IRIS
GUIDARELLI, ANDREA
 Distribuzione geografica
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Continente #
NA - Nord America 10.458
EU - Europa 6.301
AS - Asia 3.505
SA - Sud America 368
AF - Africa 60
Continente sconosciuto - Info sul continente non disponibili 14
OC - Oceania 9
Totale 20.715
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Nazione #
US - Stati Uniti d'America 10.320
GB - Regno Unito 1.822
CN - Cina 1.609
SG - Singapore 1.146
IT - Italia 926
UA - Ucraina 753
DE - Germania 703
RU - Federazione Russa 540
FI - Finlandia 502
SE - Svezia 500
BR - Brasile 289
TR - Turchia 272
FR - Francia 164
VN - Vietnam 157
IE - Irlanda 149
CA - Canada 77
PL - Polonia 77
IN - India 61
MX - Messico 49
KR - Corea 46
HK - Hong Kong 41
JP - Giappone 36
AR - Argentina 31
NL - Olanda 26
MA - Marocco 25
ES - Italia 24
ZA - Sudafrica 20
BD - Bangladesh 19
BE - Belgio 19
IQ - Iraq 15
LT - Lituania 15
ID - Indonesia 14
EU - Europa 13
CO - Colombia 12
PK - Pakistan 11
CL - Cile 9
IR - Iran 9
SM - San Marino 9
AU - Australia 8
EC - Ecuador 8
GR - Grecia 8
IL - Israele 8
VE - Venezuela 8
AE - Emirati Arabi Uniti 7
AT - Austria 7
PH - Filippine 6
PT - Portogallo 6
UZ - Uzbekistan 6
BG - Bulgaria 5
CZ - Repubblica Ceca 5
JO - Giordania 5
KG - Kirghizistan 5
MD - Moldavia 5
PA - Panama 5
RO - Romania 5
SA - Arabia Saudita 5
CH - Svizzera 4
HU - Ungheria 4
LV - Lettonia 4
PY - Paraguay 4
TH - Thailandia 4
UY - Uruguay 4
BO - Bolivia 3
CR - Costa Rica 3
DZ - Algeria 3
KW - Kuwait 3
LB - Libano 3
LU - Lussemburgo 3
MY - Malesia 3
NO - Norvegia 3
TW - Taiwan 3
DK - Danimarca 2
EE - Estonia 2
EG - Egitto 2
SK - Slovacchia (Repubblica Slovacca) 2
SN - Senegal 2
TG - Togo 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AF - Afghanistan, Repubblica islamica di 1
AL - Albania 1
AZ - Azerbaigian 1
BT - Bhutan 1
BY - Bielorussia 1
CG - Congo 1
ET - Etiopia 1
GE - Georgia 1
HN - Honduras 1
HR - Croazia 1
IM - Isola di Man 1
IS - Islanda 1
JM - Giamaica 1
KE - Kenya 1
KH - Cambogia 1
KY - Cayman, isole 1
LK - Sri Lanka 1
LY - Libia 1
ME - Montenegro 1
MM - Myanmar 1
NP - Nepal 1
NZ - Nuova Zelanda 1
Totale 20.708
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Città #
Southend 1.555
Woodbridge 1.278
Fairfield 1.122
Houston 986
Ashburn 956
Ann Arbor 718
Jacksonville 598
Singapore 569
Chandler 452
Seattle 450
Wilmington 448
Cambridge 437
San Jose 372
Munich 344
Helsinki 315
Dallas 299
Urbino 296
Nanjing 286
Beijing 240
Izmir 197
Boardman 177
Dublin 149
New York 145
Los Angeles 112
Lauterbourg 95
Princeton 93
Nanchang 91
Bremen 77
San Mateo 73
Shenyang 59
Tianjin 55
Chicago 54
Düsseldorf 53
Moscow 53
San Diego 53
Changsha 48
Hebei 46
Ho Chi Minh City 44
London 43
São Paulo 43
Hong Kong 39
Istanbul 39
Kraków 38
Santa Clara 38
Seongnam 38
Shanghai 36
Mülheim 35
Buffalo 34
Hanoi 34
Kunming 34
Toronto 34
Frankfurt am Main 31
Orem 31
San Francisco 30
Guangzhou 29
Jiaxing 28
Velikiy Novgorod 25
Warsaw 25
Tokyo 24
Mexico City 23
Atlanta 22
Council Bluffs 22
Montreal 22
Hangzhou 21
Jinan 21
The Dalles 21
Brooklyn 19
Brussels 19
Denver 19
Salt Lake City 19
Casablanca 18
Lanzhou 18
Rome 18
Stockholm 18
Chennai 17
Turku 17
Des Moines 16
Dong Ket 16
Milan 16
Ningbo 16
Venice 16
Johannesburg 15
Pesaro 15
Falls Church 14
Ancona 13
Shenzhen 13
Tampa 13
Amsterdam 12
Wuppertal 12
Changchun 11
Haikou 11
Manchester 11
Rio de Janeiro 11
Zhengzhou 11
Acton 10
Ankara 10
Bellaria-Igea Marina 10
Elk Grove Village 10
Paris 10
Querétaro 10
Totale 14.739
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Nome #
Intracellular dehydroascorbic acid inhibits SVCT2-dependent transport of ascorbic acid in mitochondria 430
