IRIS
SPADONI, GILBERTO
 Distribuzione geografica
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Continente #
NA - Nord America 17.195
EU - Europa 11.566
AS - Asia 5.819
SA - Sud America 491
AF - Africa 110
Continente sconosciuto - Info sul continente non disponibili 24
OC - Oceania 23
AN - Antartide 1
Totale 35.229
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Nazione #
US - Stati Uniti d'America 16.987
GB - Regno Unito 2.998
CN - Cina 2.966
NL - Olanda 2.012
IT - Italia 1.609
SG - Singapore 1.555
UA - Ucraina 1.307
SE - Svezia 784
RU - Federazione Russa 740
FI - Finlandia 604
DE - Germania 587
TR - Turchia 522
BR - Brasile 372
FR - Francia 315
IE - Irlanda 268
VN - Vietnam 241
CA - Canada 143
IN - India 126
PL - Polonia 62
HK - Hong Kong 59
BE - Belgio 56
JP - Giappone 52
KR - Corea 51
AR - Argentina 48
ES - Italia 46
BD - Bangladesh 40
MX - Messico 40
AT - Austria 26
IQ - Iraq 26
ZA - Sudafrica 24
EG - Egitto 23
ID - Indonesia 23
KE - Kenya 21
RO - Romania 21
EU - Europa 20
PK - Pakistan 20
AU - Australia 16
CO - Colombia 14
PE - Perù 14
AE - Emirati Arabi Uniti 13
LT - Lituania 13
PT - Portogallo 13
CH - Svizzera 12
IR - Iran 12
SA - Arabia Saudita 12
AL - Albania 11
CL - Cile 10
IL - Israele 10
MA - Marocco 10
DK - Danimarca 9
KZ - Kazakistan 9
MY - Malesia 9
TG - Togo 9
UZ - Uzbekistan 9
VE - Venezuela 9
NP - Nepal 8
BG - Bulgaria 7
EC - Ecuador 7
EE - Estonia 7
HR - Croazia 7
JM - Giamaica 7
JO - Giordania 7
KG - Kirghizistan 7
PH - Filippine 7
PY - Paraguay 7
CZ - Repubblica Ceca 6
GR - Grecia 5
IS - Islanda 5
MD - Moldavia 5
SK - Slovacchia (Repubblica Slovacca) 5
TN - Tunisia 5
TW - Taiwan 5
A2 - ???statistics.table.value.countryCode.A2??? 4
AM - Armenia 4
AZ - Azerbaigian 4
BO - Bolivia 4
BY - Bielorussia 4
CR - Costa Rica 4
LA - Repubblica Popolare Democratica del Laos 4
LV - Lettonia 4
NZ - Nuova Zelanda 4
RS - Serbia 4
SI - Slovenia 4
AO - Angola 3
HN - Honduras 3
HU - Ungheria 3
OM - Oman 3
PA - Panama 3
SY - Repubblica araba siriana 3
TH - Thailandia 3
UY - Uruguay 3
BZ - Belize 2
CI - Costa d'Avorio 2
DO - Repubblica Dominicana 2
DZ - Algeria 2
ET - Etiopia 2
GE - Georgia 2
GU - Guam 2
LB - Libano 2
LK - Sri Lanka 2
Totale 35.201
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Città #
Southend 2.686
Amsterdam 1.952
Woodbridge 1.583
Fairfield 1.428
Ashburn 1.383
Dallas 1.335
Houston 1.167
Ann Arbor 1.091
Jacksonville 1.015
Chandler 899
Singapore 791
San Jose 780
Cambridge 648
Seattle 602
Wilmington 596
Nanjing 522
Beijing 451
Izmir 360
Boardman 321
Urbino 320
Helsinki 267
Dublin 265
Los Angeles 230
New York 220
Nanchang 216
Council Bluffs 184
Chicago 176
San Mateo 166
Princeton 157
Lauterbourg 156
Shenyang 127
Munich 119
Tianjin 110
Changsha 109
Düsseldorf 109
Hebei 108
Des Moines 93
Istanbul 91
Jiaxing 85
Ho Chi Minh City 81
Santa Clara 78
Salt Lake City 71
Moscow 68
Kunming 60
Velikiy Novgorod 59
Brussels 55
Buffalo 54
Jinan 54
Orem 54
Hanoi 53
Toronto 53
Bremen 52
Shanghai 52
Turku 52
Hong Kong 49
São Paulo 49
San Diego 47
San Francisco 45
Warsaw 45
London 44
Rome 43
Seongnam 43
Frankfurt am Main 42
Guangzhou 42
Hangzhou 42
Elk Grove Village 40
Montreal 40
Nuremberg 40
Tampa 37
Zhengzhou 37
Mülheim 36
Tokyo 36
Venice 36
Milan 35
Stockholm 34
Chennai 31
Changchun 30
Ningbo 27
Phoenix 27
Denver 26
Haikou 25
Poplar 25
Wuppertal 23
Manchester 22
The Dalles 22
Brooklyn 21
Bologna 20
Dong Ket 20
Atlanta 19
Bellaria-Igea Marina 19
Johannesburg 19
Mexico City 19
Sterling 19
Augusta 18
Dulles 18
Lancaster 18
Lanzhou 18
Monte Porzio 18
Auburn Hills 17
Parma 17
Totale 25.214
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Nome #
