IRIS
SPADONI, GILBERTO
 Distribuzione geografica
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Continente #
NA - Nord America 11.970
EU - Europa 7.823
AS - Asia 2.886
AF - Africa 35
Continente sconosciuto - Info sul continente non disponibili 24
SA - Sud America 23
OC - Oceania 19
AN - Antartide 1
Totale 22.781
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Nazione #
US - Stati Uniti d'America 11.901
GB - Regno Unito 2.907
CN - Cina 1.939
IT - Italia 1.346
UA - Ucraina 1.292
SE - Svezia 754
TR - Turchia 499
FI - Finlandia 469
DE - Germania 382
IE - Irlanda 267
SG - Singapore 235
FR - Francia 102
RU - Federazione Russa 91
IN - India 66
CA - Canada 64
KR - Corea 47
BE - Belgio 46
NL - Olanda 37
VN - Vietnam 26
JP - Giappone 22
ES - Italia 21
EU - Europa 20
PL - Polonia 19
RO - Romania 18
AU - Australia 16
BR - Brasile 13
KE - Kenya 13
CH - Svizzera 10
HK - Hong Kong 10
TG - Togo 9
EG - Egitto 8
IR - Iran 8
DK - Danimarca 7
HR - Croazia 7
AL - Albania 6
PK - Pakistan 6
AT - Austria 5
EE - Estonia 5
A2 - ???statistics.table.value.countryCode.A2??? 4
BG - Bulgaria 4
ID - Indonesia 4
SI - Slovenia 4
AM - Armenia 3
BD - Bangladesh 3
HU - Ungheria 3
IL - Israele 3
IQ - Iraq 3
LA - Repubblica Popolare Democratica del Laos 3
PA - Panama 3
PE - Perù 3
RS - Serbia 3
TW - Taiwan 3
AR - Argentina 2
BO - Bolivia 2
BY - Bielorussia 2
CZ - Repubblica Ceca 2
GR - Grecia 2
GU - Guam 2
IS - Islanda 2
LB - Libano 2
LU - Lussemburgo 2
MA - Marocco 2
PT - Portogallo 2
SA - Arabia Saudita 2
SK - Slovacchia (Repubblica Slovacca) 2
SM - San Marino 2
AE - Emirati Arabi Uniti 1
CL - Cile 1
FK - Isole Falkland (Malvinas) 1
GS - Georgia del Sud e Isole Sandwich Australi 1
IM - Isola di Man 1
JM - Giamaica 1
MD - Moldavia 1
MX - Messico 1
NZ - Nuova Zelanda 1
PY - Paraguay 1
SC - Seychelles 1
SL - Sierra Leone 1
TH - Thailandia 1
ZA - Sudafrica 1
Totale 22.781
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Città #
Southend 2.686
Woodbridge 1.583
Fairfield 1.428
Houston 1.145
Ann Arbor 1.087
Jacksonville 1.012
Chandler 899
Ashburn 688
Cambridge 648
Seattle 592
Wilmington 577
Nanjing 521
Izmir 359
Urbino 287
Boardman 273
Dublin 265
Nanchang 215
Singapore 192
Helsinki 187
San Mateo 166
Princeton 157
Beijing 156
Shenyang 127
New York 109
Hebei 108
Changsha 102
Tianjin 102
Istanbul 88
Düsseldorf 85
Jiaxing 79
Kunming 60
Velikiy Novgorod 59
Des Moines 56
Jinan 54
Bremen 52
San Diego 46
Brussels 45
Seongnam 43
Toronto 40
Santa Clara 38
Mülheim 36
Venice 34
Zhengzhou 34
Hangzhou 33
Shanghai 32
Milan 30
San Francisco 30
Rome 28
Changchun 27
Ningbo 27
Guangzhou 26
London 26
Haikou 25
Wuppertal 23
Los Angeles 21
Bologna 20
Dong Ket 20
Lanzhou 18
Monte Porzio 18
Auburn Hills 17
Parma 17
Dearborn 16
Norwalk 16
Augusta 15
Amsterdam 14
Redwood City 14
Taizhou 13
Tavullia 13
Osimo 12
Ancona 11
Frankfurt am Main 11
Leawood 11
Munich 11
Portland 11
Mcallen 10
Pesaro 10
Shenzhen 10
Ascoli Piceno 9
Borås 9
Lomé 9
Nairobi 9
Naples 9
Rimini 9
Taranto 9
Fuzhou 8
Orange 8
Orciano Di Pesaro 8
Scottsdale 8
São Paulo 8
Tokyo 8
West Jordan 8
Acquasanta Terme 7
Angri 7
Edinburgh 7
Hefei 7
Melbourne 7
Rui'an 7
Acton 6
Berlin 6
Dormagen 6
Totale 17.335
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Nome #
1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID DERIVATIVES AS LIGANDS AT THE GLYCINE-BINDING SITE OF THE N-METHYL-D-ASPARTATE RECEPTOR 328
1-(2-Alkylamidoethyl)-6-methoxyindole Derivatives: A New Class of Potent Indole Melatonin Analogues. 323
