IRIS
SPADONI, GILBERTO
 Distribuzione geografica
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Continente #
NA - Nord America 18.681
EU - Europa 11.730
AS - Asia 5.913
SA - Sud America 537
Continente sconosciuto - Info sul continente non disponibili 357
AF - Africa 112
OC - Oceania 24
AN - Antartide 1
Totale 37.355
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Nazione #
US - Stati Uniti d'America 18.350
GB - Regno Unito 3.026
CN - Cina 2.990
NL - Olanda 2.016
IT - Italia 1.715
SG - Singapore 1.579
UA - Ucraina 1.307
SE - Svezia 785
RU - Federazione Russa 742
FI - Finlandia 604
DE - Germania 590
TR - Turchia 522
BR - Brasile 391
FR - Francia 317
IE - Irlanda 268
VN - Vietnam 246
CA - Canada 198
IN - India 126
HK - Hong Kong 67
PL - Polonia 64
BE - Belgio 57
JP - Giappone 55
AR - Argentina 53
KR - Corea 52
BD - Bangladesh 51
ES - Italia 48
MX - Messico 48
ID - Indonesia 29
IQ - Iraq 27
AT - Austria 26
CO - Colombia 24
ZA - Sudafrica 24
EG - Egitto 23
KE - Kenya 21
RO - Romania 21
EU - Europa 20
PK - Pakistan 20
AU - Australia 17
CR - Costa Rica 16
MY - Malesia 15
PT - Portogallo 15
HN - Honduras 14
JM - Giamaica 14
LT - Lituania 14
PE - Perù 14
SA - Arabia Saudita 14
AE - Emirati Arabi Uniti 13
AL - Albania 13
CH - Svizzera 13
VE - Venezuela 13
CL - Cile 12
EE - Estonia 12
IR - Iran 12
EC - Ecuador 11
DK - Danimarca 10
IL - Israele 10
MA - Marocco 10
KZ - Kazakistan 9
PH - Filippine 9
TG - Togo 9
UZ - Uzbekistan 9
NI - Nicaragua 8
NP - Nepal 8
BG - Bulgaria 7
HR - Croazia 7
JO - Giordania 7
KG - Kirghizistan 7
PY - Paraguay 7
CW - ???statistics.table.value.countryCode.CW??? 6
CZ - Repubblica Ceca 6
PA - Panama 6
BO - Bolivia 5
GR - Grecia 5
IS - Islanda 5
MD - Moldavia 5
SK - Slovacchia (Repubblica Slovacca) 5
SV - El Salvador 5
TN - Tunisia 5
TW - Taiwan 5
A2 - ???statistics.table.value.countryCode.A2??? 4
AM - Armenia 4
AZ - Azerbaigian 4
BY - Bielorussia 4
HU - Ungheria 4
LA - Repubblica Popolare Democratica del Laos 4
LV - Lettonia 4
NZ - Nuova Zelanda 4
PR - Porto Rico 4
RS - Serbia 4
SI - Slovenia 4
TH - Thailandia 4
TT - Trinidad e Tobago 4
AO - Angola 3
OM - Oman 3
SY - Repubblica araba siriana 3
UY - Uruguay 3
BF - Burkina Faso 2
BS - Bahamas 2
BZ - Belize 2
CI - Costa d'Avorio 2
Totale 36.981
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Città #
Southend 2.686
Amsterdam 1.952
Ashburn 1.624
Woodbridge 1.583
Fairfield 1.428
Dallas 1.365
Houston 1.172
Ann Arbor 1.091
Jacksonville 1.015
Chandler 900
San Jose 886
Singapore 806
Cambridge 650
Seattle 603
Wilmington 598
Nanjing 522
Beijing 465
Boardman 375
Izmir 360
Urbino 322
Council Bluffs 312
Helsinki 267
Dublin 265
Los Angeles 251
New York 232
Nanchang 216
Chicago 203
San Mateo 166
Princeton 159
Lauterbourg 156
Santa Clara 143
Shenyang 127
Munich 119
Tianjin 110
Changsha 109
Düsseldorf 109
Hebei 108
Des Moines 94
Istanbul 91
Jiaxing 85
Ho Chi Minh City 83
Salt Lake City 73
Moscow 68
Toronto 67
Kunming 60
Orem 59
Velikiy Novgorod 59
São Paulo 58
Buffalo 57
Hong Kong 57
San Francisco 56
Brussels 55
Hanoi 55
Jinan 54
Shanghai 54
Bremen 52
Turku 52
Milan 48
Montreal 48
Rome 48
San Diego 48
London 46
Warsaw 45
Seongnam 43
Frankfurt am Main 42
Guangzhou 42
Hangzhou 42
Elk Grove Village 40
Nuremberg 40
Phoenix 39
Tampa 39
Tokyo 39
Zhengzhou 37
Mülheim 36
Venice 36
Stockholm 34
Brooklyn 32
Denver 32
Chennai 31
North Bergen 31
Changchun 30
Ningbo 27
Haikou 25
Poplar 25
Atlanta 23
Mexico City 23
The Dalles 23
Wuppertal 23
Bologna 22
Manchester 22
Augusta 21
Dong Ket 20
Naples 20
Bellaria-Igea Marina 19
Johannesburg 19
Sterling 19
Boston 18
Dulles 18
Lancaster 18
Lanzhou 18
Totale 26.095
