IRIS
SPADONI, GILBERTO
 Distribuzione geografica
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Continente #
NA - Nord America 12.021
EU - Europa 8.316
AS - Asia 3.209
AF - Africa 36
Continente sconosciuto - Info sul continente non disponibili 24
SA - Sud America 24
OC - Oceania 19
AN - Antartide 1
Totale 23.650
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Nazione #
US - Stati Uniti d'America 11.948
GB - Regno Unito 2.910
CN - Cina 2.124
IT - Italia 1.405
UA - Ucraina 1.292
SE - Svezia 754
TR - Turchia 500
FI - Finlandia 477
RU - Federazione Russa 472
DE - Germania 398
SG - Singapore 366
IE - Irlanda 267
FR - Francia 102
CA - Canada 67
IN - India 66
NL - Olanda 55
BE - Belgio 49
KR - Corea 47
VN - Vietnam 26
JP - Giappone 22
ES - Italia 21
EU - Europa 20
PL - Polonia 19
RO - Romania 18
AU - Australia 16
BR - Brasile 13
HK - Hong Kong 13
KE - Kenya 13
CH - Svizzera 10
EG - Egitto 9
TG - Togo 9
AT - Austria 8
IR - Iran 8
DK - Danimarca 7
HR - Croazia 7
AL - Albania 6
PK - Pakistan 6
EE - Estonia 5
ID - Indonesia 5
A2 - ???statistics.table.value.countryCode.A2??? 4
BG - Bulgaria 4
IL - Israele 4
PE - Perù 4
SI - Slovenia 4
AM - Armenia 3
BD - Bangladesh 3
CZ - Repubblica Ceca 3
HU - Ungheria 3
IQ - Iraq 3
LA - Repubblica Popolare Democratica del Laos 3
PA - Panama 3
RS - Serbia 3
TW - Taiwan 3
AR - Argentina 2
BO - Bolivia 2
BY - Bielorussia 2
GR - Grecia 2
GU - Guam 2
IS - Islanda 2
LB - Libano 2
LU - Lussemburgo 2
MA - Marocco 2
MX - Messico 2
PT - Portogallo 2
SA - Arabia Saudita 2
SK - Slovacchia (Repubblica Slovacca) 2
SM - San Marino 2
AE - Emirati Arabi Uniti 1
CL - Cile 1
FK - Isole Falkland (Malvinas) 1
GS - Georgia del Sud e Isole Sandwich Australi 1
IM - Isola di Man 1
JM - Giamaica 1
KZ - Kazakistan 1
LT - Lituania 1
MD - Moldavia 1
NZ - Nuova Zelanda 1
PY - Paraguay 1
SC - Seychelles 1
SL - Sierra Leone 1
TH - Thailandia 1
ZA - Sudafrica 1
Totale 23.650
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Città #
Southend 2.686
Woodbridge 1.583
Fairfield 1.428
Houston 1.145
Ann Arbor 1.087
Jacksonville 1.012
Chandler 899
Ashburn 691
Cambridge 648
Seattle 592
Wilmington 577
Nanjing 521
Izmir 359
Urbino 312
Singapore 290
Boardman 273
Dublin 265
Nanchang 215
Helsinki 194
San Mateo 166
Beijing 158
Princeton 157
Shenyang 127
New York 111
Hebei 108
Changsha 103
Tianjin 103
Istanbul 88
Düsseldorf 85
Jiaxing 85
Moscow 65
Kunming 60
Velikiy Novgorod 59
Des Moines 56
Jinan 54
Bremen 52
Brussels 48
San Diego 46
Shanghai 45
Seongnam 43
Toronto 41
Santa Clara 39
Mülheim 36
Zhengzhou 35
Venice 34
Guangzhou 33
Hangzhou 33
Rome 33
Milan 31
San Francisco 30
London 28
Changchun 27
Ningbo 27
Amsterdam 26
Haikou 25
Wuppertal 23
Los Angeles 21
Munich 21
Bologna 20
Dong Ket 20
Lanzhou 18
Monte Porzio 18
Auburn Hills 17
Parma 17
Dearborn 16
Norwalk 16
Augusta 15
Osimo 14
Redwood City 14
Shenzhen 13
Taizhou 13
Tavullia 13
Ancona 11
Frankfurt am Main 11
Leawood 11
Nuremberg 11
Portland 11
Mcallen 10
Pesaro 10
Ascoli Piceno 9
Borås 9
Fuzhou 9
Lomé 9
Nairobi 9
Naples 9
Rimini 9
Taranto 9
Casalecchio di Reno 8
Orange 8
Orciano Di Pesaro 8
Scottsdale 8
São Paulo 8
Tokyo 8
West Jordan 8
Acquasanta Terme 7
Angri 7
Edinburgh 7
Hefei 7
Melbourne 7
Rui'an 7
Totale 17.608
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Nome #
1-(2-Alkylamidoethyl)-6-methoxyindole Derivatives: A New Class of Potent Indole Melatonin Analogues. 345
1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID DERIVATIVES AS LIGANDS AT THE GLYCINE-BINDING SITE OF THE N-METHYL-D-ASPARTATE RECEPTOR 337
