IRIS
SPADONI, GILBERTO
 Distribuzione geografica
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Continente #
NA - Nord America 15.574
EU - Europa 9.006
AS - Asia 5.104
SA - Sud America 410
AF - Africa 78
Continente sconosciuto - Info sul continente non disponibili 24
OC - Oceania 22
AN - Antartide 1
Totale 30.219
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Nazione #
US - Stati Uniti d'America 15.418
GB - Regno Unito 2.972
CN - Cina 2.849
IT - Italia 1.492
UA - Ucraina 1.300
SG - Singapore 1.189
SE - Svezia 775
DE - Germania 563
FI - Finlandia 533
RU - Federazione Russa 520
TR - Turchia 519
BR - Brasile 330
IE - Irlanda 267
FR - Francia 164
VN - Vietnam 161
CA - Canada 118
NL - Olanda 115
IN - India 101
BE - Belgio 56
PL - Polonia 54
KR - Corea 48
JP - Giappone 45
ES - Italia 43
AR - Argentina 34
HK - Hong Kong 30
BD - Bangladesh 27
MX - Messico 26
AT - Austria 25
EU - Europa 20
RO - Romania 20
ID - Indonesia 19
ZA - Sudafrica 18
KE - Kenya 17
AU - Australia 16
EG - Egitto 15
PK - Pakistan 14
AE - Emirati Arabi Uniti 12
LT - Lituania 12
CH - Svizzera 11
AL - Albania 10
IL - Israele 10
IQ - Iraq 10
IR - Iran 10
PE - Perù 9
SA - Arabia Saudita 9
TG - Togo 9
MA - Marocco 8
DK - Danimarca 7
EC - Ecuador 7
EE - Estonia 7
HR - Croazia 7
CO - Colombia 6
CZ - Repubblica Ceca 6
KZ - Kazakistan 6
PY - Paraguay 6
BG - Bulgaria 5
CL - Cile 5
IS - Islanda 5
KG - Kirghizistan 5
A2 - ???statistics.table.value.countryCode.A2??? 4
AM - Armenia 4
GR - Grecia 4
LA - Repubblica Popolare Democratica del Laos 4
NP - Nepal 4
RS - Serbia 4
SI - Slovenia 4
SK - Slovacchia (Repubblica Slovacca) 4
VE - Venezuela 4
BO - Bolivia 3
HU - Ungheria 3
LV - Lettonia 3
MD - Moldavia 3
NZ - Nuova Zelanda 3
PA - Panama 3
PT - Portogallo 3
TW - Taiwan 3
UY - Uruguay 3
UZ - Uzbekistan 3
AZ - Azerbaigian 2
BY - Bielorussia 2
BZ - Belize 2
DO - Repubblica Dominicana 2
GE - Georgia 2
GU - Guam 2
JM - Giamaica 2
JO - Giordania 2
LB - Libano 2
LK - Sri Lanka 2
LU - Lussemburgo 2
OM - Oman 2
PH - Filippine 2
SM - San Marino 2
SY - Repubblica araba siriana 2
TH - Thailandia 2
TN - Tunisia 2
AO - Angola 1
BB - Barbados 1
BW - Botswana 1
ET - Etiopia 1
FK - Isole Falkland (Malvinas) 1
Totale 30.200
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Città #
Southend 2.686
Woodbridge 1.583
Fairfield 1.428
Dallas 1.326
Ashburn 1.201
Houston 1.158
Ann Arbor 1.087
Jacksonville 1.013
Chandler 899
Cambridge 648
Seattle 601
Wilmington 595
Singapore 523
Nanjing 521
Beijing 427
Izmir 359
Urbino 320
Boardman 273
Dublin 265
Nanchang 216
Los Angeles 203
Helsinki 197
New York 189
Chicago 168
San Mateo 166
Princeton 157
Shenyang 127
Munich 119
Düsseldorf 109
Hebei 108
Tianjin 108
Changsha 107
Des Moines 93
Istanbul 90
Jiaxing 85
Amsterdam 74
Moscow 68
Salt Lake City 68
Kunming 60
Velikiy Novgorod 59
Santa Clara 58
Brussels 55
Jinan 54
Bremen 52
Turku 52
Ho Chi Minh City 51
Shanghai 50
Toronto 49
San Diego 47
Buffalo 44
San Francisco 43
Seongnam 43
Guangzhou 41
São Paulo 41
London 40
Rome 40
Hangzhou 39
Warsaw 38
Tampa 37
Zhengzhou 37
Council Bluffs 36
Mülheim 36
Nuremberg 36
Elk Grove Village 35
Hanoi 34
Milan 34
Venice 34
Montreal 32
Changchun 30
Tokyo 30
Ningbo 27
Stockholm 27
Frankfurt am Main 26
Haikou 25
Phoenix 25
Wuppertal 23
Denver 22
Hong Kong 21
Bologna 20
Dong Ket 20
Poplar 20
Sterling 19
Augusta 18
Bellaria-Igea Marina 18
Dulles 18
Lanzhou 18
Monte Porzio 18
Auburn Hills 17
Chennai 17
Parma 17
Atlanta 16
Dearborn 16
Johannesburg 16
Lancaster 16
Lauterbourg 16
Norwalk 16
Boston 15
Brooklyn 15
Ancona 14
Osimo 14
Totale 21.302
