IRIS
BOTTEGONI, GIOVANNI
 Distribuzione geografica
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Continente #
NA - Nord America 2.190
AS - Asia 1.388
EU - Europa 1.087
SA - Sud America 654
AF - Africa 40
OC - Oceania 12
Totale 5.371
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Nazione #
US - Stati Uniti d'America 2.118
SG - Singapore 584
BR - Brasile 523
CN - Cina 319
VN - Vietnam 244
IT - Italia 220
RU - Federazione Russa 148
DE - Germania 126
FI - Finlandia 117
SE - Svezia 109
GB - Regno Unito 98
TR - Turchia 78
IE - Irlanda 71
UA - Ucraina 70
AR - Argentina 58
ID - Indonesia 38
CA - Canada 36
EC - Ecuador 28
FR - Francia 27
IN - India 24
ES - Italia 20
HK - Hong Kong 20
MX - Messico 19
BD - Bangladesh 16
JP - Giappone 16
ZA - Sudafrica 16
NL - Olanda 15
CO - Colombia 12
PL - Polonia 12
BE - Belgio 11
CL - Cile 11
AT - Austria 10
AU - Australia 9
LT - Lituania 8
PY - Paraguay 6
IQ - Iraq 5
KE - Kenya 5
MA - Marocco 5
VE - Venezuela 5
AZ - Azerbaigian 4
EG - Egitto 4
GT - Guatemala 4
PE - Perù 4
UY - Uruguay 4
AE - Emirati Arabi Uniti 3
BO - Bolivia 3
CH - Svizzera 3
IR - Iran 3
JO - Giordania 3
LV - Lettonia 3
NZ - Nuova Zelanda 3
PK - Pakistan 3
SA - Arabia Saudita 3
SI - Slovenia 3
AL - Albania 2
BG - Bulgaria 2
BH - Bahrain 2
DO - Repubblica Dominicana 2
GR - Grecia 2
IL - Israele 2
JM - Giamaica 2
KH - Cambogia 2
KW - Kuwait 2
KZ - Kazakistan 2
NP - Nepal 2
PA - Panama 2
QA - Qatar 2
SM - San Marino 2
SN - Senegal 2
TN - Tunisia 2
UZ - Uzbekistan 2
AO - Angola 1
BA - Bosnia-Erzegovina 1
BN - Brunei Darussalam 1
BW - Botswana 1
BY - Bielorussia 1
CI - Costa d'Avorio 1
CM - Camerun 1
CR - Costa Rica 1
CY - Cipro 1
CZ - Repubblica Ceca 1
DK - Danimarca 1
DM - Dominica 1
DZ - Algeria 1
HN - Honduras 1
HU - Ungheria 1
KR - Corea 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
MD - Moldavia 1
MK - Macedonia 1
MN - Mongolia 1
NI - Nicaragua 1
OM - Oman 1
PH - Filippine 1
PR - Porto Rico 1
PT - Portogallo 1
SD - Sudan 1
SY - Repubblica araba siriana 1
TT - Trinidad e Tobago 1
Totale 5.370
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Città #
Fairfield 259
Ashburn 182
Singapore 169
Chandler 152
Dallas 149
New York 112
Ho Chi Minh City 106
Helsinki 105
Boardman 102
Wilmington 84
San Diego 70
Dublin 66
Princeton 64
Beijing 62
Seattle 62
Istanbul 61
Ann Arbor 58
Houston 55
Moscow 52
Hanoi 49
Los Angeles 49
Woodbridge 46
Bremen 41
Cambridge 38
São Paulo 37
Urbino 34
The Dalles 32
San Francisco 31
Council Bluffs 28
Chicago 27
London 22
Santa Clara 22
Hong Kong 17
Milan 17
Rome 16
Tokyo 16
Munich 15
Rio de Janeiro 15
Toronto 14
Denver 12
Haiphong 12
Jakarta 12
Brussels 11
Buenos Aires 11
Guayaquil 11
Johannesburg 11
Sant'Ilario d'Enza 11
Warsaw 11
Brasília 10
Poplar 10
Atlanta 9
Bologna 9
Frankfurt am Main 9
Biên Hòa 8
Curitiba 8
Düsseldorf 8
Portland 8
Shanghai 8
Treia 8
Xi'an 8
Amsterdam 7
Belo Horizonte 7
Monte Porzio 7
Montreal 7
Orem 7
Quito 7
Salvador 7
Vienna 7
Acton 6
Buffalo 6
Chennai 6
Lancaster 6
Nuremberg 6
Ottawa 6
Phoenix 6
Ribeirão Preto 6
Shenzhen 6
Stockholm 6
Thái Bình 6
Tianjin 6
Turku 6
Ascoli Piceno 5
Augusta 5
Berlin 5
Bragança Paulista 5
Brooklyn 5
Da Nang 5
Duque de Caxias 5
Iesi 5
Kilburn 5
Lappeenranta 5
Lauterbourg 5
Mexico City 5
Norwalk 5
Nova Iguaçu 5
Osasco 5
Paris 5
Piracicaba 5
Recife 5
Sydney 5
Totale 2.970
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Nome #
BiKi Life Sciences: A New Suite for Molecular Dynamics and Related Methods in Drug Discovery 115
A comparative study on the application of hierarchical-agglomerative clustering approaches to organize outputs of reiterated docking runs 112
Inhibitors of anandamide transport and their therapeutic use 112
BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease 109
Multi-target dopamine D3 receptor modulators: Actionable knowledge for drug design from molecular dynamics and machine learning 107
A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition 104
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 103
Benzimidazole derivatives as kinase inhibitors 96
Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 96
A Computational Study of the Binding of Propidium to the Peripheral Anionic Site of Human Acetylcholinesterase 96
Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase 95
Aryl and heteroaryl N-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl] carbamates with improved physico-chemical properties as dual modulators of dopamine D3 receptor and fatty acid amide hydrolase 95
A catalytically silent FAAH-1 variant drives anandamide transport in neurons 95
Combining Dyad Protonation and Active Site Plasticity in BACE-1 Structure-Based Drug Design 91
Role of Molecular Dynamics and Related Methods in Drug Discovery 89
Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48 88
Multitarget Compounds for Bipolar Disorder: From Rational Design to Preliminary Pharmacokinetic Evaluation 87
An Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors 87
Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer's Disease 85
Irreversible protein kinase inhibitors 85
Computational approaches to the study of dual-site and peripheral site binding ache inhibitors 82
Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment 81
AClAP, Autonomous hierarchical agglomerative Cluster Analysis based protocol to partition conformational datasets 80
Consistent Improvement of Cross-Docking Results Using Binding Site Ensembles Generated with Elastic Network Normal Modes 80
Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727 80
A new method for ligand docking to flexible receptors by dual alanine scanning and refinement (SCARE) 79
Four-Dimensional Docking: A Fast and Accurate Account of Discrete Receptor Flexibility in Ligand Docking 78
Describing the Conformational Landscape of Small Organic Molecules through Gaussian Mixtures in Dihedral Space 77
Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus) 77
Pyrazole-Based Acid Ceramidase Inhibitors: Design, Synthesis, and Structure-Activity Relationships 75
Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase 74
Modeling lipid raft domains containing a mono-unsaturated phosphatidylethanolamine species 74
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration 72
Dual inhibition of REV-ERB beta and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells 71
The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning 68
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 68
Application of conformational clustering in protein-ligand docking 67
Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity 67
Structure-Based Predictions of Activity Cliffs 67
Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease 67
Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein-Ligand Residence Times 66
Non-ATP Competitive Protein Kinase Inhibitors 66
Polo-like kinases inhibitors 66
Recipes for the Selection of Experimental Protein Conformations for Virtual Screening 65
Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3 beta Inhibitors 65
Multi-kinase inhibitors 65
Impact of G protein-coupled receptor conformation on signaling bias: Integrating simulations and biophysical experiments 64
The role of fragment-based and computational methods in polypharmacology 64
Role of phosphorylated Thr160 for the activation of the CDK2/Cyclin A complex 64
Discovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure-Activity Relationship (SAR) 63
Curcumin derivatives as beta-secretase (BACE1) inhibitors 63
Cyclin-dependent kinases: bridging their structure and function through computations 63
Mapping cholesterol interaction sites on serotonin transporter through coarse-grained molecular dynamics 63
Diaryl Urea: A Privileged Structure in Anticancer Agents 63
Systematic Exploitation of Multiple Receptor Conformations for Virtual Ligand Screening 62
Protein-ligand docking 61
Synthesis, Biological Evaluation, and 3D QSAR Study of 2-Methyl-4oxo-3-oxetanylcarbamic Acid Esters as N-Acylethanolamine Acid Amidase (NAAA) Inhibitors 61
Systematic Investigation of Dual-Target-Directed Ligands 60
SERAPhiC: A Benchmark for in Silico Fragment-Based Drug Design 60
Computational Methods in the Discovery and Design of BACE-1 Inhibitors 60
Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments 60
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 59
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol 58
Small Molecule Aurora Kinases Inhibitors 58
Dopamine D3 receptor ligands: a patent review (2014-2020) 56
Comparative Study of Allosteric GPCR Binding Sites and Their Ligandability Potential 54
Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies 53
Increased throughput in methods for simulating protein ligand binding and unbinding 48
The multitarget FAAH inhibitor/D3 partial agonist ARN15381 decreases nicotine self-administration in male rats 47
Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation 46
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties 45
In silico antitarget screening 44
Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor 41
null 31
Adiabatic-Bias Molecular Dynamics Simulations Reveal the Impact of Mutations on Muscarinic Antagonist Unbinding Kinetics 28
Application of Deep Learning to Predict the Persistence, Bioaccumulation, and Toxicity of Pharmaceuticals 26
Pyrazolone-based ERO1 inhibitors in ERO1-driven Triple-Negative Breast Cancer and SEPN1-Related Myopathy: Structure-activity relationship and therapeutic potential 11
Totale 5.460
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Categoria #
all - tutte 38.448
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 38.448
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021289 0 0 0 0 0 0 0 0 0 0 284 5
2021/2022816 106 256 1 22 8 27 53 45 49 8 59 182
2022/2023731 152 49 6 54 58 135 0 40 82 87 44 24
2023/2024268 17 12 15 8 12 103 7 9 26 4 5 50
2024/20251.114 82 48 238 5 14 111 121 74 117 182 77 45
2025/20262.242 207 256 562 947 243 27 0 0 0 0 0 0
Totale 5.460