IRIS
BOTTEGONI, GIOVANNI
 Distribuzione geografica
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Continente #
NA - Nord America 3.391
AS - Asia 1.809
EU - Europa 1.489
SA - Sud America 695
Continente sconosciuto - Info sul continente non disponibili 96
AF - Africa 48
OC - Oceania 12
Totale 7.540
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Nazione #
US - Stati Uniti d'America 3.240
SG - Singapore 732
BR - Brasile 542
CN - Cina 461
IT - Italia 384
VN - Vietnam 264
RU - Federazione Russa 242
DE - Germania 136
FI - Finlandia 126
GB - Regno Unito 116
SE - Svezia 112
FR - Francia 98
TR - Turchia 79
IE - Irlanda 72
CA - Canada 71
UA - Ucraina 71
HK - Hong Kong 62
AR - Argentina 61
ID - Indonesia 44
BD - Bangladesh 43
EC - Ecuador 34
IN - India 30
MX - Messico 27
ES - Italia 25
NL - Olanda 25
JP - Giappone 22
CO - Colombia 19
PL - Polonia 19
ZA - Sudafrica 15
JM - Giamaica 14
LT - Lituania 13
CL - Cile 12
BE - Belgio 11
AT - Austria 10
AU - Australia 9
GT - Guatemala 9
CR - Costa Rica 7
KE - Kenya 7
NP - Nepal 7
PY - Paraguay 7
VE - Venezuela 7
IQ - Iraq 6
MA - Marocco 6
PK - Pakistan 6
SA - Arabia Saudita 6
EG - Egitto 5
PE - Perù 5
UZ - Uzbekistan 5
AZ - Azerbaigian 4
IL - Israele 4
UY - Uruguay 4
AE - Emirati Arabi Uniti 3
AL - Albania 3
BH - Bahrain 3
BO - Bolivia 3
CH - Svizzera 3
HN - Honduras 3
IR - Iran 3
JO - Giordania 3
LV - Lettonia 3
NZ - Nuova Zelanda 3
PA - Panama 3
PH - Filippine 3
QA - Qatar 3
SI - Slovenia 3
SN - Senegal 3
TT - Trinidad e Tobago 3
BG - Bulgaria 2
BY - Bielorussia 2
CI - Costa d'Avorio 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
DZ - Algeria 2
GR - Grecia 2
KH - Cambogia 2
KZ - Kazakistan 2
NI - Nicaragua 2
SC - Seychelles 2
SM - San Marino 2
TN - Tunisia 2
AG - Antigua e Barbuda 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BN - Brunei Darussalam 1
BS - Bahamas 1
BW - Botswana 1
BZ - Belize 1
CM - Camerun 1
CY - Cipro 1
CZ - Repubblica Ceca 1
DM - Dominica 1
EE - Estonia 1
GD - Grenada 1
GY - Guiana 1
HU - Ungheria 1
KN - Saint Kitts e Nevis 1
KR - Corea 1
KW - Kuwait 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
Totale 7.430
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Città #
Ashburn 354
Singapore 260
Fairfield 259
San Jose 216
Dallas 164
Chandler 152
The Dalles 133
New York 126
Boardman 118
Council Bluffs 118
Ho Chi Minh City 115
Helsinki 109
Beijing 91
Wilmington 85
San Diego 71
Dublin 67
Lauterbourg 67
Princeton 64
Seattle 64
Los Angeles 63
Houston 62
Santa Clara 62
Istanbul 61
Ann Arbor 58
Urbino 58
Hong Kong 56
Moscow 53
Hanoi 49
Woodbridge 46
Chicago 45
São Paulo 43
Bremen 41
Cambridge 38
San Francisco 34
Milan 32
Rome 32
London 23
Tokyo 21
Toronto 21
Montreal 18
Warsaw 17
Denver 16
Phoenix 16
Rio de Janeiro 16
Atlanta 15
Bologna 15
Haiphong 15
Munich 15
Jakarta 14
Orem 14
Guayaquil 13
Poplar 13
Brasília 12
Frankfurt am Main 12
Brooklyn 11
Brussels 11
Buenos Aires 11
Sant'Ilario d'Enza 11
Shanghai 11
Amsterdam 10
Johannesburg 10
Lappeenranta 10
Naples 10
Turin 10
Biên Hòa 9
Buffalo 9
Curitiba 9
Mexico City 9
Nuremberg 9
Stockholm 9
Düsseldorf 8
Kingston 8
Portland 8
Tianjin 8
Treia 8
Xi'an 8
Belo Horizonte 7
Chennai 7
Da Nang 7
Florence 7
Hangzhou 7
Monte Porzio 7
Quito 7
Ribeirão Preto 7
Salvador 7
Shenzhen 7
Vienna 7
Acton 6
Ancona 6
Columbus 6
Guatemala City 6
Lancaster 6
Nairobi 6
Newark 6
Norwalk 6
Osasco 6
Ottawa 6
Thái Bình 6
Turku 6
Ascoli Piceno 5
Totale 4.113
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Nome #
Multi-target dopamine D3 receptor modulators: Actionable knowledge for drug design from molecular dynamics and machine learning 139
BiKi Life Sciences: A New Suite for Molecular Dynamics and Related Methods in Drug Discovery 139
Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment 138
BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease 138
Inhibitors of anandamide transport and their therapeutic use 138
A comparative study on the application of hierarchical-agglomerative clustering approaches to organize outputs of reiterated docking runs 136
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 135
Impact of G protein-coupled receptor conformation on signaling bias: Integrating simulations and biophysical experiments 132
A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition 130
Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 124
A catalytically silent FAAH-1 variant drives anandamide transport in neurons 123
Role of Molecular Dynamics and Related Methods in Drug Discovery 118
Multitarget Compounds for Bipolar Disorder: From Rational Design to Preliminary Pharmacokinetic Evaluation 116
A Computational Study of the Binding of Propidium to the Peripheral Anionic Site of Human Acetylcholinesterase 116
Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48 116
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration 113
Combining Dyad Protonation and Active Site Plasticity in BACE-1 Structure-Based Drug Design 111
Irreversible protein kinase inhibitors 110
Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase 109
Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727 109
Benzimidazole derivatives as kinase inhibitors 108
Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer's Disease 108
Comparative Study of Allosteric GPCR Binding Sites and Their Ligandability Potential 106
An Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors 106