Iridium-Catalyzed Direct Synthesis of Tryptamine Derivatives from Indoles: Exploiting N-Protected β-Amino Alcohols as Alkylating Agents 317
1-Aminocyclopropane-1-carboxylic acid derivatives: Synthesis and NMDA receptor complex binding affinity study. 259
Synthesis of 2-substituted tryptophans via a C3- to C2-alkyl migration 247
Synthesis of Tryptamine Derivatives via a Direct, One-Pot Reductive Alkylation of Indoles 245
Derivatizzazione one-pot di indoli per la sintesi di triptofani, pirroloindoline, bis-indoli & co 240
Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties 236
An improved synthesis of cis-4-phenyl-2-propionamidotetralin (4-P-PDOT): a selective MT2 melatonin receptor antagonist. 230
1-Amminocyclopropane-1-Carboxylic Acid Derivatives: A New, General Synthesis and NMDA Receptor Complex Binding Affiniy Study 229
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 227
Tricyclic Alkylamides as Melatonin Receptor Ligands with Antagonist or Inverse Agonist Activity 226
Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012-2014) 226
Organocatalyzed coupling of indoles with dehydroalanine esters: synthesis of bis(indolyl)propanoates and indolacrylates 225
Direct, One-Pot Reductive Alkylation of Anilines with Functionalized Acetals Mediated by Triethylsilane and TFA. Straightforward Route for Unsymmetrically Substituted Ethylenediamine 220
Synthesis and Configuration Determination of All Enantiopure Stereoisomers of the Melatonin Receptor Ligand 4-Phenyl-2-propionamidotetralin using an Expedient Optical Resolution of 4-Phenyl-2-tetralone 220
A Novel One-Pot Approach of Hexahydropyrrolo[2,3-b]indole Nucleus by a cascade addition/cyclization strategy: Synthesis of (±)-Esermethole 218
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis, Binding Affinity for Melatonin Receptor, and Evaluation of the Biological Activity 213
Synthesis and Characterization of New Bivalent Agents as Melatonin- and Histamine H3-Ligands 213
A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties 212
Synthesis and Biological Activity of new melatonin dimeric derivatives. 209
A New Synthesis of 2-Substituted DL-Tryptophan Derivatives 208
Alkyl 2 (Diphenyl-methyleneamino) acrylates in the Synthesis of α-Amino Acids 208
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands 207
Analogues of benzamide as poly(ADP-ribose)transferase inhibitors: a study on structure activity relationships. 203
(E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists. 203
POSITIVE ION-MASS SPECTRA AND COLLISION-INDUCED DISSOCIATION OF SOME 2,3-DIDEHYDRO AMINO ACIDS 200
Design, synthesis and biological activity of hydrogen peroxide responsive arylboronate melatonin hybrids 200
4,5-Dihydroisoxazole and 4,5-dihydro-1,2,4-oxadiazole derivatives from cycloaddition reactions of nitrile oxides to alkyl N-(diphenylmethylene)-α ,β -dehydroamino acids 196
3-(2-Carbamoylvinyl)-4,5-dimethylpyrrole-2-carboxylic acids as ligands at the NMDA glycine-binding site: a study on the 2-carbamoylvinyl chain modification 190
Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines 189
Synthetic Melatonin Receptor Ligands 187
Toward the Definition of Stereochemical Requirements for MT(2)-Selective Antagonists and Partial Agonists by Studying 4-Phenyl-2-propionamidotetralin Derivatives 187
Structural requirements for inhibitors of poly(ADP-ribose) polymerase. 186
The rationale for the development of melatonin receptor ligands 186
