IRIS
SPADONI, GILBERTO
 Distribuzione geografica
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Continente #
NA - Nord America 16.723
EU - Europa 11.541
AS - Asia 5.731
SA - Sud America 490
AF - Africa 110
Continente sconosciuto - Info sul continente non disponibili 24
OC - Oceania 23
AN - Antartide 1
Totale 34.643
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Nazione #
US - Stati Uniti d'America 16.527
GB - Regno Unito 2.995
CN - Cina 2.933
NL - Olanda 2.011
IT - Italia 1.589
SG - Singapore 1.516
UA - Ucraina 1.307
SE - Svezia 784
RU - Federazione Russa 740
FI - Finlandia 604
DE - Germania 587
TR - Turchia 522
BR - Brasile 372
FR - Francia 315
IE - Irlanda 268
VN - Vietnam 241
CA - Canada 136
IN - India 126
PL - Polonia 62
BE - Belgio 56
HK - Hong Kong 51
JP - Giappone 51
KR - Corea 50
AR - Argentina 48
ES - Italia 46
MX - Messico 39
BD - Bangladesh 38
AT - Austria 26
IQ - Iraq 26
ZA - Sudafrica 24
EG - Egitto 23
ID - Indonesia 23
KE - Kenya 21
RO - Romania 21
EU - Europa 20
PK - Pakistan 20
AU - Australia 16
PE - Perù 14
AE - Emirati Arabi Uniti 13
CO - Colombia 13
LT - Lituania 13
PT - Portogallo 13
CH - Svizzera 12
IR - Iran 12
SA - Arabia Saudita 12
AL - Albania 11
CL - Cile 10
IL - Israele 10
MA - Marocco 10
DK - Danimarca 9
KZ - Kazakistan 9
TG - Togo 9
UZ - Uzbekistan 9
VE - Venezuela 9
NP - Nepal 8
EC - Ecuador 7
EE - Estonia 7
HR - Croazia 7
JO - Giordania 7
KG - Kirghizistan 7
PH - Filippine 7
PY - Paraguay 7
BG - Bulgaria 6
CZ - Repubblica Ceca 6
MY - Malesia 6
GR - Grecia 5
IS - Islanda 5
JM - Giamaica 5
MD - Moldavia 5
SK - Slovacchia (Repubblica Slovacca) 5
TN - Tunisia 5
TW - Taiwan 5
A2 - ???statistics.table.value.countryCode.A2??? 4
AM - Armenia 4
AZ - Azerbaigian 4
BO - Bolivia 4
BY - Bielorussia 4
LA - Repubblica Popolare Democratica del Laos 4
LV - Lettonia 4
NZ - Nuova Zelanda 4
RS - Serbia 4
SI - Slovenia 4
AO - Angola 3
CR - Costa Rica 3
HU - Ungheria 3
OM - Oman 3
PA - Panama 3
SY - Repubblica araba siriana 3
UY - Uruguay 3
BZ - Belize 2
CI - Costa d'Avorio 2
DO - Repubblica Dominicana 2
DZ - Algeria 2
ET - Etiopia 2
GE - Georgia 2
GU - Guam 2
HN - Honduras 2
LB - Libano 2
LK - Sri Lanka 2
LU - Lussemburgo 2
Totale 34.615
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Città #
Southend 2.686
Amsterdam 1.952
Woodbridge 1.583
Fairfield 1.428
Ashburn 1.366
Dallas 1.328
Houston 1.165
Ann Arbor 1.087
Jacksonville 1.013
Chandler 899
Singapore 786
San Jose 669
Cambridge 648
Seattle 602
Wilmington 595
Nanjing 522
Beijing 442
Izmir 360
Urbino 320
Boardman 273
Helsinki 267
Dublin 265
Los Angeles 222
Nanchang 216
New York 207
Chicago 174
San Mateo 166
Princeton 157
Lauterbourg 156
Shenyang 127
Munich 119
Tianjin 110
Düsseldorf 109
Hebei 108
Changsha 107
Des Moines 93
Istanbul 91
Jiaxing 85
Ho Chi Minh City 81
Council Bluffs 72
Salt Lake City 71
Moscow 68
Santa Clara 66
Kunming 60
Velikiy Novgorod 59
Brussels 55
Jinan 54
Hanoi 53
Orem 53
Bremen 52
Shanghai 52
Toronto 52
Turku 52
São Paulo 49
San Diego 47
Buffalo 46
Warsaw 45
Rome 43
San Francisco 43
Seongnam 43
Frankfurt am Main 42
Guangzhou 42
London 42
Hong Kong 41
Elk Grove Village 40
Nuremberg 40
Hangzhou 39
Montreal 37
Tampa 37
Zhengzhou 37
Mülheim 36
Tokyo 36
Venice 35
Milan 34
Stockholm 34
Chennai 31
Changchun 30
Ningbo 27
Phoenix 26
Denver 25
Haikou 25
Poplar 25
Wuppertal 23
Manchester 21
Bologna 20
Dong Ket 20
The Dalles 20
Atlanta 19
Bellaria-Igea Marina 19
Brooklyn 19
Johannesburg 19
Sterling 19
Augusta 18
Dulles 18
Lanzhou 18
Mexico City 18
Monte Porzio 18
Auburn Hills 17
Lancaster 17
Parma 17
Totale 24.820