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Nome #
1-(2-Alkylamidoethyl)-6-methoxyindole Derivatives: A New Class of Potent Indole Melatonin Analogues. 3.214
Industrial and academic approaches to the search for alternative melatonin receptor ligands: An historical survey. 725
Derivatizzazione one-pot di indoli per la sintesi di triptofani, pirroloindoline, bis-indoli & co 506
1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID DERIVATIVES AS LIGANDS AT THE GLYCINE-BINDING SITE OF THE N-METHYL-D-ASPARTATE RECEPTOR 443
Iridium-Catalyzed Direct Synthesis of Tryptamine Derivatives from Indoles: Exploiting N-Protected β-Amino Alcohols as Alkylating Agents 400
Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012-2014) 397
1-Aminocyclopropane-1-carboxylic acid derivatives: Synthesis and NMDA receptor complex binding affinity study. 345
An improved synthesis of cis-4-phenyl-2-propionamidotetralin (4-P-PDOT): a selective MT2 melatonin receptor antagonist. 341
1-Amminocyclopropane-1-Carboxylic Acid Derivatives: A New, General Synthesis and NMDA Receptor Complex Binding Affiniy Study 337
Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties 320
A Novel One-Pot Approach of Hexahydropyrrolo[2,3-b]indole Nucleus by a cascade addition/cyclization strategy: Synthesis of (±)-Esermethole 319
Design, synthesis and biological activity of hydrogen peroxide responsive arylboronate melatonin hybrids 311
Synthesis of Tryptamine Derivatives via a Direct, One-Pot Reductive Alkylation of Indoles 309
Synthesis and Configuration Determination of All Enantiopure Stereoisomers of the Melatonin Receptor Ligand 4-Phenyl-2-propionamidotetralin using an Expedient Optical Resolution of 4-Phenyl-2-tetralone 306
Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines 300
(E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists. 298
A New Synthesis of 2-Substituted DL-Tryptophan Derivatives 293
3-(2-Carbamoylvinyl)-4,5-dimethylpyrrole-2-carboxylic acids as ligands at the NMDA glycine-binding site: a study on the 2-carbamoylvinyl chain modification 293
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis, Binding Affinity for Melatonin Receptor, and Evaluation of the Biological Activity 292
Synthesis of 2-substituted tryptophans via a C3- to C2-alkyl migration 290
Selective Melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways 288
Tricyclic Alkylamides as Melatonin Receptor Ligands with Antagonist or Inverse Agonist Activity 286
Synthesis and Characterization of New Bivalent Agents as Melatonin- and Histamine H3-Ligands 284
A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties 284
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 284
Synthesis and Biological Activity of new melatonin dimeric derivatives. 282
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands 282
4,5-Dihydroisoxazole and 4,5-dihydro-1,2,4-oxadiazole derivatives from cycloaddition reactions of nitrile oxides to alkyl N-(diphenylmethylene)-α ,β -dehydroamino acids 279
Analogues of benzamide as poly(ADP-ribose)transferase inhibitors: a study on structure activity relationships. 277
Direct, One-Pot Reductive Alkylation of Anilines with Functionalized Acetals Mediated by Triethylsilane and TFA. Straightforward Route for Unsymmetrically Substituted Ethylenediamine 275
Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit 273
2-Arylmelatonin analogues: Probing the 2-phenyl binding pocket of melatonin MT1 and MT2 receptors 272
Alkyl 2 (Diphenyl-methyleneamino) acrylates in the Synthesis of α-Amino Acids 271
Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle 270
2-Bromomelatonin: Synthesis and characterization of a potent melatonin agonist 266
