IRIS
GUIDARELLI, ANDREA
 Distribuzione geografica
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Continente #
NA - Nord America 10.771
EU - Europa 6.335
AS - Asia 3.645
SA - Sud America 368
AF - Africa 60
Continente sconosciuto - Info sul continente non disponibili 14
OC - Oceania 10
Totale 21.203
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Nazione #
US - Stati Uniti d'America 10.620
GB - Regno Unito 1.824
CN - Cina 1.651
SG - Singapore 1.196
IT - Italia 954
UA - Ucraina 753
DE - Germania 703
RU - Federazione Russa 540
FI - Finlandia 502
SE - Svezia 500
BR - Brasile 289
TR - Turchia 272
FR - Francia 164
VN - Vietnam 157
IE - Irlanda 149
CA - Canada 88
PL - Polonia 77
BD - Bangladesh 61
IN - India 61
MX - Messico 49
KR - Corea 47
HK - Hong Kong 45
JP - Giappone 36
AR - Argentina 31
NL - Olanda 29
MA - Marocco 25
ES - Italia 24
ZA - Sudafrica 20
BE - Belgio 19
IQ - Iraq 15
LT - Lituania 15
ID - Indonesia 14
EU - Europa 13
CO - Colombia 12
PK - Pakistan 11
AU - Australia 9
CL - Cile 9
IR - Iran 9
SM - San Marino 9
AE - Emirati Arabi Uniti 8
EC - Ecuador 8
GR - Grecia 8
IL - Israele 8
VE - Venezuela 8
AT - Austria 7
PH - Filippine 6
PT - Portogallo 6
RO - Romania 6
UZ - Uzbekistan 6
BG - Bulgaria 5
CZ - Repubblica Ceca 5
JO - Giordania 5
KG - Kirghizistan 5
MD - Moldavia 5
PA - Panama 5
SA - Arabia Saudita 5
CH - Svizzera 4
CR - Costa Rica 4
HU - Ungheria 4
LV - Lettonia 4
PY - Paraguay 4
TH - Thailandia 4
UY - Uruguay 4
BO - Bolivia 3
DZ - Algeria 3
KW - Kuwait 3
LB - Libano 3
LU - Lussemburgo 3
MY - Malesia 3
NO - Norvegia 3
TW - Taiwan 3
DK - Danimarca 2
EE - Estonia 2
EG - Egitto 2
JM - Giamaica 2
SK - Slovacchia (Repubblica Slovacca) 2
SN - Senegal 2
TG - Togo 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AF - Afghanistan, Repubblica islamica di 1
AL - Albania 1
AZ - Azerbaigian 1
BT - Bhutan 1
BY - Bielorussia 1
CG - Congo 1
ET - Etiopia 1
GE - Georgia 1
HN - Honduras 1
HR - Croazia 1
IM - Isola di Man 1
IS - Islanda 1
KE - Kenya 1
KH - Cambogia 1
KY - Cayman, isole 1
LK - Sri Lanka 1
LY - Libia 1
ME - Montenegro 1
MM - Myanmar 1
NP - Nepal 1
NZ - Nuova Zelanda 1
Totale 21.196
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Città #
Southend 1.555
Woodbridge 1.278
Fairfield 1.122
Houston 988
Ashburn 973
Ann Arbor 718
Jacksonville 600
Singapore 575
Seattle 454
Chandler 452
Wilmington 448
Cambridge 437
San Jose 430
Munich 344
Helsinki 315
Dallas 302
Urbino 296
Nanjing 286
Beijing 248
Izmir 197
Boardman 191
New York 158
Dublin 149
Los Angeles 119
Lauterbourg 95
Princeton 93
Nanchang 91
Council Bluffs 78
Bremen 77
San Mateo 73
Shenyang 59
Chicago 56
Tianjin 56
Düsseldorf 53
Moscow 53
San Diego 53
Changsha 49
Hebei 46
Ho Chi Minh City 44
London 44
Hong Kong 43
Santa Clara 43
São Paulo 43
Columbus 42
Istanbul 39
Kraków 38
Seongnam 38
Toronto 38
Shanghai 37
Mülheim 35
San Francisco 35
Buffalo 34
Hanoi 34
Kunming 34
Orem 34
Frankfurt am Main 31
Guangzhou 29
Jiaxing 28
Velikiy Novgorod 25
Warsaw 25
Montreal 24
Tokyo 24
Atlanta 23
Mexico City 23
Hangzhou 22
Denver 21
Jinan 21
Rome 21
The Dalles 21
Brooklyn 19
Brussels 19
Milan 19
Salt Lake City 19
Casablanca 18
Lanzhou 18
Stockholm 18
Chennai 17
Turku 17
Des Moines 16
Dong Ket 16
Ningbo 16
Venice 16
Falls Church 15
Johannesburg 15
Pesaro 15
Amsterdam 14
Ancona 14
Shenzhen 13
Tampa 13
Wuppertal 12
Changchun 11
Haikou 11
Manchester 11
Rimini 11
Rio de Janeiro 11
Zhengzhou 11
Acton 10
Ankara 10
Bellaria-Igea Marina 10
Civitanova Marche 10
Totale 15.005
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Nome #
Intracellular dehydroascorbic acid inhibits SVCT2-dependent transport of ascorbic acid in mitochondria 431