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Nome #
1-(2-Alkylamidoethyl)-6-methoxyindole Derivatives: A New Class of Potent Indole Melatonin Analogues. 3.179
Industrial and academic approaches to the search for alternative melatonin receptor ligands: An historical survey. 704
Derivatizzazione one-pot di indoli per la sintesi di triptofani, pirroloindoline, bis-indoli & co 445
1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID DERIVATIVES AS LIGANDS AT THE GLYCINE-BINDING SITE OF THE N-METHYL-D-ASPARTATE RECEPTOR 429
Iridium-Catalyzed Direct Synthesis of Tryptamine Derivatives from Indoles: Exploiting N-Protected β-Amino Alcohols as Alkylating Agents 389
1-Aminocyclopropane-1-carboxylic acid derivatives: Synthesis and NMDA receptor complex binding affinity study. 328
1-Amminocyclopropane-1-Carboxylic Acid Derivatives: A New, General Synthesis and NMDA Receptor Complex Binding Affiniy Study 326
Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012-2014) 321
An improved synthesis of cis-4-phenyl-2-propionamidotetralin (4-P-PDOT): a selective MT2 melatonin receptor antagonist. 320
A Novel One-Pot Approach of Hexahydropyrrolo[2,3-b]indole Nucleus by a cascade addition/cyclization strategy: Synthesis of (±)-Esermethole 304
Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties 302
Synthesis and Configuration Determination of All Enantiopure Stereoisomers of the Melatonin Receptor Ligand 4-Phenyl-2-propionamidotetralin using an Expedient Optical Resolution of 4-Phenyl-2-tetralone 299
Synthesis of Tryptamine Derivatives via a Direct, One-Pot Reductive Alkylation of Indoles 296
Design, synthesis and biological activity of hydrogen peroxide responsive arylboronate melatonin hybrids 294
Synthesis of 2-substituted tryptophans via a C3- to C2-alkyl migration 286
A New Synthesis of 2-Substituted DL-Tryptophan Derivatives 285
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis, Binding Affinity for Melatonin Receptor, and Evaluation of the Biological Activity 281
(E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists. 275
3-(2-Carbamoylvinyl)-4,5-dimethylpyrrole-2-carboxylic acids as ligands at the NMDA glycine-binding site: a study on the 2-carbamoylvinyl chain modification 274
Synthesis and Characterization of New Bivalent Agents as Melatonin- and Histamine H3-Ligands 274
Synthesis and Biological Activity of new melatonin dimeric derivatives. 272
A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties 272
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 271
Tricyclic Alkylamides as Melatonin Receptor Ligands with Antagonist or Inverse Agonist Activity 270
Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines 270
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands 270
4,5-Dihydroisoxazole and 4,5-dihydro-1,2,4-oxadiazole derivatives from cycloaddition reactions of nitrile oxides to alkyl N-(diphenylmethylene)-α ,β -dehydroamino acids 268
Analogues of benzamide as poly(ADP-ribose)transferase inhibitors: a study on structure activity relationships. 265
Alkyl 2 (Diphenyl-methyleneamino) acrylates in the Synthesis of α-Amino Acids 265
Direct, One-Pot Reductive Alkylation of Anilines with Functionalized Acetals Mediated by Triethylsilane and TFA. Straightforward Route for Unsymmetrically Substituted Ethylenediamine 264
Selective Melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways 261
Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit 257
Organocatalyzed coupling of indoles with dehydroalanine esters: synthesis of bis(indolyl)propanoates and indolacrylates 254
