IRIS
BOTTEGONI, GIOVANNI
 Distribuzione geografica
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Continente #
NA - Nord America 2.945
AS - Asia 1.779
EU - Europa 1.372
SA - Sud America 678
Continente sconosciuto - Info sul continente non disponibili 93
AF - Africa 45
OC - Oceania 12
Totale 6.924
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Nazione #
US - Stati Uniti d'America 2.829
SG - Singapore 728
BR - Brasile 538
CN - Cina 455
IT - Italia 294
VN - Vietnam 263
RU - Federazione Russa 242
DE - Germania 134
FI - Finlandia 126
SE - Svezia 112
GB - Regno Unito 104
FR - Francia 94
TR - Turchia 79
IE - Irlanda 71
UA - Ucraina 70
AR - Argentina 61
HK - Hong Kong 58
CA - Canada 55
BD - Bangladesh 40
ID - Indonesia 40
EC - Ecuador 30
IN - India 29
MX - Messico 25
NL - Olanda 25
ES - Italia 23
JP - Giappone 21
PL - Polonia 19
ZA - Sudafrica 15
CO - Colombia 13
CL - Cile 12
BE - Belgio 11
JM - Giamaica 11
AT - Austria 10
AU - Australia 9
LT - Lituania 9
GT - Guatemala 8
PY - Paraguay 7
IQ - Iraq 6
KE - Kenya 6
MA - Marocco 6
NP - Nepal 6
PK - Pakistan 6
EG - Egitto 5
UZ - Uzbekistan 5
VE - Venezuela 5
AZ - Azerbaigian 4
CR - Costa Rica 4
IL - Israele 4
PE - Perù 4
SA - Arabia Saudita 4
UY - Uruguay 4
AE - Emirati Arabi Uniti 3
AL - Albania 3
BO - Bolivia 3
CH - Svizzera 3
IR - Iran 3
JO - Giordania 3
LV - Lettonia 3
NZ - Nuova Zelanda 3
PA - Panama 3
SI - Slovenia 3
SN - Senegal 3
BG - Bulgaria 2
BH - Bahrain 2
BY - Bielorussia 2
CI - Costa d'Avorio 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
DZ - Algeria 2
GR - Grecia 2
HN - Honduras 2
KH - Cambogia 2
KZ - Kazakistan 2
PH - Filippine 2
QA - Qatar 2
SM - San Marino 2
TN - Tunisia 2
AO - Angola 1
BA - Bosnia-Erzegovina 1
BN - Brunei Darussalam 1
BW - Botswana 1
CM - Camerun 1
CY - Cipro 1
CZ - Repubblica Ceca 1
DM - Dominica 1
GY - Guiana 1
HU - Ungheria 1
KR - Corea 1
KW - Kuwait 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
MD - Moldavia 1
MK - Macedonia 1
MN - Mongolia 1
MY - Malesia 1
NI - Nicaragua 1
OM - Oman 1
PR - Porto Rico 1
PT - Portogallo 1
SD - Sudan 1
Totale 6.825
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Città #
Fairfield 259
Singapore 258
Ashburn 244
San Jose 195
Dallas 163
Chandler 152
New York 124
The Dalles 120
Boardman 118
Ho Chi Minh City 114
Helsinki 109
Council Bluffs 91
Beijing 89
Wilmington 84
San Diego 70
Dublin 67
Lauterbourg 67
Princeton 64
Seattle 64
Houston 61
Istanbul 61
Ann Arbor 58
Los Angeles 57
Hong Kong 53
Moscow 53
Santa Clara 52
Hanoi 49
Woodbridge 46
Bremen 41
São Paulo 41
Urbino 40
Cambridge 38
Chicago 36
San Francisco 33
Milan 28
London 23
Rome 20
Tokyo 20
Toronto 18
Warsaw 17
Denver 16
Rio de Janeiro 16
Haiphong 15
Montreal 15
Munich 15
Atlanta 14
Jakarta 14
Orem 14
Poplar 13
Bologna 12
Frankfurt am Main 12
Guayaquil 12
Brussels 11
Buenos Aires 11
Sant'Ilario d'Enza 11
Shanghai 11
Amsterdam 10
Brasília 10
Johannesburg 10
Lappeenranta 10
Biên Hòa 9
Curitiba 9
Mexico City 9
Nuremberg 9
Stockholm 9
Buffalo 8
Düsseldorf 8
Phoenix 8
Portland 8
Tianjin 8
Treia 8
Xi'an 8
Belo Horizonte 7
Brooklyn 7
Chennai 7
Da Nang 7
Kingston 7
Monte Porzio 7
Quito 7
Ribeirão Preto 7
Salvador 7
Shenzhen 7
Vienna 7
Acton 6
Hangzhou 6
Lancaster 6
Osasco 6
Ottawa 6
Thái Bình 6
Turin 6
Turku 6
Ancona 5
Ascoli Piceno 5
Augusta 5
Berlin 5
Bragança Paulista 5
Columbus 5
Dhaka 5
Duque de Caxias 5
Florence 5
Totale 3.820
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Nome #
BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease 135
Inhibitors of anandamide transport and their therapeutic use 133
Multi-target dopamine D3 receptor modulators: Actionable knowledge for drug design from molecular dynamics and machine learning 132
A comparative study on the application of hierarchical-agglomerative clustering approaches to organize outputs of reiterated docking runs 128
BiKi Life Sciences: A New Suite for Molecular Dynamics and Related Methods in Drug Discovery 128
A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition 127
Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment 126
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 123
Impact of G protein-coupled receptor conformation on signaling bias: Integrating simulations and biophysical experiments 116
A catalytically silent FAAH-1 variant drives anandamide transport in neurons 116
Role of Molecular Dynamics and Related Methods in Drug Discovery 113
Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48 112
Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 111
A Computational Study of the Binding of Propidium to the Peripheral Anionic Site of Human Acetylcholinesterase 109
Multitarget Compounds for Bipolar Disorder: From Rational Design to Preliminary Pharmacokinetic Evaluation 108
Combining Dyad Protonation and Active Site Plasticity in BACE-1 Structure-Based Drug Design 108
Irreversible protein kinase inhibitors 107
Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase 106
Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727 105
Aryl and heteroaryl N-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl] carbamates with improved physico-chemical properties as dual modulators of dopamine D3 receptor and fatty acid amide hydrolase 104
