IRIS
BOTTEGONI, GIOVANNI
 Distribuzione geografica
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Continente #
NA - Nord America 1.310
EU - Europa 612
AS - Asia 35
OC - Oceania 12
SA - Sud America 4
AF - Africa 2
Totale 1.975
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Nazione #
US - Stati Uniti d'America 1.291
SE - Svezia 103
FI - Finlandia 101
IT - Italia 95
DE - Germania 84
IE - Irlanda 71
UA - Ucraina 63
GB - Regno Unito 62
CA - Canada 18
AU - Australia 9
ES - Italia 9
BE - Belgio 8
CN - Cina 8
FR - Francia 8
TR - Turchia 5
VN - Vietnam 5
IN - India 4
IR - Iran 3
NL - Olanda 3
NZ - Nuova Zelanda 3
CH - Svizzera 2
CL - Cile 2
HK - Hong Kong 2
JP - Giappone 2
SG - Singapore 2
AR - Argentina 1
BR - Brasile 1
BY - Bielorussia 1
DK - Danimarca 1
JM - Giamaica 1
KE - Kenya 1
LA - Repubblica Popolare Democratica del Laos 1
PH - Filippine 1
PK - Pakistan 1
PL - Polonia 1
SA - Arabia Saudita 1
TN - Tunisia 1
Totale 1.975
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Città #
Fairfield 259
Chandler 152
Helsinki 101
New York 93
Wilmington 82
San Diego 69
Dublin 66
Princeton 64
Seattle 61
Ann Arbor 58
Houston 53
Woodbridge 46
Ashburn 44
Bremen 41
Cambridge 38
San Francisco 28
Council Bluffs 26
London 16
Toronto 14
Sant'Ilario d'Enza 11
Brussels 8
Portland 8
Treia 8
Bologna 7
Monte Porzio 7
Acton 6
Ascoli Piceno 5
Iesi 5
Kilburn 5
Norwalk 5
Sydney 5
Augusta 4
Berlin 4
Dong Ket 4
Islington 4
Leawood 4
Orta Nova 4
Travaco Siccomario 4
Turin 4
Urbino 4
Cardito 3
Chicago 3
Chiswick 3
Haikou 3
Milan 3
New Bedfont 3
Tappahannock 3
Beijing 2
Canberra 2
Central 2
Frankfurt am Main 2
Garden City 2
Melbourne 2
Mülheim 2
Prescot 2
Romainville 2
San Mateo 2
Straengnaes 2
Tokyo 2
Wellington 2
West Jordan 2
Zurich 2
Ardabil 1
Ardee 1
Bad Durrheim 1
Borås 1
Brookline 1
Cassano Magnago 1
Civitanova Marche 1
Cleveland 1
Falkenstein 1
Florence 1
Fortaleza 1
Genoa 1
Genova 1
Glasgow 1
Hanoi 1
Hounslow 1
Hyderabad 1
Islamabad 1
Kanpur 1
Manchester 1
Manila 1
Minsk 1
Monmouth Junction 1
Naaldwijk 1
Nairobi 1
Novara 1
Nuremberg 1
Oklahoma City 1
Paris 1
Parrano 1
Perugia 1
Pinehaven 1
Redwood City 1
Reston 1
Rockville 1
Rome 1
Saronno 1
Sciacca 1
Totale 1.516
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Nome #
BiKi Life Sciences: A New Suite for Molecular Dynamics and Related Methods in Drug Discovery 65
A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition 58
BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease 52
Inhibitors of anandamide transport and their therapeutic use 52
Computational approaches to the study of dual-site and peripheral site binding ache inhibitors 50
Multi-target dopamine D3 receptor modulators: Actionable knowledge for drug design from molecular dynamics and machine learning 47
A catalytically silent FAAH-1 variant drives anandamide transport in neurons 46
Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase 43
A comparative study on the application of hierarchical-agglomerative clustering approaches to organize outputs of reiterated docking runs 42
Benzimidazole derivatives as kinase inhibitors 40
Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48 40
A Computational Study of the Binding of Propidium to the Peripheral Anionic Site of Human Acetylcholinesterase 39
AClAP, Autonomous hierarchical agglomerative Cluster Analysis based protocol to partition conformational datasets 38
Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies 36
Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 36
Aryl and heteroaryl N-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl] carbamates with improved physico-chemical properties as dual modulators of dopamine D3 receptor and fatty acid amide hydrolase 35
Combining Dyad Protonation and Active Site Plasticity in BACE-1 Structure-Based Drug Design 35
Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus) 35
An Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors 34
