IRIS
GUIDARELLI, ANDREA
 Distribuzione geografica
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Continente #
NA - Nord America 8.446
EU - Europa 4.692
AS - Asia 1.606
Continente sconosciuto - Info sul continente non disponibili 14
SA - Sud America 13
OC - Oceania 6
AF - Africa 5
Totale 14.782
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Nazione #
US - Stati Uniti d'America 8.419
GB - Regno Unito 1.772
CN - Cina 1.077
IT - Italia 754
UA - Ucraina 746
SE - Svezia 483
DE - Germania 300
FI - Finlandia 293
TR - Turchia 251
SG - Singapore 158
IE - Irlanda 146
PL - Polonia 46
FR - Francia 43
KR - Corea 43
RU - Federazione Russa 35
CA - Canada 27
IN - India 19
VN - Vietnam 17
BE - Belgio 16
EU - Europa 13
JP - Giappone 13
IL - Israele 8
NL - Olanda 8
IR - Iran 7
CL - Cile 6
AU - Australia 5
LT - Lituania 5
AT - Austria 4
ES - Italia 4
GR - Grecia 4
MD - Moldavia 4
PT - Portogallo 4
RO - Romania 4
BR - Brasile 3
CH - Svizzera 3
AE - Emirati Arabi Uniti 2
CO - Colombia 2
EC - Ecuador 2
EE - Estonia 2
HK - Hong Kong 2
HU - Ungheria 2
ID - Indonesia 2
LV - Lettonia 2
PK - Pakistan 2
SK - Slovacchia (Repubblica Slovacca) 2
TG - Togo 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
BG - Bulgaria 1
BY - Bielorussia 1
DK - Danimarca 1
EG - Egitto 1
IM - Isola di Man 1
IS - Islanda 1
LB - Libano 1
LU - Lussemburgo 1
MA - Marocco 1
ME - Montenegro 1
MY - Malesia 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
SA - Arabia Saudita 1
SM - San Marino 1
TH - Thailandia 1
TW - Taiwan 1
ZA - Sudafrica 1
Totale 14.782
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Città #
Southend 1.555
Woodbridge 1.278
Fairfield 1.122
Houston 977
Ann Arbor 718
Jacksonville 598
Ashburn 554
Chandler 452
Seattle 449
Wilmington 446
Cambridge 437
Nanjing 286
Urbino 242
Izmir 196
Boardman 176
Dublin 146
Helsinki 146
Singapore 131
New York 103
Princeton 93
Nanchang 91
Beijing 77
Bremen 77
San Mateo 73
Shenyang 58
San Diego 53
Tianjin 50
Hebei 46
Changsha 44
London 39
Kraków 38
Seongnam 38
Istanbul 36
Mülheim 35
Düsseldorf 34
Kunming 34
Jiaxing 28
Shanghai 25
Velikiy Novgorod 25
Guangzhou 24
San Francisco 22
Toronto 21
Santa Clara 20
Hangzhou 19
Jinan 19
Lanzhou 18
Los Angeles 18
Brussels 16
Dong Ket 16
Ningbo 16
Venice 16
Falls Church 14
Ancona 13
Munich 13
Rome 12
Wuppertal 12
Changchun 11
Haikou 11
Acton 10
Zhengzhou 10
Civitanova Marche 9
Dearborn 9
Kilburn 9
Shenzhen 9
Berlin 8
Fano 8
Norwalk 8
Numana 8
Orange 8
Taizhou 8
Tappahannock 8
Casoria 7
Chicago 7
Jesi 7
Messina 7
Paris 7
Pesaro 7
Portland 7
Auburn Hills 6
Des Moines 6
Hefei 6
Islington 6
Sassuolo 6
Bologna 5
Indiana 5
Leawood 5
Mergo 5
Monmouth Junction 5
Napoli 5
Rimini 5
Senigallia 5
Shaoxing 5
Washington 5
Wuhan 5
Augusta 4
Bangalore 4
Bellaria-Igea Marina 4
Borås 4
Caldarola 4
Chisinau 4
Totale 11.587
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Nome #
U937 cell apoptosis induced by arsenite is prevented by low concentrations of mitochondrial ascorbic acid with hardly any effect mediated by the cytosolic fraction of the vitamin 251
Superoxide dictates the mode of U937 cell ascorbic acid uptake and prevents the enhancing effects of the vitamin to otherwise non-toxic levels of reactive oxygen/nitrogen species 227
Cross-resistance to heavy metals in hydrogen peroxide-resistant CHO cell variants. 222
The mitochondrial transporter of ascorbic acid functions with high affinity in the presence of low millimolar concentrations of sodium and in the absence of calcium and magnesium 216
Isolation and preliminary characterization of a Chinese hamster ovary cell line with high-degree resistance to hydrogen peroxide. 216
The study of the mechanism of arsenite toxicity in respiration-deficient cells reveals that NADPH oxidase-derived superoxide promotes the same downstream events mediated by mitochondrial superoxide in respiration-proficient cells 216
The arachidonate-dependent cytoprotective signaling evoked by peroxynitrite is a general response of the monocyte/macrophage lineage 215
Sodium-dependent transport of ascorbic acid in U937 cell mitochondria. 214
Intracellular dehydroascorbic acid inhibits SVCT2-dependent transport of ascorbic acid in mitochondria 214
Mitochondrial ascorbic acid prevents mitochondrial O2.- formation, an event critical for U937 cell apoptosis induced by arsenite through both autophagic-dependent and independent mechanisms 213
