IRIS
SPADONI, GILBERTO
 Distribuzione geografica
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Continente #
NA - Nord America 12.196
EU - Europa 8.439
AS - Asia 3.474
SA - Sud America 54
AF - Africa 40
Continente sconosciuto - Info sul continente non disponibili 24
OC - Oceania 20
AN - Antartide 1
Totale 24.248
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Nazione #
US - Stati Uniti d'America 12.114
GB - Regno Unito 2.915
CN - Cina 2.125
IT - Italia 1.426
UA - Ucraina 1.292
SE - Svezia 755
SG - Singapore 587
TR - Turchia 503
FI - Finlandia 478
RU - Federazione Russa 473
DE - Germania 429
IE - Irlanda 267
FR - Francia 115
CA - Canada 73
IN - India 66
NL - Olanda 62
BE - Belgio 54
KR - Corea 47
BR - Brasile 38
VN - Vietnam 28
AT - Austria 23
JP - Giappone 22
ES - Italia 21
PL - Polonia 21
EU - Europa 20
HK - Hong Kong 19
RO - Romania 18
AU - Australia 16
KE - Kenya 13
CH - Svizzera 11
EG - Egitto 10
TG - Togo 9
IL - Israele 8
IR - Iran 8
AL - Albania 7
DK - Danimarca 7
EE - Estonia 7
HR - Croazia 7
PK - Pakistan 7
ID - Indonesia 6
BG - Bulgaria 5
KG - Kirghizistan 5
LT - Lituania 5
MA - Marocco 5
PE - Perù 5
A2 - ???statistics.table.value.countryCode.A2??? 4
AM - Armenia 4
CZ - Repubblica Ceca 4
IQ - Iraq 4
IS - Islanda 4
KZ - Kazakistan 4
LA - Repubblica Popolare Democratica del Laos 4
RS - Serbia 4
SI - Slovenia 4
SK - Slovacchia (Repubblica Slovacca) 4
AR - Argentina 3
BD - Bangladesh 3
BO - Bolivia 3
GR - Grecia 3
HU - Ungheria 3
LV - Lettonia 3
MX - Messico 3
PA - Panama 3
PT - Portogallo 3
SA - Arabia Saudita 3
TW - Taiwan 3
AE - Emirati Arabi Uniti 2
AZ - Azerbaigian 2
BY - Bielorussia 2
BZ - Belize 2
CO - Colombia 2
GE - Georgia 2
GU - Guam 2
JO - Giordania 2
LB - Libano 2
LK - Sri Lanka 2
LU - Lussemburgo 2
MD - Moldavia 2
NZ - Nuova Zelanda 2
SM - San Marino 2
TH - Thailandia 2
CL - Cile 1
FK - Isole Falkland (Malvinas) 1
GS - Georgia del Sud e Isole Sandwich Australi 1
IM - Isola di Man 1
JM - Giamaica 1
KH - Cambogia 1
NP - Nepal 1
PH - Filippine 1
PY - Paraguay 1
SC - Seychelles 1
SL - Sierra Leone 1
UZ - Uzbekistan 1
ZA - Sudafrica 1
Totale 24.248
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Città #
Southend 2.686
Woodbridge 1.583
Fairfield 1.428
Houston 1.145
Ann Arbor 1.087
Jacksonville 1.012
Chandler 899
Ashburn 692
Cambridge 648
Seattle 592
Wilmington 577
Nanjing 521
Izmir 359
Urbino 318
Singapore 310
Boardman 273
Dublin 265
Nanchang 215
Helsinki 195
San Mateo 166
Beijing 158
Princeton 157
Shenyang 127
New York 111
Hebei 108
Changsha 103
Tianjin 103
Des Moines 93
Düsseldorf 92
Istanbul 88
Jiaxing 85
Moscow 65
Kunming 60
Velikiy Novgorod 59
Jinan 54
Brussels 53
Bremen 52
San Diego 46
Shanghai 45
Toronto 44
Seongnam 43
Santa Clara 40
Mülheim 36
Zhengzhou 35
Venice 34
Guangzhou 33
Hangzhou 33
Milan 33
Rome 33
Nuremberg 31
Los Angeles 30
San Francisco 30
London 29
Amsterdam 27
Changchun 27
Ningbo 27
Haikou 25
Wuppertal 23
Munich 21
Bologna 20
Dong Ket 20
Lanzhou 18
Monte Porzio 18
Auburn Hills 17
Parma 17
Dearborn 16
Norwalk 16
Augusta 15
Ancona 14
Osimo 14
Redwood City 14
Frankfurt am Main 13
Shenzhen 13
Taizhou 13
Tavullia 13
Leawood 11
Naples 11
Portland 11
Hong Kong 10
Mcallen 10
North Bergen 10
Pesaro 10
Ascoli Piceno 9
Borås 9
Fuzhou 9
Lomé 9
Nairobi 9
Rimini 9
Taranto 9
Vienna 9
Casalecchio di Reno 8
Orange 8
Orciano Di Pesaro 8
Ottawa 8
Scottsdale 8
São Paulo 8
Tokyo 8
West Jordan 8
Acquasanta Terme 7
Angri 7
Totale 17.738
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Nome #
1-(2-Alkylamidoethyl)-6-methoxyindole Derivatives: A New Class of Potent Indole Melatonin Analogues. 353
