IRIS
SPADONI, GILBERTO
 Distribuzione geografica
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Continente #
NA - Nord America 17.572
EU - Europa 11.618
AS - Asia 5.875
SA - Sud America 500
Continente sconosciuto - Info sul continente non disponibili 350
AF - Africa 110
OC - Oceania 23
AN - Antartide 1
Totale 36.049
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Nazione #
US - Stati Uniti d'America 17.334
GB - Regno Unito 3.002
CN - Cina 2.986
NL - Olanda 2.014
IT - Italia 1.647
SG - Singapore 1.573
UA - Ucraina 1.307
SE - Svezia 785
RU - Federazione Russa 740
FI - Finlandia 604
DE - Germania 587
TR - Turchia 522
BR - Brasile 374
FR - Francia 315
IE - Irlanda 268
VN - Vietnam 243
CA - Canada 149
IN - India 126
HK - Hong Kong 66
PL - Polonia 63
BE - Belgio 56
JP - Giappone 55
AR - Argentina 51
KR - Corea 51
ES - Italia 48
BD - Bangladesh 46
MX - Messico 45
AT - Austria 26
IQ - Iraq 26
ZA - Sudafrica 24
EG - Egitto 23
ID - Indonesia 23
KE - Kenya 21
RO - Romania 21
EU - Europa 20
PK - Pakistan 20
AU - Australia 16
CO - Colombia 16
PT - Portogallo 15
PE - Perù 14
AE - Emirati Arabi Uniti 13
LT - Lituania 13
AL - Albania 12
CH - Svizzera 12
IR - Iran 12
SA - Arabia Saudita 12
CL - Cile 11
IL - Israele 10
JM - Giamaica 10
MA - Marocco 10
VE - Venezuela 10
CR - Costa Rica 9
DK - Danimarca 9
KZ - Kazakistan 9
MY - Malesia 9
TG - Togo 9
UZ - Uzbekistan 9
NP - Nepal 8
BG - Bulgaria 7
EC - Ecuador 7
EE - Estonia 7
HR - Croazia 7
JO - Giordania 7
KG - Kirghizistan 7
PH - Filippine 7
PY - Paraguay 7
CZ - Repubblica Ceca 6
HN - Honduras 6
GR - Grecia 5
IS - Islanda 5
MD - Moldavia 5
SK - Slovacchia (Repubblica Slovacca) 5
TN - Tunisia 5
TW - Taiwan 5
A2 - ???statistics.table.value.countryCode.A2??? 4
AM - Armenia 4
AZ - Azerbaigian 4
BO - Bolivia 4
BY - Bielorussia 4
HU - Ungheria 4
LA - Repubblica Popolare Democratica del Laos 4
LV - Lettonia 4
NZ - Nuova Zelanda 4
RS - Serbia 4
SI - Slovenia 4
AO - Angola 3
NI - Nicaragua 3
OM - Oman 3
PA - Panama 3
SY - Repubblica araba siriana 3
TH - Thailandia 3
UY - Uruguay 3
BZ - Belize 2
CI - Costa d'Avorio 2
DO - Repubblica Dominicana 2
DZ - Algeria 2
ET - Etiopia 2
GE - Georgia 2
GU - Guam 2
LB - Libano 2
Totale 35.688
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Città #
Southend 2.686
Amsterdam 1.952
Woodbridge 1.583
Fairfield 1.428
Ashburn 1.427
Dallas 1.346
Houston 1.170
Ann Arbor 1.091
Jacksonville 1.015
Chandler 899
Singapore 802
San Jose 787
Cambridge 648
Seattle 602
Wilmington 596
Nanjing 522
Beijing 462
Izmir 360
Boardman 344
Urbino 320
Helsinki 267
Dublin 265
Council Bluffs 236
Los Angeles 235
New York 222
Nanchang 216
Chicago 177
San Mateo 166
Princeton 157
Lauterbourg 156
Shenyang 127
Munich 119
Santa Clara 112
Tianjin 110
Changsha 109
Düsseldorf 109
Hebei 108
Des Moines 93
Istanbul 91
Jiaxing 85
Ho Chi Minh City 82
Salt Lake City 71
Moscow 68
Kunming 60
Velikiy Novgorod 59
Orem 57
Hong Kong 56
Brussels 55
Buffalo 55
Jinan 54
Shanghai 54
Hanoi 53
Toronto 53
Bremen 52
Turku 52
São Paulo 49
San Diego 47
San Francisco 47
London 46
Warsaw 45
Milan 44
Rome 44
Seongnam 43
Frankfurt am Main 42
Guangzhou 42
Hangzhou 42
Montreal 42
Elk Grove Village 40
Nuremberg 40
Tokyo 39
Tampa 37
Zhengzhou 37
Mülheim 36
Venice 36
Stockholm 34
Chennai 31
Changchun 30
Denver 30
Phoenix 30
Ningbo 27
Brooklyn 25
Haikou 25
Poplar 25
The Dalles 23
Wuppertal 23
Manchester 22
Mexico City 22
Atlanta 21
Bologna 20
Dong Ket 20
Augusta 19
Bellaria-Igea Marina 19
Johannesburg 19
Sterling 19
Boston 18
Dulles 18
Lancaster 18
Lanzhou 18
Monte Porzio 18
Auburn Hills 17
Totale 25.470
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Nome #