Iridium-Catalyzed Direct Synthesis of Tryptamine Derivatives from Indoles: Exploiting N-Protected β-Amino Alcohols as Alkylating Agents 325
1-Aminocyclopropane-1-carboxylic acid derivatives: Synthesis and NMDA receptor complex binding affinity study. 263
Derivatizzazione one-pot di indoli per la sintesi di triptofani, pirroloindoline, bis-indoli & co 257
Synthesis of Tryptamine Derivatives via a Direct, One-Pot Reductive Alkylation of Indoles 252
Synthesis of 2-substituted tryptophans via a C3- to C2-alkyl migration 250
Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties 244
An improved synthesis of cis-4-phenyl-2-propionamidotetralin (4-P-PDOT): a selective MT2 melatonin receptor antagonist. 242
1-Amminocyclopropane-1-Carboxylic Acid Derivatives: A New, General Synthesis and NMDA Receptor Complex Binding Affiniy Study 242
Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012-2014) 233
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 231
Tricyclic Alkylamides as Melatonin Receptor Ligands with Antagonist or Inverse Agonist Activity 229
Organocatalyzed coupling of indoles with dehydroalanine esters: synthesis of bis(indolyl)propanoates and indolacrylates 228
Synthesis and Configuration Determination of All Enantiopure Stereoisomers of the Melatonin Receptor Ligand 4-Phenyl-2-propionamidotetralin using an Expedient Optical Resolution of 4-Phenyl-2-tetralone 228
A Novel One-Pot Approach of Hexahydropyrrolo[2,3-b]indole Nucleus by a cascade addition/cyclization strategy: Synthesis of (±)-Esermethole 224
Direct, One-Pot Reductive Alkylation of Anilines with Functionalized Acetals Mediated by Triethylsilane and TFA. Straightforward Route for Unsymmetrically Substituted Ethylenediamine 223
Synthesis and Characterization of New Bivalent Agents as Melatonin- and Histamine H3-Ligands 222
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis, Binding Affinity for Melatonin Receptor, and Evaluation of the Biological Activity 221
A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties 220
A New Synthesis of 2-Substituted DL-Tryptophan Derivatives 216
Alkyl 2 (Diphenyl-methyleneamino) acrylates in the Synthesis of α-Amino Acids 215
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands 215
Design, synthesis and biological activity of hydrogen peroxide responsive arylboronate melatonin hybrids 212
Analogues of benzamide as poly(ADP-ribose)transferase inhibitors: a study on structure activity relationships. 211
(E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists. 211
Synthesis and Biological Activity of new melatonin dimeric derivatives. 210
POSITIVE ION-MASS SPECTRA AND COLLISION-INDUCED DISSOCIATION OF SOME 2,3-DIDEHYDRO AMINO ACIDS 204
4,5-Dihydroisoxazole and 4,5-dihydro-1,2,4-oxadiazole derivatives from cycloaddition reactions of nitrile oxides to alkyl N-(diphenylmethylene)-α ,β -dehydroamino acids 203
3-(2-Carbamoylvinyl)-4,5-dimethylpyrrole-2-carboxylic acids as ligands at the NMDA glycine-binding site: a study on the 2-carbamoylvinyl chain modification 199
Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines 197
Synthetic Melatonin Receptor Ligands 190
Toward the Definition of Stereochemical Requirements for MT(2)-Selective Antagonists and Partial Agonists by Studying 4-Phenyl-2-propionamidotetralin Derivatives 190
The rationale for the development of melatonin receptor ligands 189
Substituted Benzamides as Poly(ADP-Ribose) transferase Inhibitors: Development of new Derivatives by using Computer Graphics Techniques 189