Superoxide dictates the mode of U937 cell ascorbic acid uptake and prevents the enhancing effects of the vitamin to otherwise non-toxic levels of reactive oxygen/nitrogen species 420
Mitochondrial ascorbic acid prevents mitochondrial O2.- formation, an event critical for U937 cell apoptosis induced by arsenite through both autophagic-dependent and independent mechanisms 381
U937 cell apoptosis induced by arsenite is prevented by low concentrations of mitochondrial ascorbic acid with hardly any effect mediated by the cytosolic fraction of the vitamin 324
A novel mechanism, uniquely dependent on mitochondrial calcium accumulation, whereby peroxynitrite promotes formation of superoxide/hydrogen peroxide and the ensuing strand scission of genomic DNA 294
A novel biological role of dehydroascorbic acid: Inhibition of Na+-dependent transport of ascorbic acid. 292
Melatonin protects hippocampal HT22 cells from the effects of serum deprivation specifically targeting mitochondria 291
Sodium-dependent transport of ascorbic acid in U937 cell mitochondria. 289
The mitochondrial transporter of ascorbic acid functions with high affinity in the presence of low millimolar concentrations of sodium and in the absence of calcium and magnesium 281
5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes/macrophages exposed to peroxynitrite. 279
Arachidonic acid induces calcium-dependent mitochondrial formation of species promoting strand scission of genomic DNA 278
Mitochondrial ascorbic acid is responsible for enhanced susceptibility of U937 cells to the toxic effects of peroxynitrite 278
Arsenite induces DNA damage via mitochondrial ROS and induction of mitochondrial permeability transition 274
Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid 271
Calcium signals between the ryanodine receptor- and mitochondria critically regulate the effects of arsenite on mitochondrial superoxide formation and on the ensuing survival vs apoptotic signaling 270
Isolation and preliminary characterization of a Chinese hamster ovary cell line with high-degree resistance to hydrogen peroxide. 257
Cytotoxic impact of DNA single vs double strand breaks in oxidatively injured cells 256
The study of the mechanism of arsenite toxicity in respiration-deficient cells reveals that NADPH oxidase-derived superoxide promotes the same downstream events mediated by mitochondrial superoxide in respiration-proficient cells 254
A novel nonsense mutation in the APTX gene associated with delayed DNA single-strand break removal fails to enhance sensitivity to different genotoxic agents. 250
Cross-resistance to heavy metals in hydrogen peroxide-resistant CHO cell variants. 248
Differentiation-associated loss of ryanodine receptors: a strategy adopted by monocytes/macrophages to prevent the DNA single-strand breakage induced by peroxynitrite. 248
U937 cell necrosis mediated by peroxynitrite is not caused by depletion of ATP and is prevented by arachidonate via an ATP-dependent mechanism. 244
Arsenite-induced mitochondrial superoxide formation: time and concentration requirements for the effects of the metalloid on the endoplasmic reticulum and mitochondria 241
Intramitochondrial Ascorbic Acid Enhances the Formation of Mitochondrial Superoxide Induced by Peroxynitrite via a Ca(2+)-Independent Mechanism 241
Characterization of two novel SETX mutations in AOA2 patients reveals aspects of the pathophysiological role of senataxin. 239
The arachidonate-dependent cytoprotective signaling evoked by peroxynitrite is a general response of the monocyte/macrophage lineage 239