1-(2-Alkylamidoethyl)-6-methoxyindole Derivatives: A New Class of Potent Indole Melatonin Analogues. 3.190
Industrial and academic approaches to the search for alternative melatonin receptor ligands: An historical survey. 709
Derivatizzazione one-pot di indoli per la sintesi di triptofani, pirroloindoline, bis-indoli & co 464
1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID DERIVATIVES AS LIGANDS AT THE GLYCINE-BINDING SITE OF THE N-METHYL-D-ASPARTATE RECEPTOR 433
Iridium-Catalyzed Direct Synthesis of Tryptamine Derivatives from Indoles: Exploiting N-Protected β-Amino Alcohols as Alkylating Agents 391
1-Aminocyclopropane-1-carboxylic acid derivatives: Synthesis and NMDA receptor complex binding affinity study. 336
Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012-2014) 332
1-Amminocyclopropane-1-Carboxylic Acid Derivatives: A New, General Synthesis and NMDA Receptor Complex Binding Affiniy Study 330
An improved synthesis of cis-4-phenyl-2-propionamidotetralin (4-P-PDOT): a selective MT2 melatonin receptor antagonist. 327
Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties 311
A Novel One-Pot Approach of Hexahydropyrrolo[2,3-b]indole Nucleus by a cascade addition/cyclization strategy: Synthesis of (±)-Esermethole 309
Synthesis and Configuration Determination of All Enantiopure Stereoisomers of the Melatonin Receptor Ligand 4-Phenyl-2-propionamidotetralin using an Expedient Optical Resolution of 4-Phenyl-2-tetralone 303
Synthesis of Tryptamine Derivatives via a Direct, One-Pot Reductive Alkylation of Indoles 300
Design, synthesis and biological activity of hydrogen peroxide responsive arylboronate melatonin hybrids 297
A New Synthesis of 2-Substituted DL-Tryptophan Derivatives 289
Synthesis of 2-substituted tryptophans via a C3- to C2-alkyl migration 286
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis, Binding Affinity for Melatonin Receptor, and Evaluation of the Biological Activity 285
3-(2-Carbamoylvinyl)-4,5-dimethylpyrrole-2-carboxylic acids as ligands at the NMDA glycine-binding site: a study on the 2-carbamoylvinyl chain modification 283
(E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists. 281
Tricyclic Alkylamides as Melatonin Receptor Ligands with Antagonist or Inverse Agonist Activity 277
Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines 277
Synthesis and Characterization of New Bivalent Agents as Melatonin- and Histamine H3-Ligands 276
A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties 274
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 274
Synthesis and Biological Activity of new melatonin dimeric derivatives. 273
4,5-Dihydroisoxazole and 4,5-dihydro-1,2,4-oxadiazole derivatives from cycloaddition reactions of nitrile oxides to alkyl N-(diphenylmethylene)-α ,β -dehydroamino acids 273
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands 273
Selective Melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways 269
Analogues of benzamide as poly(ADP-ribose)transferase inhibitors: a study on structure activity relationships. 268
Alkyl 2 (Diphenyl-methyleneamino) acrylates in the Synthesis of α-Amino Acids 268
Direct, One-Pot Reductive Alkylation of Anilines with Functionalized Acetals Mediated by Triethylsilane and TFA. Straightforward Route for Unsymmetrically Substituted Ethylenediamine 267
Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit 260
Organocatalyzed coupling of indoles with dehydroalanine esters: synthesis of bis(indolyl)propanoates and indolacrylates 256
Reassessing the melatonin pharmacophore: enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue. 253
