IRIS
SPADONI, GILBERTO
 Distribuzione geografica
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Continente #
NA - Nord America 11.606
EU - Europa 7.743
AS - Asia 2.393
Continente sconosciuto - Info sul continente non disponibili 24
SA - Sud America 21
AF - Africa 20
OC - Oceania 17
AN - Antartide 1
Totale 21.825
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Nazione #
US - Stati Uniti d'America 11.543
GB - Regno Unito 2.906
CN - Cina 1.792
IT - Italia 1.307
UA - Ucraina 1.292
SE - Svezia 753
FI - Finlandia 467
DE - Germania 380
TR - Turchia 370
IE - Irlanda 267
FR - Francia 99
RU - Federazione Russa 84
IN - India 66
CA - Canada 60
KR - Corea 47
BE - Belgio 42
NL - Olanda 25
VN - Vietnam 25
SG - Singapore 23
JP - Giappone 21
ES - Italia 20
EU - Europa 20
RO - Romania 18
PL - Polonia 17
AU - Australia 14
BR - Brasile 12
CH - Svizzera 10
HK - Hong Kong 10
TG - Togo 9
EG - Egitto 8
IR - Iran 8
HR - Croazia 7
AL - Albania 6
DK - Danimarca 6
PK - Pakistan 6
EE - Estonia 5
A2 - ???statistics.table.value.countryCode.A2??? 4
AT - Austria 4
BG - Bulgaria 4
ID - Indonesia 4
SI - Slovenia 4
BD - Bangladesh 3
HU - Ungheria 3
IL - Israele 3
IQ - Iraq 3
LA - Repubblica Popolare Democratica del Laos 3
RS - Serbia 3
AM - Armenia 2
AR - Argentina 2
BO - Bolivia 2
BY - Bielorussia 2
CZ - Repubblica Ceca 2
GR - Grecia 2
GU - Guam 2
IS - Islanda 2
LB - Libano 2
PA - Panama 2
PE - Perù 2
SK - Slovacchia (Repubblica Slovacca) 2
TW - Taiwan 2
AE - Emirati Arabi Uniti 1
CL - Cile 1
FK - Isole Falkland (Malvinas) 1
GS - Georgia del Sud e Isole Sandwich Australi 1
IM - Isola di Man 1
LU - Lussemburgo 1
MA - Marocco 1
MD - Moldavia 1
MX - Messico 1
NZ - Nuova Zelanda 1
PT - Portogallo 1
PY - Paraguay 1
SA - Arabia Saudita 1
SL - Sierra Leone 1
TH - Thailandia 1
ZA - Sudafrica 1
Totale 21.825
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Città #
Southend 2.686
Woodbridge 1.583
Fairfield 1.428
Houston 1.145
Ann Arbor 1.087
Jacksonville 1.012
Chandler 899
Ashburn 684
Cambridge 648
Seattle 590
Wilmington 577
Nanjing 521
Izmir 359
Urbino 282
Dublin 265
Nanchang 215
Helsinki 186
San Mateo 166
Princeton 157
Beijing 145
Shenyang 127
New York 109
Hebei 108
Changsha 102
Tianjin 102
Düsseldorf 85
Jiaxing 77
Boardman 68
Kunming 60
Velikiy Novgorod 59
Des Moines 56
Jinan 54
Bremen 52
San Diego 46
Seongnam 43
Brussels 41
Toronto 38
Mülheim 36
Venice 34
Zhengzhou 34
Hangzhou 33
San Francisco 30
Milan 28
Changchun 27
Ningbo 27
London 26
Haikou 25
Rome 24
Wuppertal 23
Shanghai 21
Bologna 20
Dong Ket 20
Los Angeles 20
Lanzhou 18
Monte Porzio 18
Auburn Hills 17
Guangzhou 17
Parma 17
Dearborn 16
Norwalk 16
Augusta 15
Redwood City 14
Tavullia 13
Osimo 12
Frankfurt am Main 11
Leawood 11
Portland 11
Taizhou 11
Ancona 10
Mcallen 10
Munich 10
Ascoli Piceno 9
Borås 9
Lomé 9
Rimini 9
Taranto 9
Fuzhou 8
Naples 8
Orange 8
Orciano Di Pesaro 8
Pesaro 8
Scottsdale 8
West Jordan 8
Acquasanta Terme 7
Angri 7
Edinburgh 7
Hefei 7
Melbourne 7
Singapore 7
São Paulo 7
Tokyo 7
Acton 6
Berlin 6
Dormagen 6
Florence 6
Focsani 6
Kilburn 6
Monmouth Junction 6
Nuremberg 6
Prescot 6
Totale 16.748
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Nome #
Iridium-Catalyzed Direct Synthesis of Tryptamine Derivatives from Indoles: Exploiting N-Protected β-Amino Alcohols as Alkylating Agents 309
1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID DERIVATIVES AS LIGANDS AT THE GLYCINE-BINDING SITE OF THE N-METHYL-D-ASPARTATE RECEPTOR 303