Benzimidazole derivatives as kinase inhibitors 104
An Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors 103
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration 103
Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer's Disease 98
Computational approaches to the study of dual-site and peripheral site binding ache inhibitors 97
Comparative Study of Allosteric GPCR Binding Sites and Their Ligandability Potential 96
Consistent Improvement of Cross-Docking Results Using Binding Site Ensembles Generated with Elastic Network Normal Modes 95
Pyrazole-Based Acid Ceramidase Inhibitors: Design, Synthesis, and Structure-Activity Relationships 95
Modeling lipid raft domains containing a mono-unsaturated phosphatidylethanolamine species 95
A new method for ligand docking to flexible receptors by dual alanine scanning and refinement (SCARE) 94
Four-Dimensional Docking: A Fast and Accurate Account of Discrete Receptor Flexibility in Ligand Docking 94
Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase 93
The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning 92
Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus) 92
Dual inhibition of REV-ERB beta and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells 91
Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease 91
Describing the Conformational Landscape of Small Organic Molecules through Gaussian Mixtures in Dihedral Space 90
Non-ATP Competitive Protein Kinase Inhibitors 90
Role of phosphorylated Thr160 for the activation of the CDK2/Cyclin A complex 89
Systematic Investigation of Dual-Target-Directed Ligands 88
AClAP, Autonomous hierarchical agglomerative Cluster Analysis based protocol to partition conformational datasets 87
Increased throughput in methods for simulating protein ligand binding and unbinding 85
Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3 beta Inhibitors 85
Polo-like kinases inhibitors 85
Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein-Ligand Residence Times 84
Recipes for the Selection of Experimental Protein Conformations for Virtual Screening 84
Structure-Based Predictions of Activity Cliffs 83
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 82
Diaryl Urea: A Privileged Structure in Anticancer Agents 81
Discovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure-Activity Relationship (SAR) 80
The role of fragment-based and computational methods in polypharmacology 79
Multi-kinase inhibitors 79
Dopamine D3 receptor ligands: a patent review (2014-2020) 78
Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity 78
Curcumin derivatives as beta-secretase (BACE1) inhibitors 77
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 77
Protein-ligand docking 76
Mapping cholesterol interaction sites on serotonin transporter through coarse-grained molecular dynamics 76
Synthesis, Biological Evaluation, and 3D QSAR Study of 2-Methyl-4oxo-3-oxetanylcarbamic Acid Esters as N-Acylethanolamine Acid Amidase (NAAA) Inhibitors 75
Pyrazolone-based ERO1 inhibitors in ERO1-driven Triple-Negative Breast Cancer and SEPN1-Related Myopathy: Structure-activity relationship and therapeutic potential 74
Application of conformational clustering in protein-ligand docking 74
Computational Methods in the Discovery and Design of BACE-1 Inhibitors 74
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol 74
SERAPhiC: A Benchmark for in Silico Fragment-Based Drug Design 73
Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments 73
Systematic Exploitation of Multiple Receptor Conformations for Virtual Ligand Screening 72
Cyclin-dependent kinases: bridging their structure and function through computations 71
Small Molecule Aurora Kinases Inhibitors 68
The multitarget FAAH inhibitor/D3 partial agonist ARN15381 decreases nicotine self-administration in male rats 66
Application of Deep Learning to Predict the Persistence, Bioaccumulation, and Toxicity of Pharmaceuticals 64
Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor 61
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties 60
Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies 59
Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation 52
In silico antitarget screening 50
Adiabatic-Bias Molecular Dynamics Simulations Reveal the Impact of Mutations on Muscarinic Antagonist Unbinding Kinetics 42
Disulfiram metabolite Cu(DDC)2 enhances radionuclide uptake in vivo revealing insights into tumoural ablation resistance 23
Synthesis and biological evaluation of mixed aryl-alkyl succinates as modulators of autophagy and apoptosis in gastric carcinoma 14
Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies 12
Totale 6.924
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Categoria #
all - tutte 44.079
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 44.079
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022710 0 256 1 22 8 27 53 45 49 8 59 182
2022/2023731 152 49 6 54 58 135 0 40 82 87 44 24
2023/2024268 17 12 15 8 12 103 7 9 26 4 5 50
2024/20251.114 82 48 238 5 14 111 121 74 117 182 77 45
2025/20263.528 207 256 562 930 232 171 256 141 246 261 175 91
2026/2027178 103 75 0 0 0 0 0 0 0 0 0 0
Totale 6.924