IRIS
BOTTEGONI, GIOVANNI
 Distribuzione geografica
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Continente #
NA - Nord America 2.244
AS - Asia 1.417
EU - Europa 1.107
SA - Sud America 666
AF - Africa 41
OC - Oceania 12
Totale 5.487
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Nazione #
US - Stati Uniti d'America 2.166
SG - Singapore 587
BR - Brasile 534
CN - Cina 323
VN - Vietnam 260
IT - Italia 222
RU - Federazione Russa 148
DE - Germania 126
FI - Finlandia 117
SE - Svezia 111
GB - Regno Unito 102
TR - Turchia 78
IE - Irlanda 71
UA - Ucraina 71
AR - Argentina 59
CA - Canada 40
ID - Indonesia 38
EC - Ecuador 28
FR - Francia 27
IN - India 25
ES - Italia 21
HK - Hong Kong 21
MX - Messico 21
PL - Polonia 18
JP - Giappone 17
BD - Bangladesh 16
NL - Olanda 16
ZA - Sudafrica 16
CO - Colombia 12
BE - Belgio 11
CL - Cile 11
AT - Austria 10
AU - Australia 9
LT - Lituania 9
KE - Kenya 6
PY - Paraguay 6
IQ - Iraq 5
MA - Marocco 5
VE - Venezuela 5
AZ - Azerbaigian 4
EG - Egitto 4
GT - Guatemala 4
PE - Perù 4
PK - Pakistan 4
UY - Uruguay 4
AE - Emirati Arabi Uniti 3
AL - Albania 3
BO - Bolivia 3
CH - Svizzera 3
IL - Israele 3
IR - Iran 3
JO - Giordania 3
LV - Lettonia 3
NZ - Nuova Zelanda 3
SA - Arabia Saudita 3
SI - Slovenia 3
UZ - Uzbekistan 3
BG - Bulgaria 2
BH - Bahrain 2
BY - Bielorussia 2
DO - Repubblica Dominicana 2
GR - Grecia 2
JM - Giamaica 2
KH - Cambogia 2
KW - Kuwait 2
KZ - Kazakistan 2
NP - Nepal 2
PA - Panama 2
QA - Qatar 2
SM - San Marino 2
SN - Senegal 2
TN - Tunisia 2
AO - Angola 1
BA - Bosnia-Erzegovina 1
BN - Brunei Darussalam 1
BW - Botswana 1
CI - Costa d'Avorio 1
CM - Camerun 1
CR - Costa Rica 1
CY - Cipro 1
CZ - Repubblica Ceca 1
DK - Danimarca 1
DM - Dominica 1
DZ - Algeria 1
HN - Honduras 1
HU - Ungheria 1
KR - Corea 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
MD - Moldavia 1
MK - Macedonia 1
MN - Mongolia 1
NI - Nicaragua 1
OM - Oman 1
PH - Filippine 1
PR - Porto Rico 1
PT - Portogallo 1
SD - Sudan 1
SY - Repubblica araba siriana 1
TT - Trinidad e Tobago 1
Totale 5.486
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Città #
Fairfield 259
Ashburn 193
Singapore 170
Chandler 152
Dallas 150
New York 115
Ho Chi Minh City 112
Helsinki 105
Boardman 102
Wilmington 84
San Diego 70
Dublin 66
Princeton 64
Beijing 62
Seattle 62
Istanbul 61
Ann Arbor 58
Houston 56
Los Angeles 52
Moscow 52
Hanoi 49
Woodbridge 46
São Paulo 42
Bremen 41
The Dalles 39
Cambridge 38
Urbino 34
San Francisco 31
Chicago 28
Council Bluffs 28
Santa Clara 25
London 22
Hong Kong 18
Milan 17
Tokyo 17
Warsaw 17
Rome 16
Toronto 16
Haiphong 15
Munich 15
Rio de Janeiro 15
Denver 14
Poplar 13
Jakarta 12
Brussels 11
Buenos Aires 11
Guayaquil 11
Johannesburg 11
Sant'Ilario d'Enza 11
Brasília 10
Atlanta 9
Biên Hòa 9
Bologna 9
Frankfurt am Main 9
Orem 9
Amsterdam 8
Curitiba 8
Düsseldorf 8
Montreal 8
Portland 8
Shanghai 8
Stockholm 8
Treia 8
Xi'an 8
Belo Horizonte 7
Monte Porzio 7
Phoenix 7
Quito 7
Ribeirão Preto 7
Salvador 7
Tianjin 7
Vienna 7
Acton 6
Brooklyn 6
Buffalo 6
Chennai 6
Da Nang 6
Lancaster 6
Nuremberg 6
Ottawa 6
Shenzhen 6
Thái Bình 6
Turku 6
Ascoli Piceno 5
Augusta 5
Berlin 5
Bragança Paulista 5
Duque de Caxias 5
Guarulhos 5
Iesi 5
Kilburn 5
Kyiv 5
Lappeenranta 5
Lauterbourg 5
Mexico City 5
Nairobi 5
Norwalk 5
Nova Iguaçu 5
Osasco 5
Paris 5
Totale 3.042
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Nome #
BiKi Life Sciences: A New Suite for Molecular Dynamics and Related Methods in Drug Discovery 117
Inhibitors of anandamide transport and their therapeutic use 115
A comparative study on the application of hierarchical-agglomerative clustering approaches to organize outputs of reiterated docking runs 114
BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease 112
Multi-target dopamine D3 receptor modulators: Actionable knowledge for drug design from molecular dynamics and machine learning 109
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 106
A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition 106
A Computational Study of the Binding of Propidium to the Peripheral Anionic Site of Human Acetylcholinesterase 99
Aryl and heteroaryl N-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl] carbamates with improved physico-chemical properties as dual modulators of dopamine D3 receptor and fatty acid amide hydrolase 98
Benzimidazole derivatives as kinase inhibitors 98
Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 98
Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase 97
A catalytically silent FAAH-1 variant drives anandamide transport in neurons 96
Combining Dyad Protonation and Active Site Plasticity in BACE-1 Structure-Based Drug Design 93
An Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors 92
Role of Molecular Dynamics and Related Methods in Drug Discovery 90
Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48 90
Multitarget Compounds for Bipolar Disorder: From Rational Design to Preliminary Pharmacokinetic Evaluation 89
Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer's Disease 86
Irreversible protein kinase inhibitors 86
Computational approaches to the study of dual-site and peripheral site binding ache inhibitors 83
Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment 82
Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus) 82
AClAP, Autonomous hierarchical agglomerative Cluster Analysis based protocol to partition conformational datasets 81
Consistent Improvement of Cross-Docking Results Using Binding Site Ensembles Generated with Elastic Network Normal Modes 81
Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727 81
A new method for ligand docking to flexible receptors by dual alanine scanning and refinement (SCARE) 80
Four-Dimensional Docking: A Fast and Accurate Account of Discrete Receptor Flexibility in Ligand Docking 80
Describing the Conformational Landscape of Small Organic Molecules through Gaussian Mixtures in Dihedral Space 78
Pyrazole-Based Acid Ceramidase Inhibitors: Design, Synthesis, and Structure-Activity Relationships 77
Modeling lipid raft domains containing a mono-unsaturated phosphatidylethanolamine species 77
Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase 76
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration 73
Dual inhibition of REV-ERB beta and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells 72
The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning 69
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 69
Application of conformational clustering in protein-ligand docking 68
Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity 68
Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease 68
Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein-Ligand Residence Times 67
Non-ATP Competitive Protein Kinase Inhibitors 67
Structure-Based Predictions of Activity Cliffs 67
Polo-like kinases inhibitors 67
Impact of G protein-coupled receptor conformation on signaling bias: Integrating simulations and biophysical experiments 66
Recipes for the Selection of Experimental Protein Conformations for Virtual Screening 66
Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3 beta Inhibitors 66
Multi-kinase inhibitors 66
The role of fragment-based and computational methods in polypharmacology 65
Role of phosphorylated Thr160 for the activation of the CDK2/Cyclin A complex 65
Discovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure-Activity Relationship (SAR) 64
Curcumin derivatives as beta-secretase (BACE1) inhibitors 64
Mapping cholesterol interaction sites on serotonin transporter through coarse-grained molecular dynamics 64
Diaryl Urea: A Privileged Structure in Anticancer Agents 64
Systematic Investigation of Dual-Target-Directed Ligands 63
Cyclin-dependent kinases: bridging their structure and function through computations 63
Systematic Exploitation of Multiple Receptor Conformations for Virtual Ligand Screening 63
Protein-ligand docking 62
SERAPhiC: A Benchmark for in Silico Fragment-Based Drug Design 61
Computational Methods in the Discovery and Design of BACE-1 Inhibitors 61
Synthesis, Biological Evaluation, and 3D QSAR Study of 2-Methyl-4oxo-3-oxetanylcarbamic Acid Esters as N-Acylethanolamine Acid Amidase (NAAA) Inhibitors 61
Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments 61
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 60
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol 59
Small Molecule Aurora Kinases Inhibitors 59
Comparative Study of Allosteric GPCR Binding Sites and Their Ligandability Potential 56
Dopamine D3 receptor ligands: a patent review (2014-2020) 56
Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies 53
Increased throughput in methods for simulating protein ligand binding and unbinding 50
The multitarget FAAH inhibitor/D3 partial agonist ARN15381 decreases nicotine self-administration in male rats 48
Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation 47
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties 46
In silico antitarget screening 44
Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor 42
Adiabatic-Bias Molecular Dynamics Simulations Reveal the Impact of Mutations on Muscarinic Antagonist Unbinding Kinetics 32
null 31
Application of Deep Learning to Predict the Persistence, Bioaccumulation, and Toxicity of Pharmaceuticals 30
Pyrazolone-based ERO1 inhibitors in ERO1-driven Triple-Negative Breast Cancer and SEPN1-Related Myopathy: Structure-activity relationship and therapeutic potential 14
Totale 5.576
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Categoria #
all - tutte 38.712
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 38.712
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021289 0 0 0 0 0 0 0 0 0 0 284 5
2021/2022816 106 256 1 22 8 27 53 45 49 8 59 182
2022/2023731 152 49 6 54 58 135 0 40 82 87 44 24
2023/2024268 17 12 15 8 12 103 7 9 26 4 5 50
2024/20251.114 82 48 238 5 14 111 121 74 117 182 77 45
2025/20262.358 207 256 562 947 243 143 0 0 0 0 0 0
Totale 5.576