Aryl and heteroaryl N-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl] carbamates with improved physico-chemical properties as dual modulators of dopamine D3 receptor and fatty acid amide hydrolase 105
Systematic Investigation of Dual-Target-Directed Ligands 104
Computational approaches to the study of dual-site and peripheral site binding ache inhibitors 103
A new method for ligand docking to flexible receptors by dual alanine scanning and refinement (SCARE) 103
Non-ATP Competitive Protein Kinase Inhibitors 102
Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase 100
Modeling lipid raft domains containing a mono-unsaturated phosphatidylethanolamine species 100
Dual inhibition of REV-ERB beta and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells 99
Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein-Ligand Residence Times 99
Four-Dimensional Docking: A Fast and Accurate Account of Discrete Receptor Flexibility in Ligand Docking 98
Increased throughput in methods for simulating protein ligand binding and unbinding 97
Consistent Improvement of Cross-Docking Results Using Binding Site Ensembles Generated with Elastic Network Normal Modes 97
Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus) 97
Pyrazole-Based Acid Ceramidase Inhibitors: Design, Synthesis, and Structure-Activity Relationships 97
Role of phosphorylated Thr160 for the activation of the CDK2/Cyclin A complex 97
The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning 96
Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease 95
Describing the Conformational Landscape of Small Organic Molecules through Gaussian Mixtures in Dihedral Space 92
Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3 beta Inhibitors 92
AClAP, Autonomous hierarchical agglomerative Cluster Analysis based protocol to partition conformational datasets 91
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 88
Pyrazolone-based ERO1 inhibitors in ERO1-driven Triple-Negative Breast Cancer and SEPN1-Related Myopathy: Structure-activity relationship and therapeutic potential 87
Dopamine D3 receptor ligands: a patent review (2014-2020) 87
SERAPhiC: A Benchmark for in Silico Fragment-Based Drug Design 87
Polo-like kinases inhibitors 87
Application of conformational clustering in protein-ligand docking 86
The role of fragment-based and computational methods in polypharmacology 86
Structure-Based Predictions of Activity Cliffs 86
Discovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure-Activity Relationship (SAR) 85
Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity 85
Recipes for the Selection of Experimental Protein Conformations for Virtual Screening 85
Diaryl Urea: A Privileged Structure in Anticancer Agents 85
Computational Methods in the Discovery and Design of BACE-1 Inhibitors 84
Cyclin-dependent kinases: bridging their structure and function through computations 83
Mapping cholesterol interaction sites on serotonin transporter through coarse-grained molecular dynamics 83
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 82
Protein-ligand docking 81
Multi-kinase inhibitors 81
Curcumin derivatives as beta-secretase (BACE1) inhibitors 80
Synthesis, Biological Evaluation, and 3D QSAR Study of 2-Methyl-4oxo-3-oxetanylcarbamic Acid Esters as N-Acylethanolamine Acid Amidase (NAAA) Inhibitors 80
Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments 80
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol 79
Small Molecule Aurora Kinases Inhibitors 79
Systematic Exploitation of Multiple Receptor Conformations for Virtual Ligand Screening 76
The multitarget FAAH inhibitor/D3 partial agonist ARN15381 decreases nicotine self-administration in male rats 75
Application of Deep Learning to Predict the Persistence, Bioaccumulation, and Toxicity of Pharmaceuticals 72
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties 70
Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor 69
Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies 64
Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation 56
In silico antitarget screening 52
Adiabatic-Bias Molecular Dynamics Simulations Reveal the Impact of Mutations on Muscarinic Antagonist Unbinding Kinetics 49
Disulfiram metabolite Cu(DDC)2 enhances radionuclide uptake in vivo revealing insights into tumoural ablation resistance 35
Synthesis and biological evaluation of mixed aryl-alkyl succinates as modulators of autophagy and apoptosis in gastric carcinoma 35
Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies 32
Targeting de novo L-cysteine biosynthesis (DeNoCB) in Pseudomonas aeruginosa for novel antimicrobial strategies 30
Second Generation of 2,2′-Di(indol-3-yl)ethanamines as Antileishmanial Agents: Phenotypic Hit Identification and Pharmacophore Studies 14
Redox Control of S-Sulfocysteine Formation in Adenosine Phosphosulfate Reductase 3
Totale 7.540
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Categoria #
all - tutte 46.877
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 46.877
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022453 0 0 0 22 8 27 53 45 49 8 59 182
2022/2023731 152 49 6 54 58 135 0 40 82 87 44 24
2023/2024268 17 12 15 8 12 103 7 9 26 4 5 50
2024/20251.114 82 48 238 5 14 111 121 74 117 182 77 45
2025/20263.528 207 256 562 930 232 171 256 141 246 261 175 91
2026/2027794 103 109 335 247 0 0 0 0 0 0 0 0
Totale 7.540