Organocatalyzed coupling of indoles with dehydroalanine esters: synthesis of bis(indolyl)propanoates and indolacrylates 262
Reassessing the melatonin pharmacophore: enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue. 259
N-(Substituted-anilinoethyl)acylamides: Design, Synthesis and Pharmacological Characterization of a New Class of Melatonin Receptor Ligands 254
2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists 253
Brønsted Acid-Catalyzed Bisindolization of α-amido acetals: Synthesis and Anticancer activity of bis(indolyl)ethanamino derivatives 246
POSITIVE ION-MASS SPECTRA AND COLLISION-INDUCED DISSOCIATION OF SOME 2,3-DIDEHYDRO AMINO ACIDS 243
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands. 242
N (Diphenylmethylene)-α,β−didehydroamino Acid Esters. Thermal and Lewis Acid Induced Dimerizations 242
2,3-Dehydroamino acid derivatives as intermediates in the synthesis of heterocyclic compounds. 239
Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand 233
Conformation by NMR of two tetralin-based receptor ligands 232
Design and synthesis of N-[3,3-diphenyl-propenyl]alkanamides as a novel class of potent MT2-selective Melatonin receptor ligands 231
(E)-3-[2-(Carbamoylvinyl)]pyrrol-2-carboxylic acid derivatives: A novel Class of glycine site Antagonists. 231
Bivalent Ligand Approach on N-[2-[(3-methoxyphenyl)methylamino]ethyl]acetamide. Synthesis, Binding Affinity and Intrinsic Acivity for MT(1) and MT(2) melatonin Receptors. 231
Structural requirements for inhibitors of poly(ADP-ribose) polymerase. 230
N-acetiltriptamine 2,5-sostituite: sintesi e valutazione dell’attività biologica per i recettori melatoninergici MT1 e MT2 230
5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors, preparation, and therapeutic use.. 230
Diastereo- and enantioselective hydrogenation of a challenging enamide derived from 4-phenyl-2-tetralone: an appealing shortcut towards enantiopure cis-2-aminotetraline derivatives 230
The rationale for the development of melatonin receptor ligands 229
Reaction of Secondary Acetylenic Bromides with Sodium Nitrite: Synthesis of 3,5-Alkyl(aryl)-4-nitroisoxazoles 229
Conformationally Restrained Melatonin Analogs: Synthesis, Binding Affinity for the Melatonin Receptor, Evaluation of the Biological Activity, and Molecular Modeling Study 228
New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an in Vivo BRET-Based Discovery Platform 228
Differentiation between isomeric 1-aminocyclopropane-1-carboxylic acid derivatives by means of chemical ionisation and mass selected collision induced dissociation 227
Pharmacokinetic and pharmacodynamic evaluation of ramelteon : an insomnia therapy 224
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 223
Synthetic Melatonin Receptor Ligands 222
Synthesis and Structure–Activity Relationships of a Series of Pyrrole Cannabinoid Receptor Agonists 221
Toward the Definition of Stereochemical Requirements for MT(2)-Selective Antagonists and Partial Agonists by Studying 4-Phenyl-2-propionamidotetralin Derivatives 221
N-(DIPHENYLMETHYLENE)-ALPHA,BETA-DIDEHYDROAMINO ACID ESTERS. THERMAL AND LEWIS ACID INDUCED DIMERIZATIONS 220
2-N-Acylaminoalkylindoles: Design and Quantitative Structure-Activity Relationship Studies Leading to MT2-Selective Antagonists. 220
MT1-Selective Melatonin Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Dynamics Investigation of N-{[(3-O-Substituted)anilino]alkyl}amides 220
N-Acyl-5- and -2,5-substituted tryptamines: synthesis, activity and affinity for human mt1 and MT2 melatonin receptors 218