1-(2-Alkylamidoethyl)-6-methoxyindole Derivatives: A New Class of Potent Indole Melatonin Analogues. 3.197
Industrial and academic approaches to the search for alternative melatonin receptor ligands: An historical survey. 713
Derivatizzazione one-pot di indoli per la sintesi di triptofani, pirroloindoline, bis-indoli & co 487
1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID DERIVATIVES AS LIGANDS AT THE GLYCINE-BINDING SITE OF THE N-METHYL-D-ASPARTATE RECEPTOR 435
Iridium-Catalyzed Direct Synthesis of Tryptamine Derivatives from Indoles: Exploiting N-Protected β-Amino Alcohols as Alkylating Agents 398
Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012-2014) 359
1-Aminocyclopropane-1-carboxylic acid derivatives: Synthesis and NMDA receptor complex binding affinity study. 340
1-Amminocyclopropane-1-Carboxylic Acid Derivatives: A New, General Synthesis and NMDA Receptor Complex Binding Affiniy Study 332
An improved synthesis of cis-4-phenyl-2-propionamidotetralin (4-P-PDOT): a selective MT2 melatonin receptor antagonist. 330
Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties 312
A Novel One-Pot Approach of Hexahydropyrrolo[2,3-b]indole Nucleus by a cascade addition/cyclization strategy: Synthesis of (±)-Esermethole 311
Synthesis and Configuration Determination of All Enantiopure Stereoisomers of the Melatonin Receptor Ligand 4-Phenyl-2-propionamidotetralin using an Expedient Optical Resolution of 4-Phenyl-2-tetralone 304
Synthesis of Tryptamine Derivatives via a Direct, One-Pot Reductive Alkylation of Indoles 302
Design, synthesis and biological activity of hydrogen peroxide responsive arylboronate melatonin hybrids 301
A New Synthesis of 2-Substituted DL-Tryptophan Derivatives 290
Synthesis of 2-substituted tryptophans via a C3- to C2-alkyl migration 288
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis, Binding Affinity for Melatonin Receptor, and Evaluation of the Biological Activity 287
3-(2-Carbamoylvinyl)-4,5-dimethylpyrrole-2-carboxylic acids as ligands at the NMDA glycine-binding site: a study on the 2-carbamoylvinyl chain modification 287
(E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists. 283
Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines 280
A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties 279
Tricyclic Alkylamides as Melatonin Receptor Ligands with Antagonist or Inverse Agonist Activity 278
Synthesis and Characterization of New Bivalent Agents as Melatonin- and Histamine H3-Ligands 278
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 277
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands 275
Synthesis and Biological Activity of new melatonin dimeric derivatives. 274
4,5-Dihydroisoxazole and 4,5-dihydro-1,2,4-oxadiazole derivatives from cycloaddition reactions of nitrile oxides to alkyl N-(diphenylmethylene)-α ,β -dehydroamino acids 273
Selective Melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways 273
Alkyl 2 (Diphenyl-methyleneamino) acrylates in the Synthesis of α-Amino Acids 270
Analogues of benzamide as poly(ADP-ribose)transferase inhibitors: a study on structure activity relationships. 269
Direct, One-Pot Reductive Alkylation of Anilines with Functionalized Acetals Mediated by Triethylsilane and TFA. Straightforward Route for Unsymmetrically Substituted Ethylenediamine 269
Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit 262
Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle 262
Organocatalyzed coupling of indoles with dehydroalanine esters: synthesis of bis(indolyl)propanoates and indolacrylates 259