Substituted Benzamides as Poly(ADP-Ribose) transferase Inhibitors: Development of new Derivatives by using Computer Graphics Techniques 184
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands. 184
2-Bromomelatonin: Synthesis and characterization of a potent melatonin agonist 183
Synthesis and Structure–Activity Relationships of a Series of Pyrrole Cannabinoid Receptor Agonists 183
Pharmacokinetic and pharmacodynamic evaluation of ramelteon : an insomnia therapy 180
Differentiation between isomeric 1-aminocyclopropane-1-carboxylic acid derivatives by means of chemical ionisation and mass selected collision induced dissociation 179
N (Diphenylmethylene)-α,β−didehydroamino Acid Esters. Thermal and Lewis Acid Induced Dimerizations 179
Reaction of Secondary Acetylenic Bromides with Sodium Nitrite: Synthesis of 3,5-Alkyl(aryl)-4-nitroisoxazoles 179
Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand 177
Conformation by NMR of two tetralin-based receptor ligands 176
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 176
Synthesis, Enantiomeric Resolution and Structure-Activity Relationship Study for a Series of 10,11-Dihydro-5H-dibenzo[a,d]cycloheptene MT2 Receptor Antagonists. 169
Substituent effects on 1,3-dipolar cycloadditions to some 1,1-diphenyl-2-aza-1,3-butadiene derivatives 169
Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit 168
MELATONIN RECEPTOR AGONISTS: SAR AND APPLICATIONS TO THE TREATMENT OF SLEEP-WAKE DISORDERS 167
Brønsted Acid-Catalyzed Bisindolization of α-amido acetals: Synthesis and Anticancer activity of bis(indolyl)ethanamino derivatives 167
Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle 167
New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an in Vivo BRET-Based Discovery Platform 167
5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors, preparation, and therapeutic use.. 166
Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors 166
Diastereo- and enantioselective hydrogenation of a challenging enamide derived from 4-phenyl-2-tetralone: an appealing shortcut towards enantiopure cis-2-aminotetraline derivatives 165
2,3-Dehydroamino acid derivatives as intermediates in the synthesis of heterocyclic compounds. 161
Selective Melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways 160
Reassessing the melatonin pharmacophore: enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue. 160
The Hypnotic and Analgesic Effects of 2-Bromomelatonin 159
Design and synthesis of N-[3,3-diphenyl-propenyl]alkanamides as a novel class of potent MT2-selective Melatonin receptor ligands 158
Bivalent Ligand Approach on N-[2-[(3-methoxyphenyl)methylamino]ethyl]acetamide. Synthesis, Binding Affinity and Intrinsic Acivity for MT(1) and MT(2) melatonin Receptors. 156
Conformationally Restrained Melatonin Analogs: Synthesis, Binding Affinity for the Melatonin Receptor, Evaluation of the Biological Activity, and Molecular Modeling Study 155
N-(DIPHENYLMETHYLENE)-ALPHA,BETA-DIDEHYDROAMINO ACID ESTERS. THERMAL AND LEWIS ACID INDUCED DIMERIZATIONS 154
STRUCTURE-AFFINITY RELATIONSHIPS OF INDOLE-BASED MELATONIN ANALOGS 154
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice 154
Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells 154
2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists 153
Metastable ion studies in the characterization melatonin isomers 152
Recent advances in the development of melatonin MT1 and MT2 receptor agonists 152
Synthesis and conformational study of 3,4-carbocyclic bridged indole melatonin and serotonin analogues 152