Superoxide dictates the mode of U937 cell ascorbic acid uptake and prevents the enhancing effects of the vitamin to otherwise non-toxic levels of reactive oxygen/nitrogen species 421
Mitochondrial ascorbic acid prevents mitochondrial O2.- formation, an event critical for U937 cell apoptosis induced by arsenite through both autophagic-dependent and independent mechanisms 385
U937 cell apoptosis induced by arsenite is prevented by low concentrations of mitochondrial ascorbic acid with hardly any effect mediated by the cytosolic fraction of the vitamin 325
A novel mechanism, uniquely dependent on mitochondrial calcium accumulation, whereby peroxynitrite promotes formation of superoxide/hydrogen peroxide and the ensuing strand scission of genomic DNA 296
Arsenite-induced mitochondrial superoxide formation: time and concentration requirements for the effects of the metalloid on the endoplasmic reticulum and mitochondria 295
Sodium-dependent transport of ascorbic acid in U937 cell mitochondria. 294
A novel biological role of dehydroascorbic acid: Inhibition of Na+-dependent transport of ascorbic acid. 294
Melatonin protects hippocampal HT22 cells from the effects of serum deprivation specifically targeting mitochondria 294
The mitochondrial transporter of ascorbic acid functions with high affinity in the presence of low millimolar concentrations of sodium and in the absence of calcium and magnesium 288
Mitochondrial ascorbic acid is responsible for enhanced susceptibility of U937 cells to the toxic effects of peroxynitrite 284
Arachidonic acid induces calcium-dependent mitochondrial formation of species promoting strand scission of genomic DNA 281
5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes/macrophages exposed to peroxynitrite. 280
Arsenite induces DNA damage via mitochondrial ROS and induction of mitochondrial permeability transition 277
Calcium signals between the ryanodine receptor- and mitochondria critically regulate the effects of arsenite on mitochondrial superoxide formation and on the ensuing survival vs apoptotic signaling 275
Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid 272
Isolation and preliminary characterization of a Chinese hamster ovary cell line with high-degree resistance to hydrogen peroxide. 261
Cytotoxic impact of DNA single vs double strand breaks in oxidatively injured cells 258
The study of the mechanism of arsenite toxicity in respiration-deficient cells reveals that NADPH oxidase-derived superoxide promotes the same downstream events mediated by mitochondrial superoxide in respiration-proficient cells 256
A novel nonsense mutation in the APTX gene associated with delayed DNA single-strand break removal fails to enhance sensitivity to different genotoxic agents. 252
Cross-resistance to heavy metals in hydrogen peroxide-resistant CHO cell variants. 250
Differentiation-associated loss of ryanodine receptors: a strategy adopted by monocytes/macrophages to prevent the DNA single-strand breakage induced by peroxynitrite. 249
U937 cell necrosis mediated by peroxynitrite is not caused by depletion of ATP and is prevented by arachidonate via an ATP-dependent mechanism. 246
Characterization of two novel SETX mutations in AOA2 patients reveals aspects of the pathophysiological role of senataxin. 244
Intramitochondrial Ascorbic Acid Enhances the Formation of Mitochondrial Superoxide Induced by Peroxynitrite via a Ca(2+)-Independent Mechanism 244
The arachidonate-dependent cytoprotective signaling evoked by peroxynitrite is a general response of the monocyte/macrophage lineage 244