1-(2-Alkylamidoethyl)-6-methoxyindole Derivatives: A New Class of Potent Indole Melatonin Analogues. 298
1-Aminocyclopropane-1-carboxylic acid derivatives: Synthesis and NMDA receptor complex binding affinity study. 249
Synthesis of 2-substituted tryptophans via a C3- to C2-alkyl migration 243
Synthesis of Tryptamine Derivatives via a Direct, One-Pot Reductive Alkylation of Indoles 237
Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties 229
Derivatizzazione one-pot di indoli per la sintesi di triptofani, pirroloindoline, bis-indoli & co 226
Tricyclic Alkylamides as Melatonin Receptor Ligands with Antagonist or Inverse Agonist Activity 222
Organocatalyzed coupling of indoles with dehydroalanine esters: synthesis of bis(indolyl)propanoates and indolacrylates 222
An improved synthesis of cis-4-phenyl-2-propionamidotetralin (4-P-PDOT): a selective MT2 melatonin receptor antagonist. 221
1-Amminocyclopropane-1-Carboxylic Acid Derivatives: A New, General Synthesis and NMDA Receptor Complex Binding Affiniy Study 220
Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012-2014) 220
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 219
Direct, One-Pot Reductive Alkylation of Anilines with Functionalized Acetals Mediated by Triethylsilane and TFA. Straightforward Route for Unsymmetrically Substituted Ethylenediamine 218
Synthesis and Configuration Determination of All Enantiopure Stereoisomers of the Melatonin Receptor Ligand 4-Phenyl-2-propionamidotetralin using an Expedient Optical Resolution of 4-Phenyl-2-tetralone 212
A Novel One-Pot Approach of Hexahydropyrrolo[2,3-b]indole Nucleus by a cascade addition/cyclization strategy: Synthesis of (±)-Esermethole 210
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis, Binding Affinity for Melatonin Receptor, and Evaluation of the Biological Activity 207
Synthesis and Characterization of New Bivalent Agents as Melatonin- and Histamine H3-Ligands 206
Synthesis and Biological Activity of new melatonin dimeric derivatives. 205
A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties 205
Alkyl 2 (Diphenyl-methyleneamino) acrylates in the Synthesis of α-Amino Acids 204
A New Synthesis of 2-Substituted DL-Tryptophan Derivatives 202
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands 201
POSITIVE ION-MASS SPECTRA AND COLLISION-INDUCED DISSOCIATION OF SOME 2,3-DIDEHYDRO AMINO ACIDS 197
Analogues of benzamide as poly(ADP-ribose)transferase inhibitors: a study on structure activity relationships. 196
(E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists. 196
Design, synthesis and biological activity of hydrogen peroxide responsive arylboronate melatonin hybrids 190
4,5-Dihydroisoxazole and 4,5-dihydro-1,2,4-oxadiazole derivatives from cycloaddition reactions of nitrile oxides to alkyl N-(diphenylmethylene)-α ,β -dehydroamino acids 189
3-(2-Carbamoylvinyl)-4,5-dimethylpyrrole-2-carboxylic acids as ligands at the NMDA glycine-binding site: a study on the 2-carbamoylvinyl chain modification 184
Synthetic Melatonin Receptor Ligands 184
Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines 184
Structural requirements for inhibitors of poly(ADP-ribose) polymerase. 183
The rationale for the development of melatonin receptor ligands 182
Toward the Definition of Stereochemical Requirements for MT(2)-Selective Antagonists and Partial Agonists by Studying 4-Phenyl-2-propionamidotetralin Derivatives 182
Substituted Benzamides as Poly(ADP-Ribose) transferase Inhibitors: Development of new Derivatives by using Computer Graphics Techniques 180