2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists 247
2-Bromomelatonin: Synthesis and characterization of a potent melatonin agonist 246
Brønsted Acid-Catalyzed Bisindolization of α-amido acetals: Synthesis and Anticancer activity of bis(indolyl)ethanamino derivatives 239
N (Diphenylmethylene)-α,β−didehydroamino Acid Esters. Thermal and Lewis Acid Induced Dimerizations 237
2-Arylmelatonin analogues: Probing the 2-phenyl binding pocket of melatonin MT1 and MT2 receptors 236
POSITIVE ION-MASS SPECTRA AND COLLISION-INDUCED DISSOCIATION OF SOME 2,3-DIDEHYDRO AMINO ACIDS 236
2,3-Dehydroamino acid derivatives as intermediates in the synthesis of heterocyclic compounds. 233
N-(Substituted-anilinoethyl)acylamides: Design, Synthesis and Pharmacological Characterization of a New Class of Melatonin Receptor Ligands 230
Conformation by NMR of two tetralin-based receptor ligands 226
The rationale for the development of melatonin receptor ligands 226
5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors, preparation, and therapeutic use.. 226
Bivalent Ligand Approach on N-[2-[(3-methoxyphenyl)methylamino]ethyl]acetamide. Synthesis, Binding Affinity and Intrinsic Acivity for MT(1) and MT(2) melatonin Receptors. 225
Reaction of Secondary Acetylenic Bromides with Sodium Nitrite: Synthesis of 3,5-Alkyl(aryl)-4-nitroisoxazoles 225
Diastereo- and enantioselective hydrogenation of a challenging enamide derived from 4-phenyl-2-tetralone: an appealing shortcut towards enantiopure cis-2-aminotetraline derivatives 225
Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle 223
Structural requirements for inhibitors of poly(ADP-ribose) polymerase. 221
Design and synthesis of N-[3,3-diphenyl-propenyl]alkanamides as a novel class of potent MT2-selective Melatonin receptor ligands 221
(E)-3-[2-(Carbamoylvinyl)]pyrrol-2-carboxylic acid derivatives: A novel Class of glycine site Antagonists. 221
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands. 220
Synthetic Melatonin Receptor Ligands 220
Pharmacokinetic and pharmacodynamic evaluation of ramelteon : an insomnia therapy 218
N-(DIPHENYLMETHYLENE)-ALPHA,BETA-DIDEHYDROAMINO ACID ESTERS. THERMAL AND LEWIS ACID INDUCED DIMERIZATIONS 217
Toward the Definition of Stereochemical Requirements for MT(2)-Selective Antagonists and Partial Agonists by Studying 4-Phenyl-2-propionamidotetralin Derivatives 217
Synthesis and Structure–Activity Relationships of a Series of Pyrrole Cannabinoid Receptor Agonists 215
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 215
Differentiation between isomeric 1-aminocyclopropane-1-carboxylic acid derivatives by means of chemical ionisation and mass selected collision induced dissociation 214
N-acetiltriptamine 2,5-sostituite: sintesi e valutazione dell’attività biologica per i recettori melatoninergici MT1 e MT2 214
Conformationally Restrained Melatonin Analogs: Synthesis, Binding Affinity for the Melatonin Receptor, Evaluation of the Biological Activity, and Molecular Modeling Study 214
N-Acyl-5- and -2,5-substituted tryptamines: synthesis, activity and affinity for human mt1 and MT2 melatonin receptors 213
A Versatile Biomimetic Approach to Diindolylmethane Derivatives as Potential Anticancer Agents 213
New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an in Vivo BRET-Based Discovery Platform 213
Synthesis, Enantiomeric Resolution and Structure-Activity Relationship Study for a Series of 10,11-Dihydro-5H-dibenzo[a,d]cycloheptene MT2 Receptor Antagonists. 212