Reassessing the melatonin pharmacophore: enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue. 254
2-Bromomelatonin: Synthesis and characterization of a potent melatonin agonist 251
2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists 247
2-Arylmelatonin analogues: Probing the 2-phenyl binding pocket of melatonin MT1 and MT2 receptors 246
Brønsted Acid-Catalyzed Bisindolization of α-amido acetals: Synthesis and Anticancer activity of bis(indolyl)ethanamino derivatives 240
POSITIVE ION-MASS SPECTRA AND COLLISION-INDUCED DISSOCIATION OF SOME 2,3-DIDEHYDRO AMINO ACIDS 237
N (Diphenylmethylene)-α,β−didehydroamino Acid Esters. Thermal and Lewis Acid Induced Dimerizations 237
2,3-Dehydroamino acid derivatives as intermediates in the synthesis of heterocyclic compounds. 235
N-(Substituted-anilinoethyl)acylamides: Design, Synthesis and Pharmacological Characterization of a New Class of Melatonin Receptor Ligands 232
5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors, preparation, and therapeutic use.. 228
Conformation by NMR of two tetralin-based receptor ligands 226
The rationale for the development of melatonin receptor ligands 226
(E)-3-[2-(Carbamoylvinyl)]pyrrol-2-carboxylic acid derivatives: A novel Class of glycine site Antagonists. 226
Bivalent Ligand Approach on N-[2-[(3-methoxyphenyl)methylamino]ethyl]acetamide. Synthesis, Binding Affinity and Intrinsic Acivity for MT(1) and MT(2) melatonin Receptors. 226
Reaction of Secondary Acetylenic Bromides with Sodium Nitrite: Synthesis of 3,5-Alkyl(aryl)-4-nitroisoxazoles 225
Diastereo- and enantioselective hydrogenation of a challenging enamide derived from 4-phenyl-2-tetralone: an appealing shortcut towards enantiopure cis-2-aminotetraline derivatives 225
N-acetiltriptamine 2,5-sostituite: sintesi e valutazione dell’attività biologica per i recettori melatoninergici MT1 e MT2 223
Structural requirements for inhibitors of poly(ADP-ribose) polymerase. 222
Design and synthesis of N-[3,3-diphenyl-propenyl]alkanamides as a novel class of potent MT2-selective Melatonin receptor ligands 222
Synthetic Melatonin Receptor Ligands 221
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands. 220
New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an in Vivo BRET-Based Discovery Platform 220
Pharmacokinetic and pharmacodynamic evaluation of ramelteon : an insomnia therapy 219
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 219
N-(DIPHENYLMETHYLENE)-ALPHA,BETA-DIDEHYDROAMINO ACID ESTERS. THERMAL AND LEWIS ACID INDUCED DIMERIZATIONS 217
Toward the Definition of Stereochemical Requirements for MT(2)-Selective Antagonists and Partial Agonists by Studying 4-Phenyl-2-propionamidotetralin Derivatives 217
Differentiation between isomeric 1-aminocyclopropane-1-carboxylic acid derivatives by means of chemical ionisation and mass selected collision induced dissociation 216
Conformationally Restrained Melatonin Analogs: Synthesis, Binding Affinity for the Melatonin Receptor, Evaluation of the Biological Activity, and Molecular Modeling Study 216
Synthesis and Structure–Activity Relationships of a Series of Pyrrole Cannabinoid Receptor Agonists 215
MT1-Selective Melatonin Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Dynamics Investigation of N-{[(3-O-Substituted)anilino]alkyl}amides 215
N-Acyl-5- and -2,5-substituted tryptamines: synthesis, activity and affinity for human mt1 and MT2 melatonin receptors 214
Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand 214
Synthesis, Enantiomeric Resolution and Structure-Activity Relationship Study for a Series of 10,11-Dihydro-5H-dibenzo[a,d]cycloheptene MT2 Receptor Antagonists. 213