Reassessing the melatonin pharmacophore: enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue. 251
2-Bromomelatonin: Synthesis and characterization of a potent melatonin agonist 243
2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists 240
Brønsted Acid-Catalyzed Bisindolization of α-amido acetals: Synthesis and Anticancer activity of bis(indolyl)ethanamino derivatives 237
N (Diphenylmethylene)-α,β−didehydroamino Acid Esters. Thermal and Lewis Acid Induced Dimerizations 234
POSITIVE ION-MASS SPECTRA AND COLLISION-INDUCED DISSOCIATION OF SOME 2,3-DIDEHYDRO AMINO ACIDS 231
2,3-Dehydroamino acid derivatives as intermediates in the synthesis of heterocyclic compounds. 227
Reaction of Secondary Acetylenic Bromides with Sodium Nitrite: Synthesis of 3,5-Alkyl(aryl)-4-nitroisoxazoles 225
2-Arylmelatonin analogues: Probing the 2-phenyl binding pocket of melatonin MT1 and MT2 receptors 224
The rationale for the development of melatonin receptor ligands 223
5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors, preparation, and therapeutic use.. 223
Diastereo- and enantioselective hydrogenation of a challenging enamide derived from 4-phenyl-2-tetralone: an appealing shortcut towards enantiopure cis-2-aminotetraline derivatives 223
Conformation by NMR of two tetralin-based receptor ligands 221
N-(Substituted-anilinoethyl)acylamides: Design, Synthesis and Pharmacological Characterization of a New Class of Melatonin Receptor Ligands 221
(E)-3-[2-(Carbamoylvinyl)]pyrrol-2-carboxylic acid derivatives: A novel Class of glycine site Antagonists. 219
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands. 219
Structural requirements for inhibitors of poly(ADP-ribose) polymerase. 218
Design and synthesis of N-[3,3-diphenyl-propenyl]alkanamides as a novel class of potent MT2-selective Melatonin receptor ligands 218
Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle 218
Bivalent Ligand Approach on N-[2-[(3-methoxyphenyl)methylamino]ethyl]acetamide. Synthesis, Binding Affinity and Intrinsic Acivity for MT(1) and MT(2) melatonin Receptors. 217
Toward the Definition of Stereochemical Requirements for MT(2)-Selective Antagonists and Partial Agonists by Studying 4-Phenyl-2-propionamidotetralin Derivatives 217
Pharmacokinetic and pharmacodynamic evaluation of ramelteon : an insomnia therapy 216
Synthetic Melatonin Receptor Ligands 215
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 214
N-(DIPHENYLMETHYLENE)-ALPHA,BETA-DIDEHYDROAMINO ACID ESTERS. THERMAL AND LEWIS ACID INDUCED DIMERIZATIONS 212
Synthesis and Structure–Activity Relationships of a Series of Pyrrole Cannabinoid Receptor Agonists 211
N-acetiltriptamine 2,5-sostituite: sintesi e valutazione dell’attività biologica per i recettori melatoninergici MT1 e MT2 211
Conformationally Restrained Melatonin Analogs: Synthesis, Binding Affinity for the Melatonin Receptor, Evaluation of the Biological Activity, and Molecular Modeling Study 211
Differentiation between isomeric 1-aminocyclopropane-1-carboxylic acid derivatives by means of chemical ionisation and mass selected collision induced dissociation 210
N-Acyl-5- and -2,5-substituted tryptamines: synthesis, activity and affinity for human mt1 and MT2 melatonin receptors 208
Substituted Benzamides as Poly(ADP-Ribose) transferase Inhibitors: Development of new Derivatives by using Computer Graphics Techniques 207
Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand 207
New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an in Vivo BRET-Based Discovery Platform 207
2-N-Acylaminoalkylindoles: Design and Quantitative Structure-Activity Relationship Studies Leading to MT2-Selective Antagonists. 206