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Nome #
1-(2-Alkylamidoethyl)-6-methoxyindole Derivatives: A New Class of Potent Indole Melatonin Analogues. 1.283
Industrial and academic approaches to the search for alternative melatonin receptor ligands: An historical survey. 672
1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID DERIVATIVES AS LIGANDS AT THE GLYCINE-BINDING SITE OF THE N-METHYL-D-ASPARTATE RECEPTOR 413
Iridium-Catalyzed Direct Synthesis of Tryptamine Derivatives from Indoles: Exploiting N-Protected β-Amino Alcohols as Alkylating Agents 366
Derivatizzazione one-pot di indoli per la sintesi di triptofani, pirroloindoline, bis-indoli & co 325
1-Aminocyclopropane-1-carboxylic acid derivatives: Synthesis and NMDA receptor complex binding affinity study. 311
1-Amminocyclopropane-1-Carboxylic Acid Derivatives: A New, General Synthesis and NMDA Receptor Complex Binding Affiniy Study 305
An improved synthesis of cis-4-phenyl-2-propionamidotetralin (4-P-PDOT): a selective MT2 melatonin receptor antagonist. 298
Synthesis of Tryptamine Derivatives via a Direct, One-Pot Reductive Alkylation of Indoles 287
A Novel One-Pot Approach of Hexahydropyrrolo[2,3-b]indole Nucleus by a cascade addition/cyclization strategy: Synthesis of (±)-Esermethole 286
Synthesis and Configuration Determination of All Enantiopure Stereoisomers of the Melatonin Receptor Ligand 4-Phenyl-2-propionamidotetralin using an Expedient Optical Resolution of 4-Phenyl-2-tetralone 284
Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012-2014) 283
Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties 278
Synthesis of 2-substituted tryptophans via a C3- to C2-alkyl migration 276
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis, Binding Affinity for Melatonin Receptor, and Evaluation of the Biological Activity 270
A New Synthesis of 2-Substituted DL-Tryptophan Derivatives 270
Synthesis and Characterization of New Bivalent Agents as Melatonin- and Histamine H3-Ligands 262
Design, synthesis and biological activity of hydrogen peroxide responsive arylboronate melatonin hybrids 261
A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties 260
(E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists. 257
3-(2-Carbamoylvinyl)-4,5-dimethylpyrrole-2-carboxylic acids as ligands at the NMDA glycine-binding site: a study on the 2-carbamoylvinyl chain modification 257
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 257
Tricyclic Alkylamides as Melatonin Receptor Ligands with Antagonist or Inverse Agonist Activity 254
Analogues of benzamide as poly(ADP-ribose)transferase inhibitors: a study on structure activity relationships. 253
Alkyl 2 (Diphenyl-methyleneamino) acrylates in the Synthesis of α-Amino Acids 252
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands 251
Direct, One-Pot Reductive Alkylation of Anilines with Functionalized Acetals Mediated by Triethylsilane and TFA. Straightforward Route for Unsymmetrically Substituted Ethylenediamine 250
Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines 250
Organocatalyzed coupling of indoles with dehydroalanine esters: synthesis of bis(indolyl)propanoates and indolacrylates 248
4,5-Dihydroisoxazole and 4,5-dihydro-1,2,4-oxadiazole derivatives from cycloaddition reactions of nitrile oxides to alkyl N-(diphenylmethylene)-α ,β -dehydroamino acids 247
Synthesis and Biological Activity of new melatonin dimeric derivatives. 235
Reassessing the melatonin pharmacophore: enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue. 234
Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit 232
