The paper describes a new, high hild and efficient synthetic protocol for the preparation of unsymmetrical difunctionalized cyclen and its close derivatives using a modified Ugi reaction (N-split Ugi) is described. The scope of this methodology is further extended by the successful use of various isocyanides, highly functionalized carboxylic acids, and aldehydes.
Direct preparation of unsymmetrical difunctionalized cyclen derivatives by an Ugi multicomponent reaction
PIERSANTI, GIOVANNI;FUSI, VIERI;FORMICA, MAURO;GIORGI, LUCA;ZAPPIA, GIOVANNI
2009
Abstract
The paper describes a new, high hild and efficient synthetic protocol for the preparation of unsymmetrical difunctionalized cyclen and its close derivatives using a modified Ugi reaction (N-split Ugi) is described. The scope of this methodology is further extended by the successful use of various isocyanides, highly functionalized carboxylic acids, and aldehydes.File in questo prodotto:
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