The effect of hydrogen peroxide/L-histidine-induced DNA single- vs. double-strand breaks on poly(ADP-ribose)polymerase. 209
Cytotoxic impact of DNA single vs double strand breaks in oxidatively injured cells 207
A novel mechanism, uniquely dependent on mitochondrial calcium accumulation, whereby peroxynitrite promotes formation of superoxide/hydrogen peroxide and the ensuing strand scission of genomic DNA 207
U937 cell necrosis mediated by peroxynitrite is not caused by depletion of ATP and is prevented by arachidonate via an ATP-dependent mechanism. 206
Arsenite induces DNA damage via mitochondrial ROS and induction of mitochondrial permeability transition 206
Arachidonic acid induces calcium-dependent mitochondrial formation of species promoting strand scission of genomic DNA 205
5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes/macrophages exposed to peroxynitrite. 205
Melatonin protects hippocampal HT22 cells from the effects of serum deprivation specifically targeting mitochondria 205
A novel biological role of dehydroascorbic acid: Inhibition of Na+-dependent transport of ascorbic acid. 203
Damage to nuclear DNA induced by Shiga toxin 1 and ricin in human endothelial cells 202
Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid 202
Modulation of the oxidative response of cultured mammalian cells by L-histidine. 201
Mitochondrial ascorbic acid is responsible for enhanced susceptibility of U937 cells to the toxic effects of peroxynitrite 201
Novel SETX variants in a patient with ataxia, neuropathy, and oculomotor apraxia are associated with normal sensitivity to oxidative DNA damaging agents 199
Survival pathways triggered by peroxynitrite in cells belonging to the monocyte/macrophage lineage 199
L-histidine-mediated enhancement of hydrogen peroxide-induced cytotoxicity: relationships between DNA single/double strand breakage and cell killing. 195
Peroxynitrite damages U937 cell DNA via the intermediate formation of mitochondrial oxidants. 186
Studies with low micromolar levels of ascorbic and dehydroascorbic acid fail to unravel a preferential route for vitamin C uptake and accumulation in U937 cells 186
Intramitochondrial Ascorbic Acid Enhances the Formation of Mitochondrial Superoxide Induced by Peroxynitrite via a Ca(2+)-Independent Mechanism 186
Differentiation-associated loss of ryanodine receptors: a strategy adopted by monocytes/macrophages to prevent the DNA single-strand breakage induced by peroxynitrite. 183
The dual role of mitochondrial superoxide in arsenite toxicity: Signaling at the boundary between apoptotic commitment and cytoprotection 182
Differentiation of Promonocytic U937 Cells to Monocytes Is Associated with Reduced Mitochondrial Transport of Ascorbic Acid 181
Quercetin prevents DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide: free radical scavenging versus iron chelating mechanism. 179
Calcium signals between the ryanodine receptor- and mitochondria critically regulate the effects of arsenite on mitochondrial superoxide formation and on the ensuing survival vs apoptotic signaling 179
Peroxynitrite stimulates the activity of cytosolic phospholipase A2 in U937 cells: the extent of arachidonic acid formation regulates the balance between cell survival or death. 178
Inhibition of complex III promotes loss of Ca2+ dependence for mitochondrial superoxide formation and permeability transition evoked by peroxynitrite. 177
Role of Bcl-2 in the arachidonate-mediated survival signaling preventing mitochondrial permeability transition-dependent U937 cell necrosis induced by peroxynitrite 176
Endogenous and exogenous nitric oxide enhance the DNA strand scission induced by tert-butylhydroperoxide in PC12 cells via peroxynitrite-dependent and independent mechanisms, respectively. 175
Characterization of two novel SETX mutations in AOA2 patients reveals aspects of the pathophysiological role of senataxin. 175
Hydrogen peroxide cytotoxicity under conditions of normal or reduced catalase activity in H2O2-sensitive and -resistant Chinese hamster ovary (CHO) cell variants. 175
Peroxynitrite mobilizes calcium ions from ryanodine-sensitive stores, a process associated with the mitochondrial accumulation of the cation and the enforced formation of species mediating cleavage of genomic DNA. 174