Differentiation of Promonocytic U937 Cells to Monocytes Is Associated with Reduced Mitochondrial Transport of Ascorbic Acid 242
The dual role of mitochondrial superoxide in arsenite toxicity: Signaling at the boundary between apoptotic commitment and cytoprotection 242
Studies with low micromolar levels of ascorbic and dehydroascorbic acid fail to unravel a preferential route for vitamin C uptake and accumulation in U937 cells 241
Crosstalk between ERO1α and ryanodine receptor in arsenite-dependent mitochondrial ROS formation 241
Inhibition of complex III promotes loss of Ca2+ dependence for mitochondrial superoxide formation and permeability transition evoked by peroxynitrite. 240
Modulation of the oxidative response of cultured mammalian cells by L-histidine. 236
The effect of hydrogen peroxide/L-histidine-induced DNA single- vs. double-strand breaks on poly(ADP-ribose)polymerase. 236
Damage to nuclear DNA induced by Shiga toxin 1 and ricin in human endothelial cells 234
Novel SETX variants in a patient with ataxia, neuropathy, and oculomotor apraxia are associated with normal sensitivity to oxidative DNA damaging agents 232
AG8 cells, which are highly resistant to hydrogen peroxide, display collateral sensitivity to the combination of hydrogen peroxide and L-histidine. 231
Survival pathways triggered by peroxynitrite in cells belonging to the monocyte/macrophage lineage 228
The In Vitro Activity of Angelica archangelica L. Essential Oil on Inflammation 224
A downstream role for protein kinase C alpha in the cytosolic phospholipase A2-dependent protective signalling mediated by peroxynitrite in U937 cells. 222
L-histidine-mediated enhancement of hydrogen peroxide-induced cytotoxicity: relationships between DNA single/double strand breakage and cell killing. 222
SVCT2-DEPENDENT PLASMA AND MITOCHONDRIAL MEMBRANE TRANSPORT OF ASCORBIC ACID IN DIFFERENTIATING MYOBLASTS 220
Quercetin prevents DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide: free radical scavenging versus iron chelating mechanism. 219
Peroxynitrite damages U937 cell DNA via the intermediate formation of mitochondrial oxidants. 217
Susceptibility of rat astrocytes to DNA strand scission induced by activation of NADPH oxidase and collateral resistance to the effects of peroxynitrite. 216
Cell signalling and cytotoxicity by peroxynitrite. 214
Peroxynitrite stimulates the activity of cytosolic phospholipase A2 in U937 cells: the extent of arachidonic acid formation regulates the balance between cell survival or death. 212
Products of the phospholipase A2 pathway mediate the dihydrorhodamine fluorescence response evoked by endogenous and exogenous peroxynitrite in PC12 cells. 212
ERK1/2-dependent regulation of U937 cell survival after exposure to peroxynitrite. 210
Characterization of CHO cells variants resistant to hydrogen peroxide 206
Role of Bcl-2 in the arachidonate-mediated survival signaling preventing mitochondrial permeability transition-dependent U937 cell necrosis induced by peroxynitrite 202
Hydrogen peroxide cytotoxicity under conditions of normal or reduced catalase activity in H2O2-sensitive and -resistant Chinese hamster ovary (CHO) cell variants. 202
TNFa enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation 201
Hydrogen peroxide generated at the level of mitochondria in response to peroxynitrite promotes U937 cell death via inhibition of the cytoprotective signalling mediated by cytosolic phospholipase A2 201
Clozapine blunts mitochondrial biogenesis in differentiating adipocytes: The increased ATP demand is met via stimulation of electron transport chain expression and activity in residual mitochondria 198
