Psychotic disorder and focal epilepsy in a left-handed patient with chromosome XYY abnormality

Psychotic disorder and focal epilepsy in a left-handed patient with chromosome XYY abnormality: Objective: To discuss the relationship between XYY chromosome abnormality, psychiatric disorders and epilepsy. Method: Single case report. Results: A 34-year-old man with 47, XYY karyotype and normal intelligence was followed-up at a neuropsychiatric clinic for over 30 years. He was first seen at age 3 years with a history of delayed motor and language development and an immunodeficiency syndrome. At age 8 years he developed refractory local epilepsy, and in late adolescence he started to exhibit increasingly prominent obsessive thoughts. paranoid ideation, and aggressive I sexual fantasies and behaviour. Conclusions: When interpreted within the context of previous literature reports. this case suggests a pathophysiological link between XYY chromosome abnormality, characteristic psychiatric symptoms and epilepsy disorder