Substituted Benzamides as Poly(ADP-Ribose) transferase Inhibitors: Development of new Derivatives by using Computer Graphics Techniques 210
Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand 210
2-N-Acylaminoalkylindoles: Design and Quantitative Structure-Activity Relationship Studies Leading to MT2-Selective Antagonists. 209
Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells 208
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis and Binding Affinity to the Melatonin Receptor 206
Homology models of melatonin receptors: challenges and recent advances 204
MELATONIN RECEPTOR AGONISTS: SAR AND APPLICATIONS TO THE TREATMENT OF SLEEP-WAKE DISORDERS 202
SYNTHESIS, BINDING AFFINITY FOR THE MELATONIN RECEPTOR, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF NEW INDOLE-BASED MELATONIN ANALOGUES. 200
Alchilammidi tricicliche: legandi selettivi dei recettori melatoninergici MT1 e MT2 199
ANALOGUES OF BENZAMIDE CONTAINING A SULPHUR ATOM AS POLY(ADP-ribose)TRANSFERASE INHIBITORS. 196
Metastable ion studies in the characterization melatonin isomers 193
Substituent effects on 1,3-dipolar cycloadditions to some 1,1-diphenyl-2-aza-1,3-butadiene derivatives 191
Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam 189
Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors 188
A novel melatonin partial agonist with sleep-promoting properties 187
The Hypnotic and Analgesic Effects of 2-Bromomelatonin 186
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice 186
7-Substituted theophyllines. Part VI. N-[2-(4-Chlorophenoxy)-1-phenyl-alkyl]-alkylamido derivatives. 186
Melatonin antagonizes apoptosis via receptor interaction in U937 monocytic cell 185
THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON SELECTED MT1 AND MT2 MELATONIN RECEPTOR LIGANDS: REQUIREMENTS FOR SUBTYPE SELECTIVITY AND INTRINSIC ACTIVITY MODULATION 184
Strategies leading to MT2 selective melatonin receptor antagonists 184
Synthesis and conformational study of 3,4-carbocyclic bridged indole melatonin and serotonin analogues 183
STRUCTURE-AFFINITY RELATIONSHIPS OF INDOLE-BASED MELATONIN ANALOGS 182
Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study. 181
Reactions of 3-Carbomethoxy-2-aza-1,3-Butadiene Derivatives with Dienophiles 179
Recent advances in the development of melatonin MT1 and MT2 receptor agonists 178
2-5-Disubstituted tryptamines a selective serotonin 5HT6 receptor agonists. 177
Description of the constitutive activity of cloned human melatonin receptors hMT1 and hMT2 and discovery of inverse agonists 177
Derivati 2-Acilamminoalchilindolici come Antagonisti/Agonisti Parziali della Melatonina 177
Progettazione e Sintesi di nuovi ligandi dei recettori MT1 e MT2 della melatonina a struttura difenilalchilammidica. 176
Strategies leading to MT2 selective melatonin receptor antagonists 175
Melatonin receptor agonists: new options for insomnia and depression treatment 173
Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity 172
Melatonin, non-selective MT1/MT2 and selective MT2 receptor agonists: differential effects on the 24-hr vigilance states 172
Totale 27.057
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Categoria #
all - tutte 117.003
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 117.003
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021178 0 0 0 0 0 0 0 0 0 0 0 178
2021/20221.844 170 196 193 250 33 49 74 114 118 106 46 495
2022/20232.759 309 175 73 333 234 605 12 231 449 92 177 69
2023/2024787 58 69 32 99 55 133 47 56 85 63 23 67
2024/20253.678 188 149 636 156 107 225 405 149 249 230 359 825
2025/20269.666 656 875 1.376 1.126 590 534 948 253 2.275 551 364 118
Totale 35.554