Derivati 2-Acilamminoalchilindolici come Antagonisti/Agonisti Parziali della Melatonina 151
N-Acyl-5- and -2,5-substituted tryptamines: synthesis, activity and affinity for human mt1 and MT2 melatonin receptors 150
Description of the constitutive activity of cloned human melatonin receptors hMT1 and hMT2 and discovery of inverse agonists 150
Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study. 150
THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON SELECTED MT1 AND MT2 MELATONIN RECEPTOR LIGANDS: REQUIREMENTS FOR SUBTYPE SELECTIVITY AND INTRINSIC ACTIVITY MODULATION 148
N-(Substituted-anilinoethyl)acylamides: Design, Synthesis and Pharmacological Characterization of a New Class of Melatonin Receptor Ligands 148
Alchilammidi tricicliche: legandi selettivi dei recettori melatoninergici MT1 e MT2 148
Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam 148
Homology models of melatonin receptors: challenges and recent advances 148
Reactions of 3-Carbomethoxy-2-aza-1,3-Butadiene Derivatives with Dienophiles 147
N-acetiltriptamine 2,5-sostituite: sintesi e valutazione dell’attività biologica per i recettori melatoninergici MT1 e MT2 147
Strategies leading to MT2 selective melatonin receptor antagonists 146
Strategies leading to MT2 selective melatonin receptor antagonists 145
Melatonin receptor agonists: new options for insomnia and depression treatment 144
Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models 142
(E)-3-[2-(Carbamoylvinyl)]pyrrol-2-carboxylic acid derivatives: A novel Class of glycine site Antagonists. 141
Progettazione e Sintesi di nuovi ligandi dei recettori MT1 e MT2 della melatonina a struttura difenilalchilammidica. 139
DESIGN AND SYNTHESIS OF MELATONIN RECEPTORS AGONISTS AND ANTAGONISTS 136
Short synthesis of tryptophan and β -carboline derivatives by reaction of indoles with N-(diphenylmethylene)-α ,β -didehydroamino acid esters 136
Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity 134
ANALOGUES OF BENZAMIDE CONTAINING A SULPHUR ATOM AS POLY(ADP-ribose)TRANSFERASE INHIBITORS. 131
Stereospecific Synthesis of N- (Diphenylmethylene)-α,β-didehydroamino Acid Methyl Esters from β-Hydroxy-α-amino Acids 131
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis and Binding Affinity to the Melatonin Receptor 130
Melatonin, non-selective MT1/MT2 and selective MT2 receptor agonists: differential effects on the 24-hr vigilance states 130
SYNTHESIS, BINDING AFFINITY FOR THE MELATONIN RECEPTOR, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF NEW INDOLE-BASED MELATONIN ANALOGUES. 129
Synthesis, Pharmacological Characterization and QSAR Studies on 2-Substituted Indole Melatonin Receptor Ligands 129
Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities 128
Derivati 1-Acilamminoalchilindolici come agonisti della melatonina. 127
Towards the development of mixed MT1-agonist/MT2-antagonist melatonin receptor ligands 127
Totale 17.858
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Categoria #
all - tutte 75.834
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 75.834
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20203.762 0 0 318 1.119 264 423 396 382 251 307 125 177
2020/20212.895 90 194 136 354 164 191 226 244 445 310 363 178
2021/20221.844 170 196 193 250 33 49 74 114 118 106 46 495
2022/20232.759 309 175 73 333 234 605 12 231 449 92 177 69
2023/2024787 58 69 32 99 55 133 47 56 85 63 23 67
2024/2025877 188 149 540 0 0 0 0 0 0 0 0 0
Totale 23.087