The dual role of mitochondrial superoxide in arsenite toxicity: Signaling at the boundary between apoptotic commitment and cytoprotection 238
Studies with low micromolar levels of ascorbic and dehydroascorbic acid fail to unravel a preferential route for vitamin C uptake and accumulation in U937 cells 237
Inhibition of complex III promotes loss of Ca2+ dependence for mitochondrial superoxide formation and permeability transition evoked by peroxynitrite. 236
Differentiation of Promonocytic U937 Cells to Monocytes Is Associated with Reduced Mitochondrial Transport of Ascorbic Acid 236
The effect of hydrogen peroxide/L-histidine-induced DNA single- vs. double-strand breaks on poly(ADP-ribose)polymerase. 235
Modulation of the oxidative response of cultured mammalian cells by L-histidine. 233
Novel SETX variants in a patient with ataxia, neuropathy, and oculomotor apraxia are associated with normal sensitivity to oxidative DNA damaging agents 231
Crosstalk between ERO1α and ryanodine receptor in arsenite-dependent mitochondrial ROS formation 231
Damage to nuclear DNA induced by Shiga toxin 1 and ricin in human endothelial cells 229
AG8 cells, which are highly resistant to hydrogen peroxide, display collateral sensitivity to the combination of hydrogen peroxide and L-histidine. 227
Survival pathways triggered by peroxynitrite in cells belonging to the monocyte/macrophage lineage 225
The In Vitro Activity of Angelica archangelica L. Essential Oil on Inflammation 222
L-histidine-mediated enhancement of hydrogen peroxide-induced cytotoxicity: relationships between DNA single/double strand breakage and cell killing. 220
A downstream role for protein kinase C alpha in the cytosolic phospholipase A2-dependent protective signalling mediated by peroxynitrite in U937 cells. 219
Peroxynitrite damages U937 cell DNA via the intermediate formation of mitochondrial oxidants. 217
SVCT2-DEPENDENT PLASMA AND MITOCHONDRIAL MEMBRANE TRANSPORT OF ASCORBIC ACID IN DIFFERENTIATING MYOBLASTS 217
Quercetin prevents DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide: free radical scavenging versus iron chelating mechanism. 214
Cell signalling and cytotoxicity by peroxynitrite. 212
Susceptibility of rat astrocytes to DNA strand scission induced by activation of NADPH oxidase and collateral resistance to the effects of peroxynitrite. 211
Products of the phospholipase A2 pathway mediate the dihydrorhodamine fluorescence response evoked by endogenous and exogenous peroxynitrite in PC12 cells. 209
Peroxynitrite stimulates the activity of cytosolic phospholipase A2 in U937 cells: the extent of arachidonic acid formation regulates the balance between cell survival or death. 207
ERK1/2-dependent regulation of U937 cell survival after exposure to peroxynitrite. 207
Characterization of CHO cells variants resistant to hydrogen peroxide 202
Hydrogen peroxide cytotoxicity under conditions of normal or reduced catalase activity in H2O2-sensitive and -resistant Chinese hamster ovary (CHO) cell variants. 201
Role of Bcl-2 in the arachidonate-mediated survival signaling preventing mitochondrial permeability transition-dependent U937 cell necrosis induced by peroxynitrite 200
TNFa enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation 197
Hydrogen peroxide generated at the level of mitochondria in response to peroxynitrite promotes U937 cell death via inhibition of the cytoprotective signalling mediated by cytosolic phospholipase A2 196
Electron transport-mediated wasteful consumption of NADH promotes the lethal response of U937 cells to tert-butylhydroperoxide. 196
