 74
A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition 70
BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease 63
Inhibitors of anandamide transport and their therapeutic use 62
Computational approaches to the study of dual-site and peripheral site binding ache inhibitors 59
Multi-target dopamine D3 receptor modulators: Actionable knowledge for drug design from molecular dynamics and machine learning 56
A catalytically silent FAAH-1 variant drives anandamide transport in neurons 56
A comparative study on the application of hierarchical-agglomerative clustering approaches to organize outputs of reiterated docking runs 55
Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase 52
Benzimidazole derivatives as kinase inhibitors 51
A Computational Study of the Binding of Propidium to the Peripheral Anionic Site of Human Acetylcholinesterase 50
Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48 49
AClAP, Autonomous hierarchical agglomerative Cluster Analysis based protocol to partition conformational datasets 48
Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 46
Aryl and heteroaryl N-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl] carbamates with improved physico-chemical properties as dual modulators of dopamine D3 receptor and fatty acid amide hydrolase 45
Combining Dyad Protonation and Active Site Plasticity in BACE-1 Structure-Based Drug Design 45
A new method for ligand docking to flexible receptors by dual alanine scanning and refinement (SCARE) 44
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 44
Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus) 44
An Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors 43
Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer's Disease 43
Multitarget Compounds for Bipolar Disorder: From Rational Design to Preliminary Pharmacokinetic Evaluation 42
Computational Methods in the Discovery and Design of BACE-1 Inhibitors 42
Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies 41
Modeling lipid raft domains containing a mono-unsaturated phosphatidylethanolamine species 40
Application of conformational clustering in protein-ligand docking 38
Pyrazole-Based Acid Ceramidase Inhibitors: Design, Synthesis, and Structure-Activity Relationships 38
Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase 37
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration 37
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 35
Role of Molecular Dynamics and Related Methods in Drug Discovery 35
Structure-Based Predictions of Activity Cliffs 35
Diaryl Urea: A Privileged Structure in Anticancer Agents 35
Irreversible protein kinase inhibitors 35
Four-Dimensional Docking: A Fast and Accurate Account of Discrete Receptor Flexibility in Ligand Docking 34
Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation 34
Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity 33
Cyclin-dependent kinases: bridging their structure and function through computations 33
Consistent Improvement of Cross-Docking Results Using Binding Site Ensembles Generated with Elastic Network Normal Modes 33
Describing the Conformational Landscape of Small Organic Molecules through Gaussian Mixtures in Dihedral Space 32
Discovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure-Activity Relationship (SAR) 32
Non-ATP Competitive Protein Kinase Inhibitors 32
Systematic Exploitation of Multiple Receptor Conformations for Virtual Ligand Screening 32
Polo-like kinases inhibitors 32
Multi-kinase inhibitors 32
The role of fragment-based and computational methods in polypharmacology 31
Synthesis, Biological Evaluation, and 3D QSAR Study of 2-Methyl-4oxo-3-oxetanylcarbamic Acid Esters as N-Acylethanolamine Acid Amidase (NAAA) Inhibitors 31
The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning 31
Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727 31
Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein-Ligand Residence Times 30
Recipes for the Selection of Experimental Protein Conformations for Virtual Screening 30
Role of phosphorylated Thr160 for the activation of the CDK2/Cyclin A complex 30
Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3 beta Inhibitors 30
Mapping cholesterol interaction sites on serotonin transporter through coarse-grained molecular dynamics 30
In silico antitarget screening 30
Dual inhibition of REV-ERB beta and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells 29
Curcumin derivatives as beta-secretase (BACE1) inhibitors 29
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol 29
Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease 29
Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments 29
SERAPhiC: A Benchmark for in Silico Fragment-Based Drug Design 28
Protein-ligand docking 28
The multitarget FAAH inhibitor/D3 partial agonist ARN15381 decreases nicotine self-administration in male rats 27
Small Molecule Aurora Kinases Inhibitors 27
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 24
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties 18
Dopamine D3 receptor ligands: a patent review (2014-2020) 18
Systematic Investigation of Dual-Target-Directed Ligands 16
Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor 14
Increased throughput in methods for simulating protein ligand binding and unbinding 5
Comparative Study of Allosteric GPCR Binding Sites and Their Ligandability Potential 4
Totale 2.606
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Categoria #
all - tutte 28.695
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 28.695
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021289 0 0 0 0 0 0 0 0 0 0 284 5
2021/2022816 106 256 1 22 8 27 53 45 49 8 59 182
2022/2023731 152 49 6 54 58 135 0 40 82 87 44 24
2023/2024268 17 12 15 8 12 103 7 9 26 4 5 50
2024/2025502 82 48 238 5 14 111 4 0 0 0 0 0
Totale 2.606