1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID DERIVATIVES AS LIGANDS AT THE GLYCINE-BINDING SITE OF THE N-METHYL-D-ASPARTATE RECEPTOR 344
Iridium-Catalyzed Direct Synthesis of Tryptamine Derivatives from Indoles: Exploiting N-Protected β-Amino Alcohols as Alkylating Agents 329
1-Aminocyclopropane-1-carboxylic acid derivatives: Synthesis and NMDA receptor complex binding affinity study. 269
Derivatizzazione one-pot di indoli per la sintesi di triptofani, pirroloindoline, bis-indoli & co 267
Synthesis of Tryptamine Derivatives via a Direct, One-Pot Reductive Alkylation of Indoles 259
Synthesis of 2-substituted tryptophans via a C3- to C2-alkyl migration 252
Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties 249
An improved synthesis of cis-4-phenyl-2-propionamidotetralin (4-P-PDOT): a selective MT2 melatonin receptor antagonist. 247
1-Amminocyclopropane-1-Carboxylic Acid Derivatives: A New, General Synthesis and NMDA Receptor Complex Binding Affiniy Study 247
Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012-2014) 245
Synthesis and Configuration Determination of All Enantiopure Stereoisomers of the Melatonin Receptor Ligand 4-Phenyl-2-propionamidotetralin using an Expedient Optical Resolution of 4-Phenyl-2-tetralone 237
Tricyclic Alkylamides as Melatonin Receptor Ligands with Antagonist or Inverse Agonist Activity 236
Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats 234
Organocatalyzed coupling of indoles with dehydroalanine esters: synthesis of bis(indolyl)propanoates and indolacrylates 230
Synthesis and Characterization of New Bivalent Agents as Melatonin- and Histamine H3-Ligands 229
A Novel One-Pot Approach of Hexahydropyrrolo[2,3-b]indole Nucleus by a cascade addition/cyclization strategy: Synthesis of (±)-Esermethole 228
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis, Binding Affinity for Melatonin Receptor, and Evaluation of the Biological Activity 225
Direct, One-Pot Reductive Alkylation of Anilines with Functionalized Acetals Mediated by Triethylsilane and TFA. Straightforward Route for Unsymmetrically Substituted Ethylenediamine 224
A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties 224
A New Synthesis of 2-Substituted DL-Tryptophan Derivatives 222
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands 221
Alkyl 2 (Diphenyl-methyleneamino) acrylates in the Synthesis of α-Amino Acids 219
(E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists. 216
Analogues of benzamide as poly(ADP-ribose)transferase inhibitors: a study on structure activity relationships. 215
Design, synthesis and biological activity of hydrogen peroxide responsive arylboronate melatonin hybrids 215
Synthesis and Biological Activity of new melatonin dimeric derivatives. 211
4,5-Dihydroisoxazole and 4,5-dihydro-1,2,4-oxadiazole derivatives from cycloaddition reactions of nitrile oxides to alkyl N-(diphenylmethylene)-α ,β -dehydroamino acids 208
POSITIVE ION-MASS SPECTRA AND COLLISION-INDUCED DISSOCIATION OF SOME 2,3-DIDEHYDRO AMINO ACIDS 206
3-(2-Carbamoylvinyl)-4,5-dimethylpyrrole-2-carboxylic acids as ligands at the NMDA glycine-binding site: a study on the 2-carbamoylvinyl chain modification 205
Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines 203
Synthetic Melatonin Receptor Ligands 192
Toward the Definition of Stereochemical Requirements for MT(2)-Selective Antagonists and Partial Agonists by Studying 4-Phenyl-2-propionamidotetralin Derivatives 192
2-Bromomelatonin: Synthesis and characterization of a potent melatonin agonist 191