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands. 179
Synthesis and Structure–Activity Relationships of a Series of Pyrrole Cannabinoid Receptor Agonists 178
2-Bromomelatonin: Synthesis and characterization of a potent melatonin agonist 177
Differentiation between isomeric 1-aminocyclopropane-1-carboxylic acid derivatives by means of chemical ionisation and mass selected collision induced dissociation 174
Pharmacokinetic and pharmacodynamic evaluation of ramelteon : an insomnia therapy 174
N (Diphenylmethylene)-α,β−didehydroamino Acid Esters. Thermal and Lewis Acid Induced Dimerizations 173
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 173
Reaction of Secondary Acetylenic Bromides with Sodium Nitrite: Synthesis of 3,5-Alkyl(aryl)-4-nitroisoxazoles 173
Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand 172
Conformation by NMR of two tetralin-based receptor ligands 169
Synthesis, Enantiomeric Resolution and Structure-Activity Relationship Study for a Series of 10,11-Dihydro-5H-dibenzo[a,d]cycloheptene MT2 Receptor Antagonists. 167
MELATONIN RECEPTOR AGONISTS: SAR AND APPLICATIONS TO THE TREATMENT OF SLEEP-WAKE DISORDERS 164
Substituent effects on 1,3-dipolar cycloadditions to some 1,1-diphenyl-2-aza-1,3-butadiene derivatives 164
New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an in Vivo BRET-Based Discovery Platform 164
Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit 163
Diastereo- and enantioselective hydrogenation of a challenging enamide derived from 4-phenyl-2-tetralone: an appealing shortcut towards enantiopure cis-2-aminotetraline derivatives 162
Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle 162
Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors 160
Brønsted Acid-Catalyzed Bisindolization of α-amido acetals: Synthesis and Anticancer activity of bis(indolyl)ethanamino derivatives 160
5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors, preparation, and therapeutic use.. 159
Reassessing the melatonin pharmacophore: enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue. 156
Selective Melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways 155
The Hypnotic and Analgesic Effects of 2-Bromomelatonin 153
Design and synthesis of N-[3,3-diphenyl-propenyl]alkanamides as a novel class of potent MT2-selective Melatonin receptor ligands 152
Conformationally Restrained Melatonin Analogs: Synthesis, Binding Affinity for the Melatonin Receptor, Evaluation of the Biological Activity, and Molecular Modeling Study 152
Bivalent Ligand Approach on N-[2-[(3-methoxyphenyl)methylamino]ethyl]acetamide. Synthesis, Binding Affinity and Intrinsic Acivity for MT(1) and MT(2) melatonin Receptors. 152
STRUCTURE-AFFINITY RELATIONSHIPS OF INDOLE-BASED MELATONIN ANALOGS 150
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice 150
2,3-Dehydroamino acid derivatives as intermediates in the synthesis of heterocyclic compounds. 150
Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells 150
Metastable ion studies in the characterization melatonin isomers 149
Derivati 2-Acilamminoalchilindolici come Antagonisti/Agonisti Parziali della Melatonina 149
Recent advances in the development of melatonin MT1 and MT2 receptor agonists 148
Description of the constitutive activity of cloned human melatonin receptors hMT1 and hMT2 and discovery of inverse agonists 148
Synthesis and conformational study of 3,4-carbocyclic bridged indole melatonin and serotonin analogues 147