Endogenous and exogenous nitric oxide enhance the DNA strand scission induced by tert-butylhydroperoxide in PC12 cells via peroxynitrite-dependent and independent mechanisms, respectively. 194
Peroxynitrite mobilizes calcium ions from ryanodine-sensitive stores, a process associated with the mitochondrial accumulation of the cation and the enforced formation of species mediating cleavage of genomic DNA. 194
Alternative mechanism for hydroperoxide-induced DNA single strand breakage. 193
Pivotal role of superoxides generated in the mitochondrial respiratory chain in peroxynitrite-dependent activation of phospholipase A2. 191
Development and characterization of hydrogen peroxide-resistant Chinese hamster ovary cell variants--I. Relationship between catalase activity and the induction/stability of the oxidant-resistant phenotype. 189
Different effects of tert-butylhydroperoxide-induced peroxynitrite-dependent and -independent DNA single-strand breakage on PC12 cell poly(ADP-ribose) polymerase activity 189
Intracellular ascorbic acid enhances the DNA single-strand breakage and toxicity induced by peroxynitrite in U937 cells 188
NON-TOXIC CONCENTRATIONS OF PEROXYNITRITE COMMIT U937 CELLS TO MITOCHONDRIAL PERMEABILITY TRANSITION-DEPENDENT NECROSIS THAT IS HOWEVER PREVENTED BY ENDOGENOUS ARACHIDONIC ACID 187
Phenolic-rich juice prevents DNA single-strand breakage and cytotoxicity caused by tert-butylhydroperoxide in U937 cells: the role of iron chelation. 186
Different signalling pathways mediate the opposite effects of endogenous versus exogenous nitric oxide on hydroperoxide toxicity in CHP100 neuroblastoma cells 183
Peroxynitrite-mediated release of arachidonic acid from PC12 cells 183
Clozapine blunts mitochondrial biogenesis in differentiating adipocytes: The increased ATP demand is met via stimulation of electron transport chain expression and activity in residual mitochondria 182
Calcium-dependent mitochondrial formation of species mediating DNA single strand breakage in U937 cells exposed to sublethal concentrations of tert-butylhydroperoxide. 180
Mitochondrial Uptake and Accumulation of Vitamin C: What Can We Learn From Cell Cultures Studies? 178
Indirect Mechanisms of DNA Strand Scission by Peroxynitrite 175
Enhancing effects of intracellular ascorbic acid on peroxynitrite-induced U937 cell death are mediated by mitochondrial events resulting in enhanced sensitivity to peroxynitrite-dependent inhibition of complex III and formation of hydrogen peroxide. 171
Functional organization of the endoplasmic reticulum dictates the susceptibility of target cells to arsenite-induced mitochondrial superoxide formation, mitochondrial dysfunction and apoptosis 169
Arsenite impinges on endoplasmic reticulum-mitochondria crosstalk to elicit mitochondrial ROS formation and downstream toxicity 167
The compartmentalised nature of the mechanisms governing superoxide formation and scavenging in cells exposed to arsenite 166
Prostaglandin E2 Signals Through E Prostanoid Receptor 2 to Inhibit Mitochondrial Superoxide Formation and the Ensuing Downstream Cytotoxic and Genotoxic Effects Induced by Arsenite 166
Arsenite enhances ERO1α expression via ryanodine receptor dependent and independent mechanisms 156
Mitochondrial reactive oxygen species: the effects of mitochondrial ascorbic acid vs untargeted and mitochondria-targeted antioxidants 156
Development and characterization of hydrogen peroxide-resistant Chinese hamster ovary (CHO) cell variants--II. Relationships between non-protein sulfhydryl levels and the induction/stability of the oxidant-resistant phenotype. 154
