A single-step practical synthesis of dehydroalanine (Dha) derivatives from commercially available starting materials is reported. The approach comprises a Brønsted acid-catalyzed three-component condensation reaction of pyruvic acid, an alcohol/thiol, and an amide/carbamate. This protocol provided access to several Dha derivatives, including a novel chiral version modified with diverse functional groups, which might be useful for further transformations in the construction of more complex molecules.

Single‐Step Synthesis of Dehydroalanine Derivatives via a Brønsted Acid‐Catalyzed Multicomponent Reaction

Bartoccini, Francesca
;
Mari, Michele
Methodology
;
Retini, Michele
Data Curation
;
Bartolucci, Silvia
Membro del Collaboration Group
;
Piersanti, Giovanni
Writing – Original Draft Preparation
2020

Abstract

A single-step practical synthesis of dehydroalanine (Dha) derivatives from commercially available starting materials is reported. The approach comprises a Brønsted acid-catalyzed three-component condensation reaction of pyruvic acid, an alcohol/thiol, and an amide/carbamate. This protocol provided access to several Dha derivatives, including a novel chiral version modified with diverse functional groups, which might be useful for further transformations in the construction of more complex molecules.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11576/2675752
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