Structural requirements for inhibitors of poly(ADP-ribose) polymerase. 190
The rationale for the development of melatonin receptor ligands 190
Substituted Benzamides as Poly(ADP-Ribose) transferase Inhibitors: Development of new Derivatives by using Computer Graphics Techniques 190
Reaction of Secondary Acetylenic Bromides with Sodium Nitrite: Synthesis of 3,5-Alkyl(aryl)-4-nitroisoxazoles 190
N (Diphenylmethylene)-α,β−didehydroamino Acid Esters. Thermal and Lewis Acid Induced Dimerizations 189
Synthesis and Structure–Activity Relationships of a Series of Pyrrole Cannabinoid Receptor Agonists 188
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands. 188
Conformation by NMR of two tetralin-based receptor ligands 186
Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit 184
Differentiation between isomeric 1-aminocyclopropane-1-carboxylic acid derivatives by means of chemical ionisation and mass selected collision induced dissociation 183
Pharmacokinetic and pharmacodynamic evaluation of ramelteon : an insomnia therapy 183
Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety 182
Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand 181
Brønsted Acid-Catalyzed Bisindolization of α-amido acetals: Synthesis and Anticancer activity of bis(indolyl)ethanamino derivatives 178
5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors, preparation, and therapeutic use.. 177
Selective Melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways 176
Diastereo- and enantioselective hydrogenation of a challenging enamide derived from 4-phenyl-2-tetralone: an appealing shortcut towards enantiopure cis-2-aminotetraline derivatives 175
New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an in Vivo BRET-Based Discovery Platform 175
Substituent effects on 1,3-dipolar cycloadditions to some 1,1-diphenyl-2-aza-1,3-butadiene derivatives 174
MELATONIN RECEPTOR AGONISTS: SAR AND APPLICATIONS TO THE TREATMENT OF SLEEP-WAKE DISORDERS 173
Synthesis, Enantiomeric Resolution and Structure-Activity Relationship Study for a Series of 10,11-Dihydro-5H-dibenzo[a,d]cycloheptene MT2 Receptor Antagonists. 173
Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle 173
2,3-Dehydroamino acid derivatives as intermediates in the synthesis of heterocyclic compounds. 172
Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors 171
Design and synthesis of N-[3,3-diphenyl-propenyl]alkanamides as a novel class of potent MT2-selective Melatonin receptor ligands 169
Reassessing the melatonin pharmacophore: enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue. 169
N-(DIPHENYLMETHYLENE)-ALPHA,BETA-DIDEHYDROAMINO ACID ESTERS. THERMAL AND LEWIS ACID INDUCED DIMERIZATIONS 167
Conformationally Restrained Melatonin Analogs: Synthesis, Binding Affinity for the Melatonin Receptor, Evaluation of the Biological Activity, and Molecular Modeling Study 166
2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists 166
N-(Substituted-anilinoethyl)acylamides: Design, Synthesis and Pharmacological Characterization of a New Class of Melatonin Receptor Ligands 165
Bivalent Ligand Approach on N-[2-[(3-methoxyphenyl)methylamino]ethyl]acetamide. Synthesis, Binding Affinity and Intrinsic Acivity for MT(1) and MT(2) melatonin Receptors. 165
The Hypnotic and Analgesic Effects of 2-Bromomelatonin 163
Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells 163
N-Acyl-5- and -2,5-substituted tryptamines: synthesis, activity and affinity for human mt1 and MT2 melatonin receptors 161
Metastable ion studies in the characterization melatonin isomers 160
