Plants have always been a source of metabolic compounds useful for human health. Today, the different genetic engineering techniques allow us to modify both whole plants and in vitro cultured tissues and organs for several purposes. These span from the elicitation of bioactive molecules that are already produced by these organisms to de novo biosynthesis of metabolites and recombinant proteins (Burnett et al., 2019). In particular, several studies have focused on the production of compounds with antioxidant, anti-inflammatory and hypoglycemic activity with the long term goals of exploiting their protective role in the prevention of neurodegenerative diseases and cancer, just to cite a few (Zhang et al., 2015). Indeed, plant in vitro systems appear to be reliable and sustainable platforms for the production of such as molecules (Marchev and Georgiev, 2020). Here we show three strategies we are currently pursuing for the production of compounds with antioxidant or immunomodulatory actions in planta.
PRODUCTION OF BIOACTIVE MOLECULES FOR HUMAN HEALTH IN PLANT CELLS: THREE CASE STUDIES
MARICCHIOLO E.;PAOLOCCI F.;FRATERNALE D.;BALLOTTARI M.;POMPA A.
2021
Abstract
Plants have always been a source of metabolic compounds useful for human health. Today, the different genetic engineering techniques allow us to modify both whole plants and in vitro cultured tissues and organs for several purposes. These span from the elicitation of bioactive molecules that are already produced by these organisms to de novo biosynthesis of metabolites and recombinant proteins (Burnett et al., 2019). In particular, several studies have focused on the production of compounds with antioxidant, anti-inflammatory and hypoglycemic activity with the long term goals of exploiting their protective role in the prevention of neurodegenerative diseases and cancer, just to cite a few (Zhang et al., 2015). Indeed, plant in vitro systems appear to be reliable and sustainable platforms for the production of such as molecules (Marchev and Georgiev, 2020). Here we show three strategies we are currently pursuing for the production of compounds with antioxidant or immunomodulatory actions in planta.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
