A highly efficient formal inverse electron demand aza Diels–Alder reaction of 1,2-diaza-1,3-dienes (DDs) is accomplished using dehydroalanine esters (DhAs) as electron-rich dienophiles. Both diastereoisomers of unprecedented α,α-disubstituted cyclic tetrahydropyridazine amino acids were obtained in excellent yields, in refluxing acetonitrile without activation.

Synthesis of Tetrahydropyridazine Amino Acid Derivatives by a Formal [4+2| Cycloaddition Reaction of 1,​2-​Diaza-​1,​3-​dienes with Dehydroalanine Esters

ATTANASI, ORAZIO ANTONIO;FAVI, GIANFRANCO;MANTELLINI, FABIO;MOSCATELLI, GIADA;PIERSANTI, GIOVANNI
2013

Abstract

A highly efficient formal inverse electron demand aza Diels–Alder reaction of 1,2-diaza-1,3-dienes (DDs) is accomplished using dehydroalanine esters (DhAs) as electron-rich dienophiles. Both diastereoisomers of unprecedented α,α-disubstituted cyclic tetrahydropyridazine amino acids were obtained in excellent yields, in refluxing acetonitrile without activation.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11576/2580379
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