A Versatile Biomimetic Approach to Diindolylmethane Derivatives as Potential Anticancer Agents 213
2-N-Acylaminoalkylindoles: Design and Quantitative Structure-Activity Relationship Studies Leading to MT2-Selective Antagonists. 211
Substituted Benzamides as Poly(ADP-Ribose) transferase Inhibitors: Development of new Derivatives by using Computer Graphics Techniques 211
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis and Binding Affinity to the Melatonin Receptor 209
Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells 209
Homology models of melatonin receptors: challenges and recent advances 207
MELATONIN RECEPTOR AGONISTS: SAR AND APPLICATIONS TO THE TREATMENT OF SLEEP-WAKE DISORDERS 206
SYNTHESIS, BINDING AFFINITY FOR THE MELATONIN RECEPTOR, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF NEW INDOLE-BASED MELATONIN ANALOGUES. 206
Alchilammidi tricicliche: legandi selettivi dei recettori melatoninergici MT1 e MT2 205
ANALOGUES OF BENZAMIDE CONTAINING A SULPHUR ATOM AS POLY(ADP-ribose)TRANSFERASE INHIBITORS. 197
Metastable ion studies in the characterization melatonin isomers 194
Substituent effects on 1,3-dipolar cycloadditions to some 1,1-diphenyl-2-aza-1,3-butadiene derivatives 191
The Hypnotic and Analgesic Effects of 2-Bromomelatonin 190
Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam 190
A novel melatonin partial agonist with sleep-promoting properties 189
7-Substituted theophyllines. Part VI. N-[2-(4-Chlorophenoxy)-1-phenyl-alkyl]-alkylamido derivatives. 189
Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors 189
Melatonin antagonizes apoptosis via receptor interaction in U937 monocytic cell 189
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice 188
Synthesis and conformational study of 3,4-carbocyclic bridged indole melatonin and serotonin analogues 187
THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON SELECTED MT1 AND MT2 MELATONIN RECEPTOR LIGANDS: REQUIREMENTS FOR SUBTYPE SELECTIVITY AND INTRINSIC ACTIVITY MODULATION 186
Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study. 185
Strategies leading to MT2 selective melatonin receptor antagonists 184
STRUCTURE-AFFINITY RELATIONSHIPS OF INDOLE-BASED MELATONIN ANALOGS 183
Recent advances in the development of melatonin MT1 and MT2 receptor agonists 180
2-5-Disubstituted tryptamines a selective serotonin 5HT6 receptor agonists. 180
Reactions of 3-Carbomethoxy-2-aza-1,3-Butadiene Derivatives with Dienophiles 179
Derivati 2-Acilamminoalchilindolici come Antagonisti/Agonisti Parziali della Melatonina 179
Description of the constitutive activity of cloned human melatonin receptors hMT1 and hMT2 and discovery of inverse agonists 178
Strategies leading to MT2 selective melatonin receptor antagonists 177
Progettazione e Sintesi di nuovi ligandi dei recettori MT1 e MT2 della melatonina a struttura difenilalchilammidica. 177
Melatonin receptor agonists: new options for insomnia and depression treatment 175
Antioxidant and cytoprotective effect of indole derivatives related to melatonin 173
Totale 27.404
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Categoria #
all - tutte 120.385
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 120.385
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.674 0 196 193 250 33 49 74 114 118 106 46 495
2022/20232.759 309 175 73 333 234 605 12 231 449 92 177 69
2023/2024787 58 69 32 99 55 133 47 56 85 63 23 67
2024/20253.678 188 149 636 156 107 225 405 149 249 230 359 825
2025/20269.693 656 875 1.376 1.126 590 534 948 253 2.275 551 364 145
2026/2027468 318 150 0 0 0 0 0 0 0 0 0 0
Totale 36.049