Electron transport-mediated wasteful consumption of NADH promotes the lethal response of U937 cells to tert-butylhydroperoxide. 198
Intracellular ascorbic acid enhances the DNA single-strand breakage and toxicity induced by peroxynitrite in U937 cells 197
NON-TOXIC CONCENTRATIONS OF PEROXYNITRITE COMMIT U937 CELLS TO MITOCHONDRIAL PERMEABILITY TRANSITION-DEPENDENT NECROSIS THAT IS HOWEVER PREVENTED BY ENDOGENOUS ARACHIDONIC ACID 197
Endogenous and exogenous nitric oxide enhance the DNA strand scission induced by tert-butylhydroperoxide in PC12 cells via peroxynitrite-dependent and independent mechanisms, respectively. 196
Alternative mechanism for hydroperoxide-induced DNA single strand breakage. 195
Pivotal role of superoxides generated in the mitochondrial respiratory chain in peroxynitrite-dependent activation of phospholipase A2. 194
Peroxynitrite mobilizes calcium ions from ryanodine-sensitive stores, a process associated with the mitochondrial accumulation of the cation and the enforced formation of species mediating cleavage of genomic DNA. 194
Development and characterization of hydrogen peroxide-resistant Chinese hamster ovary cell variants--I. Relationship between catalase activity and the induction/stability of the oxidant-resistant phenotype. 192
Different effects of tert-butylhydroperoxide-induced peroxynitrite-dependent and -independent DNA single-strand breakage on PC12 cell poly(ADP-ribose) polymerase activity 192
Different signalling pathways mediate the opposite effects of endogenous versus exogenous nitric oxide on hydroperoxide toxicity in CHP100 neuroblastoma cells 187
Phenolic-rich juice prevents DNA single-strand breakage and cytotoxicity caused by tert-butylhydroperoxide in U937 cells: the role of iron chelation. 187
Peroxynitrite-mediated release of arachidonic acid from PC12 cells 187
Mitochondrial Uptake and Accumulation of Vitamin C: What Can We Learn From Cell Cultures Studies? 182
Calcium-dependent mitochondrial formation of species mediating DNA single strand breakage in U937 cells exposed to sublethal concentrations of tert-butylhydroperoxide. 180
Arsenite impinges on endoplasmic reticulum-mitochondria crosstalk to elicit mitochondrial ROS formation and downstream toxicity 179
Indirect Mechanisms of DNA Strand Scission by Peroxynitrite 178
Functional organization of the endoplasmic reticulum dictates the susceptibility of target cells to arsenite-induced mitochondrial superoxide formation, mitochondrial dysfunction and apoptosis 173
Enhancing effects of intracellular ascorbic acid on peroxynitrite-induced U937 cell death are mediated by mitochondrial events resulting in enhanced sensitivity to peroxynitrite-dependent inhibition of complex III and formation of hydrogen peroxide. 171
The compartmentalised nature of the mechanisms governing superoxide formation and scavenging in cells exposed to arsenite 170
Prostaglandin E2 Signals Through E Prostanoid Receptor 2 to Inhibit Mitochondrial Superoxide Formation and the Ensuing Downstream Cytotoxic and Genotoxic Effects Induced by Arsenite 169
Arsenite enhances ERO1α expression via ryanodine receptor dependent and independent mechanisms 164
Mitochondrial reactive oxygen species: the effects of mitochondrial ascorbic acid vs untargeted and mitochondria-targeted antioxidants 163
Temporal correlation of morphological and biochemical changes with the recruitment of different mechanisms of reactive oxygen species formation during human SW872 cell adipogenic differentiation 159