Structural requirements for inhibitors of poly(ADP-ribose) polymerase. 188
2-Bromomelatonin: Synthesis and characterization of a potent melatonin agonist 187
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands. 187
Synthesis and Structure–Activity Relationships of a Series of Pyrrole Cannabinoid Receptor Agonists 186
N (Diphenylmethylene)-α,β−didehydroamino Acid Esters. Thermal and Lewis Acid Induced Dimerizations 186
Reaction of Secondary Acetylenic Bromides with Sodium Nitrite: Synthesis of 3,5-Alkyl(aryl)-4-nitroisoxazoles 186
Conformation by NMR of two tetralin-based receptor ligands 182
Pharmacokinetic and pharmacodynamic evaluation of ramelteon : an insomnia therapy 182
Differentiation between isomeric 1-aminocyclopropane-1-carboxylic acid derivatives by means of chemical ionisation and mass selected collision induced dissociation 181
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 180
Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand 179
Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit 176
Brønsted Acid-Catalyzed Bisindolization of α-amido acetals: Synthesis and Anticancer activity of bis(indolyl)ethanamino derivatives 175
Synthesis, Enantiomeric Resolution and Structure-Activity Relationship Study for a Series of 10,11-Dihydro-5H-dibenzo[a,d]cycloheptene MT2 Receptor Antagonists. 172
5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors, preparation, and therapeutic use.. 172
Substituent effects on 1,3-dipolar cycloadditions to some 1,1-diphenyl-2-aza-1,3-butadiene derivatives 172
Diastereo- and enantioselective hydrogenation of a challenging enamide derived from 4-phenyl-2-tetralone: an appealing shortcut towards enantiopure cis-2-aminotetraline derivatives 172
New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an in Vivo BRET-Based Discovery Platform 172
MELATONIN RECEPTOR AGONISTS: SAR AND APPLICATIONS TO THE TREATMENT OF SLEEP-WAKE DISORDERS 170
Selective Melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways 170
Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle 170
2,3-Dehydroamino acid derivatives as intermediates in the synthesis of heterocyclic compounds. 167
Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors 167
Design and synthesis of N-[3,3-diphenyl-propenyl]alkanamides as a novel class of potent MT2-selective Melatonin receptor ligands 165
Reassessing the melatonin pharmacophore: enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue. 165
Conformationally Restrained Melatonin Analogs: Synthesis, Binding Affinity for the Melatonin Receptor, Evaluation of the Biological Activity, and Molecular Modeling Study 162
The Hypnotic and Analgesic Effects of 2-Bromomelatonin 161
N-(DIPHENYLMETHYLENE)-ALPHA,BETA-DIDEHYDROAMINO ACID ESTERS. THERMAL AND LEWIS ACID INDUCED DIMERIZATIONS 161
Bivalent Ligand Approach on N-[2-[(3-methoxyphenyl)methylamino]ethyl]acetamide. Synthesis, Binding Affinity and Intrinsic Acivity for MT(1) and MT(2) melatonin Receptors. 161
Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells 161
2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists 161
N-(Substituted-anilinoethyl)acylamides: Design, Synthesis and Pharmacological Characterization of a New Class of Melatonin Receptor Ligands 159
STRUCTURE-AFFINITY RELATIONSHIPS OF INDOLE-BASED MELATONIN ANALOGS 158
N-Acyl-5- and -2,5-substituted tryptamines: synthesis, activity and affinity for human mt1 and MT2 melatonin receptors 157