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis and Binding Affinity to the Melatonin Receptor 206
Synthesis, Enantiomeric Resolution and Structure-Activity Relationship Study for a Series of 10,11-Dihydro-5H-dibenzo[a,d]cycloheptene MT2 Receptor Antagonists. 205
Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells 205
A Versatile Biomimetic Approach to Diindolylmethane Derivatives as Potential Anticancer Agents 204
Homology models of melatonin receptors: challenges and recent advances 199
MELATONIN RECEPTOR AGONISTS: SAR AND APPLICATIONS TO THE TREATMENT OF SLEEP-WAKE DISORDERS 198
Alchilammidi tricicliche: legandi selettivi dei recettori melatoninergici MT1 e MT2 198
ANALOGUES OF BENZAMIDE CONTAINING A SULPHUR ATOM AS POLY(ADP-ribose)TRANSFERASE INHIBITORS. 196
SYNTHESIS, BINDING AFFINITY FOR THE MELATONIN RECEPTOR, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF NEW INDOLE-BASED MELATONIN ANALOGUES. 196
Metastable ion studies in the characterization melatonin isomers 189
Substituent effects on 1,3-dipolar cycloadditions to some 1,1-diphenyl-2-aza-1,3-butadiene derivatives 188
Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors 188
A novel melatonin partial agonist with sleep-promoting properties 186
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice 184
The Hypnotic and Analgesic Effects of 2-Bromomelatonin 183
THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON SELECTED MT1 AND MT2 MELATONIN RECEPTOR LIGANDS: REQUIREMENTS FOR SUBTYPE SELECTIVITY AND INTRINSIC ACTIVITY MODULATION 183
Synthesis and conformational study of 3,4-carbocyclic bridged indole melatonin and serotonin analogues 183
Strategies leading to MT2 selective melatonin receptor antagonists 181
7-Substituted theophyllines. Part VI. N-[2-(4-Chlorophenoxy)-1-phenyl-alkyl]-alkylamido derivatives. 181
Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam 181
STRUCTURE-AFFINITY RELATIONSHIPS OF INDOLE-BASED MELATONIN ANALOGS 180
Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study. 179
Reactions of 3-Carbomethoxy-2-aza-1,3-Butadiene Derivatives with Dienophiles 177
2-5-Disubstituted tryptamines a selective serotonin 5HT6 receptor agonists. 176
Melatonin antagonizes apoptosis via receptor interaction in U937 monocytic cell 176
Recent advances in the development of melatonin MT1 and MT2 receptor agonists 175
Progettazione e Sintesi di nuovi ligandi dei recettori MT1 e MT2 della melatonina a struttura difenilalchilammidica. 174
Derivati 2-Acilamminoalchilindolici come Antagonisti/Agonisti Parziali della Melatonina 174
Strategies leading to MT2 selective melatonin receptor antagonists 173
Description of the constitutive activity of cloned human melatonin receptors hMT1 and hMT2 and discovery of inverse agonists 172
Melatonin receptor agonists: new options for insomnia and depression treatment 172
Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity 171
DESIGN AND SYNTHESIS OF MELATONIN RECEPTORS AGONISTS AND ANTAGONISTS 169
Totale 26.656
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Categoria #
all - tutte 112.686
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 112.686
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021851 0 0 0 0 0 0 0 0 0 310 363 178
2021/20221.844 170 196 193 250 33 49 74 114 118 106 46 495
2022/20232.759 309 175 73 333 234 605 12 231 449 92 177 69
2023/2024787 58 69 32 99 55 133 47 56 85 63 23 67
2024/20253.678 188 149 636 156 107 225 405 149 249 230 359 825
2025/20269.079 656 875 1.376 1.126 590 534 948 253 2.275 446 0 0
Totale 34.967