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 34
Computational Methods in the Discovery and Design of BACE-1 Inhibitors 34
Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer's Disease 34
Modeling lipid raft domains containing a mono-unsaturated phosphatidylethanolamine species 33
Multitarget Compounds for Bipolar Disorder: From Rational Design to Preliminary Pharmacokinetic Evaluation 32
A new method for ligand docking to flexible receptors by dual alanine scanning and refinement (SCARE) 32
Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase 32
Pyrazole-Based Acid Ceramidase Inhibitors: Design, Synthesis, and Structure-Activity Relationships 32
Role of Molecular Dynamics and Related Methods in Drug Discovery 30
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration 30
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 29
Diaryl Urea: A Privileged Structure in Anticancer Agents 29
Structure-Based Predictions of Activity Cliffs 28
Irreversible protein kinase inhibitors 28
Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity 27
Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation 27
Describing the Conformational Landscape of Small Organic Molecules through Gaussian Mixtures in Dihedral Space 26
Discovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure-Activity Relationship (SAR) 26
Cyclin-dependent kinases: bridging their structure and function through computations 26
Consistent Improvement of Cross-Docking Results Using Binding Site Ensembles Generated with Elastic Network Normal Modes 26
Systematic Exploitation of Multiple Receptor Conformations for Virtual Ligand Screening 26
Four-Dimensional Docking: A Fast and Accurate Account of Discrete Receptor Flexibility in Ligand Docking 26
Polo-like kinases inhibitors 26
In silico antitarget screening 26
The role of fragment-based and computational methods in polypharmacology 25
The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning 25
Role of phosphorylated Thr160 for the activation of the CDK2/Cyclin A complex 25
Multi-kinase inhibitors 25
Application of conformational clustering in protein-ligand docking 24
Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein-Ligand Residence Times 24
Non-ATP Competitive Protein Kinase Inhibitors 24
Synthesis, Biological Evaluation, and 3D QSAR Study of 2-Methyl-4oxo-3-oxetanylcarbamic Acid Esters as N-Acylethanolamine Acid Amidase (NAAA) Inhibitors 24
Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3 beta Inhibitors 24
Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727 24
Recipes for the Selection of Experimental Protein Conformations for Virtual Screening 23
Mapping cholesterol interaction sites on serotonin transporter through coarse-grained molecular dynamics 23
SERAPhiC: A Benchmark for in Silico Fragment-Based Drug Design 22
Dual inhibition of REV-ERB beta and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells 22
Curcumin derivatives as beta-secretase (BACE1) inhibitors 22
Protein-ligand docking 22
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol 22
Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments 22
Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease 21
Small Molecule Aurora Kinases Inhibitors 21
The multitarget FAAH inhibitor/D3 partial agonist ARN15381 decreases nicotine self-administration in male rats 20
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 17
Dopamine D3 receptor ligands: a patent review (2014-2020) 11
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties 8
Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor 6
Totale 2.048
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Categoria #
all - tutte 21.284
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 21.284
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021289 0 0 0 0 0 0 0 0 0 0 284 5
2021/2022816 106 256 1 22 8 27 53 45 49 8 59 182
2022/2023731 152 49 6 54 58 135 0 40 82 87 44 24
2023/2024212 17 12 15 8 12 103 7 9 26 3 0 0
Totale 2.048