Temporal correlation of morphological and biochemical changes with the recruitment of different mechanisms of reactive oxygen species formation during human SW872 cell adipogenic differentiation 154
Opposite effects of nitric oxide donors on DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide. 152
Pyruvate enhances DNA single-strand break formation while abolishing cytotoxicity in U937 cells exposed to tert-buytlhydroperoxide. 151
Evidence for dissimilar mechanisms of enhancement of inorganic and organic hydroperoxide cytotoxicity by L-histidine. 150
Low Concentrations of Arsenite Target the Intraluminal Inositol 1, 4, 5-Trisphosphate Receptor/Ryanodine Receptor Crosstalk to Significantly Elevate Intracellular Ca2 150
Mechanism of the antimycin A-mediated enhancement of tert-butylhydroperoxide-induced single-strand breakage in DNA. 148
The respiratory-chain poison antimycin A promotes the formation of DNA single-strand breaks and reduces toxicity in U937 cells exposed to tert-butylhydroperoxide. 141
Exogenous histidine as a co-factor which exacerbates the toxicity of hydrogen peroxide in cultured mammalian and bacterial cells 136
The mechanism of the nitric oxide-mediated enhancement of tert-butylhydroperoxide-induced DNA single strand breakage. 132
Reduced mitochondrial formation of H(2)O(2) is responsible for resistance of dimethyl sufoxide differentiated U937 cells to peroxynitrite 132
Effects of L-histidine on hydrogen peroxide-induced DNA damage and cytotoxicity in cultured mammalian cells. 131
NADH-linked substrate-mediated enhancement of mitochondrial calcium accumulation and DNA single-strand breakage elicited by tert-butylhydroperoxide: the source of the cation is a ryanodine-sensitive calcium store . 128
The inositol 1,4,5-trisphosphate-generating agonist ATP enhances DNA cleavage induced by tert-butylhydroperoxide. 126
Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells 125
Stimulation of oxygen consumption promotes mitochondrial calcium accumulation, a process associated with, and causally linked to, enhanced formation of tert-butylhydroperoxide-induced DNA single-strand breaks. 125
Nrf2-Mediated Pathway Activated by Prunus spinosa L. (Rosaceae) Fruit Extract: Bioinformatics Analyses and Experimental Validation 121
Inhibition of activity/expression, or genetic deletion, of ERO1α blunts arsenite geno- and cyto-toxicity 119
Essential role of the mitochondrial respiratory chain in peroxynitrite-induced strand scission of genomic DNA. 118
null 114
Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment 111
ERO1α primes the ryanodine receptor to respond to arsenite with concentration dependent Ca2+ release sequentially triggering two different mechanisms of ROS formation 111
Unveiling the Link Between NADPH Oxidase 2 Activation and Mitochondrial Superoxide Formation in Leukemic Cell Killing Induced by Arsenic Trioxide 104
Calcium-dependent mitochondrial formation of species promoting strand scission of genomic DNA in U937 cells exposed to tert-butylhydroperoxide: the role of arachidonate. 103
Totale 20.553
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Categoria #
all - tutte 76.920
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 76.920
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021535 0 0 0 0 0 0 0 0 0 198 229 108
2021/20221.331 119 169 121 160 65 49 70 84 81 100 35 278
2022/20231.625 169 86 22 196 184 316 12 109 292 60 104 75
2023/2024534 58 35 54 81 44 137 16 20 1 37 1 50
2024/20252.273 71 134 270 85 65 204 384 218 364 127 184 167
2025/20264.322 396 475 511 761 390 304 602 153 365 365 0 0
Totale 21.015