Metastable ion studies in the characterization melatonin isomers 155
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice 155
Recent advances in the development of melatonin MT1 and MT2 receptor agonists 154
Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam 154
Description of the constitutive activity of cloned human melatonin receptors hMT1 and hMT2 and discovery of inverse agonists 153
Derivati 2-Acilamminoalchilindolici come Antagonisti/Agonisti Parziali della Melatonina 153
Synthesis and conformational study of 3,4-carbocyclic bridged indole melatonin and serotonin analogues 153
N-acetiltriptamine 2,5-sostituite: sintesi e valutazione dell’attività biologica per i recettori melatoninergici MT1 e MT2 152
Alchilammidi tricicliche: legandi selettivi dei recettori melatoninergici MT1 e MT2 152
Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study. 151
THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON SELECTED MT1 AND MT2 MELATONIN RECEPTOR LIGANDS: REQUIREMENTS FOR SUBTYPE SELECTIVITY AND INTRINSIC ACTIVITY MODULATION 150
Reactions of 3-Carbomethoxy-2-aza-1,3-Butadiene Derivatives with Dienophiles 150
Homology models of melatonin receptors: challenges and recent advances 150
Strategies leading to MT2 selective melatonin receptor antagonists 149
(E)-3-[2-(Carbamoylvinyl)]pyrrol-2-carboxylic acid derivatives: A novel Class of glycine site Antagonists. 148
Strategies leading to MT2 selective melatonin receptor antagonists 148
Melatonin receptor agonists: new options for insomnia and depression treatment 148
Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models 145
Progettazione e Sintesi di nuovi ligandi dei recettori MT1 e MT2 della melatonina a struttura difenilalchilammidica. 143
Short synthesis of tryptophan and β -carboline derivatives by reaction of indoles with N-(diphenylmethylene)-α ,β -didehydroamino acid esters 140
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis and Binding Affinity to the Melatonin Receptor 139
ANALOGUES OF BENZAMIDE CONTAINING A SULPHUR ATOM AS POLY(ADP-ribose)TRANSFERASE INHIBITORS. 138
DESIGN AND SYNTHESIS OF MELATONIN RECEPTORS AGONISTS AND ANTAGONISTS 138
Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity 138
Stereospecific Synthesis of N- (Diphenylmethylene)-α,β-didehydroamino Acid Methyl Esters from β-Hydroxy-α-amino Acids 137
A Versatile Biomimetic Approach to Diindolylmethane Derivatives as Potential Anticancer Agents 134
Melatonin, non-selective MT1/MT2 and selective MT2 receptor agonists: differential effects on the 24-hr vigilance states 133
SYNTHESIS, BINDING AFFINITY FOR THE MELATONIN RECEPTOR, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF NEW INDOLE-BASED MELATONIN ANALOGUES. 132
Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities 131
7-Substituted theophyllines. Part VI. N-[2-(4-Chlorophenoxy)-1-phenyl-alkyl]-alkylamido derivatives. 130
Melatonin antagonizes apoptosis via receptor interaction in U937 monocytic cell 130
Totale 18.400
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Categoria #
all - tutte 83.114
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 83.114
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.638 0 0 0 0 0 0 396 382 251 307 125 177
2020/20212.895 90 194 136 354 164 191 226 244 445 310 363 178
2021/20221.844 170 196 193 250 33 49 74 114 118 106 46 495
2022/20232.759 309 175 73 333 234 605 12 231 449 92 177 69
2023/2024787 58 69 32 99 55 133 47 56 85 63 23 67
2024/20251.763 188 149 636 156 107 225 302 0 0 0 0 0
Totale 23.973