Hydrogen peroxide generated at the level of mitochondria in response to peroxynitrite promotes U937 cell death via inhibition of the cytoprotective signalling mediated by cytosolic phospholipase A2 171
Susceptibility of rat astrocytes to DNA strand scission induced by activation of NADPH oxidase and collateral resistance to the effects of peroxynitrite. 171
AG8 cells, which are highly resistant to hydrogen peroxide, display collateral sensitivity to the combination of hydrogen peroxide and L-histidine. 167
Peroxynitrite-mediated release of arachidonic acid from PC12 cells 166
Pivotal role of superoxides generated in the mitochondrial respiratory chain in peroxynitrite-dependent activation of phospholipase A2. 165
ERK1/2-dependent regulation of U937 cell survival after exposure to peroxynitrite. 165
TNFa enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation 164
A novel nonsense mutation in the APTX gene associated with delayed DNA single-strand break removal fails to enhance sensitivity to different genotoxic agents. 164
Products of the phospholipase A2 pathway mediate the dihydrorhodamine fluorescence response evoked by endogenous and exogenous peroxynitrite in PC12 cells. 161
Phenolic-rich juice prevents DNA single-strand breakage and cytotoxicity caused by tert-butylhydroperoxide in U937 cells: the role of iron chelation. 158
Different signalling pathways mediate the opposite effects of endogenous versus exogenous nitric oxide on hydroperoxide toxicity in CHP100 neuroblastoma cells 154
Development and characterization of hydrogen peroxide-resistant Chinese hamster ovary cell variants--I. Relationship between catalase activity and the induction/stability of the oxidant-resistant phenotype. 154
Arsenite-induced mitochondrial superoxide formation: time and concentration requirements for the effects of the metalloid on the endoplasmic reticulum and mitochondria 154
Enhancing effects of intracellular ascorbic acid on peroxynitrite-induced U937 cell death are mediated by mitochondrial events resulting in enhanced sensitivity to peroxynitrite-dependent inhibition of complex III and formation of hydrogen peroxide. 148
Characterization of CHO cells variants resistant to hydrogen peroxide 147
Cell signalling and cytotoxicity by peroxynitrite. 147
A downstream role for protein kinase C alpha in the cytosolic phospholipase A2-dependent protective signalling mediated by peroxynitrite in U937 cells. 146
Electron transport-mediated wasteful consumption of NADH promotes the lethal response of U937 cells to tert-butylhydroperoxide. 145
Indirect Mechanisms of DNA Strand Scission by Peroxynitrite 145
NON-TOXIC CONCENTRATIONS OF PEROXYNITRITE COMMIT U937 CELLS TO MITOCHONDRIAL PERMEABILITY TRANSITION-DEPENDENT NECROSIS THAT IS HOWEVER PREVENTED BY ENDOGENOUS ARACHIDONIC ACID 145
Intracellular ascorbic acid enhances the DNA single-strand breakage and toxicity induced by peroxynitrite in U937 cells 140
Different effects of tert-butylhydroperoxide-induced peroxynitrite-dependent and -independent DNA single-strand breakage on PC12 cell poly(ADP-ribose) polymerase activity 137
Mitochondrial Uptake and Accumulation of Vitamin C: What Can We Learn From Cell Cultures Studies? 134
The In Vitro Activity of Angelica archangelica L. Essential Oil on Inflammation 131
SVCT2-DEPENDENT PLASMA AND MITOCHONDRIAL MEMBRANE TRANSPORT OF ASCORBIC ACID IN DIFFERENTIATING MYOBLASTS 128
Opposite effects of nitric oxide donors on DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide. 125
Alternative mechanism for hydroperoxide-induced DNA single strand breakage. 125
Development and characterization of hydrogen peroxide-resistant Chinese hamster ovary (CHO) cell variants--II. Relationships between non-protein sulfhydryl levels and the induction/stability of the oxidant-resistant phenotype. 124
Calcium-dependent mitochondrial formation of species mediating DNA single strand breakage in U937 cells exposed to sublethal concentrations of tert-butylhydroperoxide. 123
Evidence for dissimilar mechanisms of enhancement of inorganic and organic hydroperoxide cytotoxicity by L-histidine. 122