Development and characterization of hydrogen peroxide-resistant Chinese hamster ovary (CHO) cell variants--II. Relationships between non-protein sulfhydryl levels and the induction/stability of the oxidant-resistant phenotype. 157
Pyruvate enhances DNA single-strand break formation while abolishing cytotoxicity in U937 cells exposed to tert-buytlhydroperoxide. 154
Opposite effects of nitric oxide donors on DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide. 154
Evidence for dissimilar mechanisms of enhancement of inorganic and organic hydroperoxide cytotoxicity by L-histidine. 153
Low Concentrations of Arsenite Target the Intraluminal Inositol 1, 4, 5-Trisphosphate Receptor/Ryanodine Receptor Crosstalk to Significantly Elevate Intracellular Ca2 153
The respiratory-chain poison antimycin A promotes the formation of DNA single-strand breaks and reduces toxicity in U937 cells exposed to tert-butylhydroperoxide. 152
Mechanism of the antimycin A-mediated enhancement of tert-butylhydroperoxide-induced single-strand breakage in DNA. 151
Exogenous histidine as a co-factor which exacerbates the toxicity of hydrogen peroxide in cultured mammalian and bacterial cells 139
The mechanism of the nitric oxide-mediated enhancement of tert-butylhydroperoxide-induced DNA single strand breakage. 134
Stimulation of oxygen consumption promotes mitochondrial calcium accumulation, a process associated with, and causally linked to, enhanced formation of tert-butylhydroperoxide-induced DNA single-strand breaks. 134
Reduced mitochondrial formation of H(2)O(2) is responsible for resistance of dimethyl sufoxide differentiated U937 cells to peroxynitrite 134
NADH-linked substrate-mediated enhancement of mitochondrial calcium accumulation and DNA single-strand breakage elicited by tert-butylhydroperoxide: the source of the cation is a ryanodine-sensitive calcium store . 133
Effects of L-histidine on hydrogen peroxide-induced DNA damage and cytotoxicity in cultured mammalian cells. 133
Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells 130
Nrf2-Mediated Pathway Activated by Prunus spinosa L. (Rosaceae) Fruit Extract: Bioinformatics Analyses and Experimental Validation 127
The inositol 1,4,5-trisphosphate-generating agonist ATP enhances DNA cleavage induced by tert-butylhydroperoxide. 127
Inhibition of activity/expression, or genetic deletion, of ERO1α blunts arsenite geno- and cyto-toxicity 125
Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment 125
ERO1α primes the ryanodine receptor to respond to arsenite with concentration dependent Ca2+ release sequentially triggering two different mechanisms of ROS formation 118
Essential role of the mitochondrial respiratory chain in peroxynitrite-induced strand scission of genomic DNA. 118
null 114
Unveiling the Link Between NADPH Oxidase 2 Activation and Mitochondrial Superoxide Formation in Leukemic Cell Killing Induced by Arsenic Trioxide 108
Calcium-dependent mitochondrial formation of species promoting strand scission of genomic DNA in U937 cells exposed to tert-butylhydroperoxide: the role of arachidonate. 106
Totale 20.980
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Categoria #
all - tutte 80.251
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 80.251
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021108 0 0 0 0 0 0 0 0 0 0 0 108
2021/20221.331 119 169 121 160 65 49 70 84 81 100 35 278
2022/20231.625 169 86 22 196 184 316 12 109 292 60 104 75
2023/2024534 58 35 54 81 44 137 16 20 1 37 1 50
2024/20252.273 71 134 270 85 65 204 384 218 364 127 184 167
2025/20264.810 396 475 511 761 390 304 602 153 365 474 252 127
Totale 21.503