STRUCTURE-AFFINITY RELATIONSHIPS OF INDOLE-BASED MELATONIN ANALOGS 160
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice 158
Recent advances in the development of melatonin MT1 and MT2 receptor agonists 157
N-acetiltriptamine 2,5-sostituite: sintesi e valutazione dell’attività biologica per i recettori melatoninergici MT1 e MT2 156
Description of the constitutive activity of cloned human melatonin receptors hMT1 and hMT2 and discovery of inverse agonists 156
Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam 156
Derivati 2-Acilamminoalchilindolici come Antagonisti/Agonisti Parziali della Melatonina 155
Alchilammidi tricicliche: legandi selettivi dei recettori melatoninergici MT1 e MT2 155
Synthesis and conformational study of 3,4-carbocyclic bridged indole melatonin and serotonin analogues 155
(E)-3-[2-(Carbamoylvinyl)]pyrrol-2-carboxylic acid derivatives: A novel Class of glycine site Antagonists. 154
Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study. 154
THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON SELECTED MT1 AND MT2 MELATONIN RECEPTOR LIGANDS: REQUIREMENTS FOR SUBTYPE SELECTIVITY AND INTRINSIC ACTIVITY MODULATION 153
Homology models of melatonin receptors: challenges and recent advances 153
Reactions of 3-Carbomethoxy-2-aza-1,3-Butadiene Derivatives with Dienophiles 152
Strategies leading to MT2 selective melatonin receptor antagonists 151
Melatonin receptor agonists: new options for insomnia and depression treatment 150
Strategies leading to MT2 selective melatonin receptor antagonists 149
SYNTHESIS, BINDING AFFINITY FOR THE MELATONIN RECEPTOR, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF NEW INDOLE-BASED MELATONIN ANALOGUES. 149
Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models 149
Progettazione e Sintesi di nuovi ligandi dei recettori MT1 e MT2 della melatonina a struttura difenilalchilammidica. 145
2-Substituted-5-Methoxy-N-acyltryptamines: Synthesis and Binding Affinity to the Melatonin Receptor 143
ANALOGUES OF BENZAMIDE CONTAINING A SULPHUR ATOM AS POLY(ADP-ribose)TRANSFERASE INHIBITORS. 142
Short synthesis of tryptophan and β -carboline derivatives by reaction of indoles with N-(diphenylmethylene)-α ,β -didehydroamino acid esters 142
DESIGN AND SYNTHESIS OF MELATONIN RECEPTORS AGONISTS AND ANTAGONISTS 140
Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity 140
Stereospecific Synthesis of N- (Diphenylmethylene)-α,β-didehydroamino Acid Methyl Esters from β-Hydroxy-α-amino Acids 139
A Versatile Biomimetic Approach to Diindolylmethane Derivatives as Potential Anticancer Agents 137
2-N-Acylaminoalkylindoles: Design and Quantitative Structure-Activity Relationship Studies Leading to MT2-Selective Antagonists. 136
7-Substituted theophyllines. Part VI. N-[2-(4-Chlorophenoxy)-1-phenyl-alkyl]-alkylamido derivatives. 134
Melatonin, non-selective MT1/MT2 and selective MT2 receptor agonists: differential effects on the 24-hr vigilance states 134
Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities 133
Totale 18.786
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Categoria #
all - tutte 88.481
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 88.481
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020609 0 0 0 0 0 0 0 0 0 307 125 177
2020/20212.895 90 194 136 354 164 191 226 244 445 310 363 178
2021/20221.844 170 196 193 250 33 49 74 114 118 106 46 495
2022/20232.759 309 175 73 333 234 605 12 231 449 92 177 69
2023/2024787 58 69 32 99 55 133 47 56 85 63 23 67
2024/20252.361 188 149 636 156 107 225 405 149 249 97 0 0
Totale 24.571