2-Bromomelatonin: Synthesis and characterization of a potent melatonin agonist 229
Brønsted Acid-Catalyzed Bisindolization of α-amido acetals: Synthesis and Anticancer activity of bis(indolyl)ethanamino derivatives 225
POSITIVE ION-MASS SPECTRA AND COLLISION-INDUCED DISSOCIATION OF SOME 2,3-DIDEHYDRO AMINO ACIDS 223
2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists 222
N (Diphenylmethylene)-α,β−didehydroamino Acid Esters. Thermal and Lewis Acid Induced Dimerizations 220
Conformation by NMR of two tetralin-based receptor ligands 214
2,3-Dehydroamino acid derivatives as intermediates in the synthesis of heterocyclic compounds. 213
Reaction of Secondary Acetylenic Bromides with Sodium Nitrite: Synthesis of 3,5-Alkyl(aryl)-4-nitroisoxazoles 213
Selective Melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways 212
Toward the Definition of Stereochemical Requirements for MT(2)-Selective Antagonists and Partial Agonists by Studying 4-Phenyl-2-propionamidotetralin Derivatives 210
Structural requirements for inhibitors of poly(ADP-ribose) polymerase. 209
The rationale for the development of melatonin receptor ligands 209
5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors, preparation, and therapeutic use.. 209
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands. 209
Synthetic Melatonin Receptor Ligands 207
Synthesis and Structure–Activity Relationships of a Series of Pyrrole Cannabinoid Receptor Agonists 204
Bivalent Ligand Approach on N-[2-[(3-methoxyphenyl)methylamino]ethyl]acetamide. Synthesis, Binding Affinity and Intrinsic Acivity for MT(1) and MT(2) melatonin Receptors. 204
Differentiation between isomeric 1-aminocyclopropane-1-carboxylic acid derivatives by means of chemical ionisation and mass selected collision induced dissociation 203
Substituted Benzamides as Poly(ADP-Ribose) transferase Inhibitors: Development of new Derivatives by using Computer Graphics Techniques 202
Pharmacokinetic and pharmacodynamic evaluation of ramelteon : an insomnia therapy 202
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 202
Diastereo- and enantioselective hydrogenation of a challenging enamide derived from 4-phenyl-2-tetralone: an appealing shortcut towards enantiopure cis-2-aminotetraline derivatives 202
(E)-3-[2-(Carbamoylvinyl)]pyrrol-2-carboxylic acid derivatives: A novel Class of glycine site Antagonists. 201
Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle 201
New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an in Vivo BRET-Based Discovery Platform 199
Conformationally Restrained Melatonin Analogs: Synthesis, Binding Affinity for the Melatonin Receptor, Evaluation of the Biological Activity, and Molecular Modeling Study 197
Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand 197
Design and synthesis of N-[3,3-diphenyl-propenyl]alkanamides as a novel class of potent MT2-selective Melatonin receptor ligands 196
N-(Substituted-anilinoethyl)acylamides: Design, Synthesis and Pharmacological Characterization of a New Class of Melatonin Receptor Ligands 196
N-(DIPHENYLMETHYLENE)-ALPHA,BETA-DIDEHYDROAMINO ACID ESTERS. THERMAL AND LEWIS ACID INDUCED DIMERIZATIONS 195
Synthesis, Enantiomeric Resolution and Structure-Activity Relationship Study for a Series of 10,11-Dihydro-5H-dibenzo[a,d]cycloheptene MT2 Receptor Antagonists. 195
N-acetiltriptamine 2,5-sostituite: sintesi e valutazione dell’attività biologica per i recettori melatoninergici MT1 e MT2 194
N-Acyl-5- and -2,5-substituted tryptamines: synthesis, activity and affinity for human mt1 and MT2 melatonin receptors 192