Synthesis, Enantiomeric Resolution and Structure-Activity Relationship Study for a Series of 10,11-Dihydro-5H-dibenzo[a,d]cycloheptene MT2 Receptor Antagonists. 217
A Versatile Biomimetic Approach to Diindolylmethane Derivatives as Potential Anticancer Agents 216
Homology models of melatonin receptors: challenges and recent advances 216
Substituted Benzamides as Poly(ADP-Ribose) transferase Inhibitors: Development of new Derivatives by using Computer Graphics Techniques 215
Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells 214
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis and Binding Affinity to the Melatonin Receptor 213
MELATONIN RECEPTOR AGONISTS: SAR AND APPLICATIONS TO THE TREATMENT OF SLEEP-WAKE DISORDERS 211
SYNTHESIS, BINDING AFFINITY FOR THE MELATONIN RECEPTOR, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF NEW INDOLE-BASED MELATONIN ANALOGUES. 210
Alchilammidi tricicliche: legandi selettivi dei recettori melatoninergici MT1 e MT2 208
ANALOGUES OF BENZAMIDE CONTAINING A SULPHUR ATOM AS POLY(ADP-ribose)TRANSFERASE INHIBITORS. 206
7-Substituted theophyllines. Part VI. N-[2-(4-Chlorophenoxy)-1-phenyl-alkyl]-alkylamido derivatives. 202
Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam 201
Melatonin antagonizes apoptosis via receptor interaction in U937 monocytic cell 201
Metastable ion studies in the characterization melatonin isomers 198
The Hypnotic and Analgesic Effects of 2-Bromomelatonin 197
Substituent effects on 1,3-dipolar cycloadditions to some 1,1-diphenyl-2-aza-1,3-butadiene derivatives 196
A novel melatonin partial agonist with sleep-promoting properties 194
THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON SELECTED MT1 AND MT2 MELATONIN RECEPTOR LIGANDS: REQUIREMENTS FOR SUBTYPE SELECTIVITY AND INTRINSIC ACTIVITY MODULATION 192
Synthesis and conformational study of 3,4-carbocyclic bridged indole melatonin and serotonin analogues 192
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice 191
Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors 191
Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study. 190
STRUCTURE-AFFINITY RELATIONSHIPS OF INDOLE-BASED MELATONIN ANALOGS 188
Strategies leading to MT2 selective melatonin receptor antagonists 187
2-5-Disubstituted tryptamines a selective serotonin 5HT6 receptor agonists. 185
Recent advances in the development of melatonin MT1 and MT2 receptor agonists 182
Progettazione e Sintesi di nuovi ligandi dei recettori MT1 e MT2 della melatonina a struttura difenilalchilammidica. 182
Reactions of 3-Carbomethoxy-2-aza-1,3-Butadiene Derivatives with Dienophiles 181
Derivati 2-Acilamminoalchilindolici come Antagonisti/Agonisti Parziali della Melatonina 181
Melatonin receptor agonists: new options for insomnia and depression treatment 181
Melatonin, non-selective MT1/MT2 and selective MT2 receptor agonists: differential effects on the 24-hr vigilance states 181
Description of the constitutive activity of cloned human melatonin receptors hMT1 and hMT2 and discovery of inverse agonists 180
Strategies leading to MT2 selective melatonin receptor antagonists 179
Totale 28.138
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Categoria #
all - tutte 126.013
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 126.013
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.285 0 0 0 250 33 49 74 114 118 106 46 495
2022/20232.759 309 175 73 333 234 605 12 231 449 92 177 69
2023/2024787 58 69 32 99 55 133 47 56 85 63 23 67
2024/20253.678 188 149 636 156 107 225 405 149 249 230 359 825
2025/20269.693 656 875 1.376 1.126 590 534 948 253 2.275 551 364 145
2026/20271.774 318 213 673 570 0 0 0 0 0 0 0 0
Totale 37.355