N-(DIPHENYLMETHYLENE)-ALPHA,BETA-DIDEHYDROAMINO ACID ESTERS. THERMAL AND LEWIS ACID INDUCED DIMERIZATIONS 146
2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists 146
Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study. 145
Homology models of melatonin receptors: challenges and recent advances 145
THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON SELECTED MT1 AND MT2 MELATONIN RECEPTOR LIGANDS: REQUIREMENTS FOR SUBTYPE SELECTIVITY AND INTRINSIC ACTIVITY MODULATION 143
N-Acyl-5- and -2,5-substituted tryptamines: synthesis, activity and affinity for human mt1 and MT2 melatonin receptors 143
Reactions of 3-Carbomethoxy-2-aza-1,3-Butadiene Derivatives with Dienophiles 143
Alchilammidi tricicliche: legandi selettivi dei recettori melatoninergici MT1 e MT2 143
Strategies leading to MT2 selective melatonin receptor antagonists 142
Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam 142
Strategies leading to MT2 selective melatonin receptor antagonists 141
N-acetiltriptamine 2,5-sostituite: sintesi e valutazione dell’attività biologica per i recettori melatoninergici MT1 e MT2 140
Melatonin receptor agonists: new options for insomnia and depression treatment 140
N-(Substituted-anilinoethyl)acylamides: Design, Synthesis and Pharmacological Characterization of a New Class of Melatonin Receptor Ligands 138
Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models 138
(E)-3-[2-(Carbamoylvinyl)]pyrrol-2-carboxylic acid derivatives: A novel Class of glycine site Antagonists. 134
DESIGN AND SYNTHESIS OF MELATONIN RECEPTORS AGONISTS AND ANTAGONISTS 131
Short synthesis of tryptophan and β -carboline derivatives by reaction of indoles with N-(diphenylmethylene)-α ,β -didehydroamino acid esters 131
Progettazione e Sintesi di nuovi ligandi dei recettori MT1 e MT2 della melatonina a struttura difenilalchilammidica. 131
Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity 131
Stereospecific Synthesis of N- (Diphenylmethylene)-α,β-didehydroamino Acid Methyl Esters from β-Hydroxy-α-amino Acids 125
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis and Binding Affinity to the Melatonin Receptor 125
Melatonin, non-selective MT1/MT2 and selective MT2 receptor agonists: differential effects on the 24-hr vigilance states 125
Synthesis, Pharmacological Characterization and QSAR Studies on 2-Substituted Indole Melatonin Receptor Ligands 125
ANALOGUES OF BENZAMIDE CONTAINING A SULPHUR ATOM AS POLY(ADP-ribose)TRANSFERASE INHIBITORS. 124
Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities 124
SYNTHESIS, BINDING AFFINITY FOR THE MELATONIN RECEPTOR, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF NEW INDOLE-BASED MELATONIN ANALOGUES. 123
Derivati 1-Acilamminoalchilindolici come agonisti della melatonina. 122
Towards the development of mixed MT1-agonist/MT2-antagonist melatonin receptor ligands 121
Totale 17.270
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Categoria #
all - tutte 65.030
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 65.030
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/20191.199 0 0 0 0 0 0 0 0 0 0 361 838
2019/20204.918 958 198 318 1.119 264 423 396 382 251 307 125 177
2020/20212.895 90 194 136 354 164 191 226 244 445 310 363 178
2021/20221.844 170 196 193 250 33 49 74 114 118 106 46 495
2022/20232.759 309 175 73 333 234 605 12 231 449 92 177 69
2023/2024705 58 69 32 99 55 133 47 56 85 63 8 0
Totale 22.128