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis and Binding Affinity to the Melatonin Receptor 191
SYNTHESIS, BINDING AFFINITY FOR THE MELATONIN RECEPTOR, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF NEW INDOLE-BASED MELATONIN ANALOGUES. 191
2-N-Acylaminoalkylindoles: Design and Quantitative Structure-Activity Relationship Studies Leading to MT2-Selective Antagonists. 190
Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells 188
MELATONIN RECEPTOR AGONISTS: SAR AND APPLICATIONS TO THE TREATMENT OF SLEEP-WAKE DISORDERS 187
Alchilammidi tricicliche: legandi selettivi dei recettori melatoninergici MT1 e MT2 186
Homology models of melatonin receptors: challenges and recent advances 185
ANALOGUES OF BENZAMIDE CONTAINING A SULPHUR ATOM AS POLY(ADP-ribose)TRANSFERASE INHIBITORS. 184
Substituent effects on 1,3-dipolar cycloadditions to some 1,1-diphenyl-2-aza-1,3-butadiene derivatives 183
Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors 183
A Versatile Biomimetic Approach to Diindolylmethane Derivatives as Potential Anticancer Agents 182
2-Arylmelatonin analogues: Probing the 2-phenyl binding pocket of melatonin MT1 and MT2 receptors 181
Metastable ion studies in the characterization melatonin isomers 177
STRUCTURE-AFFINITY RELATIONSHIPS OF INDOLE-BASED MELATONIN ANALOGS 176
The Hypnotic and Analgesic Effects of 2-Bromomelatonin 175
THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON SELECTED MT1 AND MT2 MELATONIN RECEPTOR LIGANDS: REQUIREMENTS FOR SUBTYPE SELECTIVITY AND INTRINSIC ACTIVITY MODULATION 174
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice 174
Synthesis and conformational study of 3,4-carbocyclic bridged indole melatonin and serotonin analogues 173
Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam 172
A novel melatonin partial agonist with sleep-promoting properties 170
7-Substituted theophyllines. Part VI. N-[2-(4-Chlorophenoxy)-1-phenyl-alkyl]-alkylamido derivatives. 170
Recent advances in the development of melatonin MT1 and MT2 receptor agonists 169
Description of the constitutive activity of cloned human melatonin receptors hMT1 and hMT2 and discovery of inverse agonists 168
Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study. 168
Reactions of 3-Carbomethoxy-2-aza-1,3-Butadiene Derivatives with Dienophiles 167
Strategies leading to MT2 selective melatonin receptor antagonists 165
Derivati 2-Acilamminoalchilindolici come Antagonisti/Agonisti Parziali della Melatonina 165
Melatonin receptor agonists: new options for insomnia and depression treatment 165
Melatonin antagonizes apoptosis via receptor interaction in U937 monocytic cell 164
Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models 162
Strategies leading to MT2 selective melatonin receptor antagonists 160
Progettazione e Sintesi di nuovi ligandi dei recettori MT1 e MT2 della melatonina a struttura difenilalchilammidica. 159
2-5-Disubstituted tryptamines a selective serotonin 5HT6 receptor agonists. 156
Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity 156
Totale 23.189
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Categoria #
all - tutte 105.860
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 105.860
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.957 0 0 0 0 0 191 226 244 445 310 363 178
2021/20221.844 170 196 193 250 33 49 74 114 118 106 46 495
2022/20232.759 309 175 73 333 234 605 12 231 449 92 177 69
2023/2024787 58 69 32 99 55 133 47 56 85 63 23 67
2024/20253.678 188 149 636 156 107 225 405 149 249 230 359 825
2025/20264.655 656 875 1.376 1.126 590 32 0 0 0 0 0 0
Totale 30.543