Mechanism of the antimycin A-mediated enhancement of tert-butylhydroperoxide-induced single-strand breakage in DNA. 118
Low Concentrations of Arsenite Target the Intraluminal Inositol 1, 4, 5-Trisphosphate Receptor/Ryanodine Receptor Crosstalk to Significantly Elevate Intracellular Ca2 118
Prostaglandin E2 Signals Through E Prostanoid Receptor 2 to Inhibit Mitochondrial Superoxide Formation and the Ensuing Downstream Cytotoxic and Genotoxic Effects Induced by Arsenite 118
Pyruvate enhances DNA single-strand break formation while abolishing cytotoxicity in U937 cells exposed to tert-buytlhydroperoxide. 115
null 114
Effects of L-histidine on hydrogen peroxide-induced DNA damage and cytotoxicity in cultured mammalian cells. 110
The inositol 1,4,5-trisphosphate-generating agonist ATP enhances DNA cleavage induced by tert-butylhydroperoxide. 109
Mitochondrial reactive oxygen species: the effects of mitochondrial ascorbic acid vs untargeted and mitochondria-targeted antioxidants 108
NADH-linked substrate-mediated enhancement of mitochondrial calcium accumulation and DNA single-strand breakage elicited by tert-butylhydroperoxide: the source of the cation is a ryanodine-sensitive calcium store . 107
The mechanism of the nitric oxide-mediated enhancement of tert-butylhydroperoxide-induced DNA single strand breakage. 107
Reduced mitochondrial formation of H(2)O(2) is responsible for resistance of dimethyl sufoxide differentiated U937 cells to peroxynitrite 106
Stimulation of oxygen consumption promotes mitochondrial calcium accumulation, a process associated with, and causally linked to, enhanced formation of tert-butylhydroperoxide-induced DNA single-strand breaks. 105
The compartmentalised nature of the mechanisms governing superoxide formation and scavenging in cells exposed to arsenite 104
Exogenous histidine as a co-factor which exacerbates the toxicity of hydrogen peroxide in cultured mammalian and bacterial cells 101
The respiratory-chain poison antimycin A promotes the formation of DNA single-strand breaks and reduces toxicity in U937 cells exposed to tert-butylhydroperoxide. 99
null 97
Essential role of the mitochondrial respiratory chain in peroxynitrite-induced strand scission of genomic DNA. 91
Arsenite impinges on endoplasmic reticulum-mitochondria crosstalk to elicit mitochondrial ROS formation and downstream toxicity 87
Crosstalk between ERO1α and ryanodine receptor in arsenite-dependent mitochondrial ROS formation 75
Functional organization of the endoplasmic reticulum dictates the susceptibility of target cells to arsenite-induced mitochondrial superoxide formation, mitochondrial dysfunction and apoptosis 74
Temporal correlation of morphological and biochemical changes with the recruitment of different mechanisms of reactive oxygen species formation during human SW872 cell adipogenic differentiation 74
Mitochondrial ROS, ER Stress, and Nrf2 Crosstalk in the Regulation of Mitochondrial Apoptosis Induced by Arsenite 56
Arsenite enhances ERO1α expression via ryanodine receptor dependent and independent mechanisms 53
Inhibition of activity/expression, or genetic deletion, of ERO1α blunts arsenite geno- and cyto-toxicity 40
Nrf2-Mediated Pathway Activated by Prunus spinosa L. (Rosaceae) Fruit Extract: Bioinformatics Analyses and Experimental Validation 39
Calcium-dependent mitochondrial formation of species promoting strand scission of genomic DNA in U937 cells exposed to tert-butylhydroperoxide: the role of arachidonate. 34
Effects of nitric oxide on tert-butylhydroperoxide-induced DNA single-strand breakage. 33
Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells 32
ERO1α primes the ryanodine receptor to respond to arsenite with concentration dependent Ca2+ release sequentially triggering two different mechanisms of ROS formation 30
Totale 15.028
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Categoria #
all - tutte 57.607
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 57.607
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.297 0 0 0 0 0 229 260 246 172 158 83 149
2020/20212.003 71 189 149 186 120 165 158 141 289 198 229 108
2021/20221.331 119 169 121 160 65 49 70 84 81 100 35 278
2022/20231.625 169 86 22 196 184 316 12 109 292 60 104 75
2023/2024534 58 35 54 81 44 137 16 20 1 37 1 50
2024/2025629 71 134 270 85 65 4 0 0 0 0 0 0
Totale 15.049