IRIS
GUIDARELLI, ANDREA
 Distribuzione geografica
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Continente #
NA - Nord America 9.798
EU - Europa 5.838
AS - Asia 2.933
SA - Sud America 314
AF - Africa 45
Continente sconosciuto - Info sul continente non disponibili 14
OC - Oceania 8
Totale 18.950
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Nazione #
US - Stati Uniti d'America 9.680
GB - Regno Unito 1.816
CN - Cina 1.533
IT - Italia 895
SG - Singapore 815
UA - Ucraina 753
DE - Germania 688
SE - Svezia 495
FI - Finlandia 444
RU - Federazione Russa 312
TR - Turchia 268
BR - Brasile 257
IE - Irlanda 149
VN - Vietnam 94
CA - Canada 71
FR - Francia 70
PL - Polonia 69
IN - India 43
KR - Corea 43
MX - Messico 41
JP - Giappone 32
MA - Marocco 22
AR - Argentina 21
ES - Italia 21
BE - Belgio 19
NL - Olanda 16
LT - Lituania 14
ZA - Sudafrica 14
BD - Bangladesh 13
EU - Europa 13
CO - Colombia 12
ID - Indonesia 12
HK - Hong Kong 10
SM - San Marino 9
CL - Cile 8
IL - Israele 8
IR - Iran 8
AT - Austria 7
AU - Australia 7
EC - Ecuador 7
GR - Grecia 7
IQ - Iraq 7
PK - Pakistan 7
PT - Portogallo 6
AE - Emirati Arabi Uniti 5
CZ - Repubblica Ceca 5
JO - Giordania 5
KG - Kirghizistan 5
MD - Moldavia 5
RO - Romania 5
BG - Bulgaria 4
CH - Svizzera 4
LV - Lettonia 4
SA - Arabia Saudita 4
HU - Ungheria 3
LB - Libano 3
LU - Lussemburgo 3
MY - Malesia 3
PH - Filippine 3
PY - Paraguay 3
VE - Venezuela 3
BO - Bolivia 2
CR - Costa Rica 2
DK - Danimarca 2
DZ - Algeria 2
EE - Estonia 2
NO - Norvegia 2
SK - Slovacchia (Repubblica Slovacca) 2
SN - Senegal 2
TG - Togo 2
UZ - Uzbekistan 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AF - Afghanistan, Repubblica islamica di 1
AL - Albania 1
AZ - Azerbaigian 1
BY - Bielorussia 1
EG - Egitto 1
GE - Georgia 1
HN - Honduras 1
HR - Croazia 1
IM - Isola di Man 1
IS - Islanda 1
JM - Giamaica 1
KH - Cambogia 1
KW - Kuwait 1
KY - Cayman, isole 1
LK - Sri Lanka 1
ME - Montenegro 1
NZ - Nuova Zelanda 1
QA - Qatar 1
RS - Serbia 1
TH - Thailandia 1
TJ - Tagikistan 1
TN - Tunisia 1
TT - Trinidad e Tobago 1
TW - Taiwan 1
TZ - Tanzania 1
UY - Uruguay 1
Totale 18.950
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Città #
Southend 1.555
Woodbridge 1.278
Fairfield 1.122
Houston 982
Ashburn 863
Ann Arbor 718
Jacksonville 598
Chandler 452
Seattle 450
Wilmington 448
Cambridge 437
Munich 344
Singapore 320
Dallas 297
Urbino 293
Nanjing 286
Helsinki 260
Beijing 228
Izmir 197
Boardman 177
Dublin 149
New York 139
Los Angeles 106
Princeton 93
Nanchang 91
Bremen 77
San Mateo 73
Shenyang 59
Tianjin 55
Chicago 53
Düsseldorf 53
San Diego 53
Moscow 51
Changsha 48
Hebei 46
London 42
São Paulo 41
Kraków 38
Seongnam 38
Istanbul 37
Mülheim 35
Buffalo 34
Kunming 34
Shanghai 34
Santa Clara 32
Toronto 32
San Francisco 29
Guangzhou 28
Jiaxing 28
Ho Chi Minh City 25
Velikiy Novgorod 25
Frankfurt am Main 23
Jinan 21
Tokyo 21
Hangzhou 20
Mexico City 20
Brussels 19
Montreal 19
Warsaw 19
Brooklyn 18
Casablanca 18
Lanzhou 18
Hanoi 17
Turku 17
Denver 16
Dong Ket 16
Ningbo 16
Rome 16
Venice 16
Des Moines 15
Milan 15
Orem 15
Pesaro 15
Atlanta 14
Falls Church 14
Ancona 13
Stockholm 13
Tampa 13
Shenzhen 12
Wuppertal 12
Changchun 11
Chennai 11
Haikou 11
Johannesburg 11
Zhengzhou 11
Acton 10
Ankara 10
Bellaria-Igea Marina 10
Paris 10
Salt Lake City 10
Civitanova Marche 9
Dearborn 9
Jyväskylä 9
Kilburn 9
Manchester 9
Querétaro 9
Taizhou 9
Berlin 8
Fano 8
Hong Kong 8
Totale 13.656
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Nome #
Intracellular dehydroascorbic acid inhibits SVCT2-dependent transport of ascorbic acid in mitochondria 410
Superoxide dictates the mode of U937 cell ascorbic acid uptake and prevents the enhancing effects of the vitamin to otherwise non-toxic levels of reactive oxygen/nitrogen species 408
Mitochondrial ascorbic acid prevents mitochondrial O2.- formation, an event critical for U937 cell apoptosis induced by arsenite through both autophagic-dependent and independent mechanisms 365
U937 cell apoptosis induced by arsenite is prevented by low concentrations of mitochondrial ascorbic acid with hardly any effect mediated by the cytosolic fraction of the vitamin 298
Sodium-dependent transport of ascorbic acid in U937 cell mitochondria. 272
A novel biological role of dehydroascorbic acid: Inhibition of Na+-dependent transport of ascorbic acid. 269
Melatonin protects hippocampal HT22 cells from the effects of serum deprivation specifically targeting mitochondria 266
A novel mechanism, uniquely dependent on mitochondrial calcium accumulation, whereby peroxynitrite promotes formation of superoxide/hydrogen peroxide and the ensuing strand scission of genomic DNA 265
5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes/macrophages exposed to peroxynitrite. 263
The mitochondrial transporter of ascorbic acid functions with high affinity in the presence of low millimolar concentrations of sodium and in the absence of calcium and magnesium 258
Arsenite induces DNA damage via mitochondrial ROS and induction of mitochondrial permeability transition 257
Arachidonic acid induces calcium-dependent mitochondrial formation of species promoting strand scission of genomic DNA 255
Mitochondrial ascorbic acid is responsible for enhanced susceptibility of U937 cells to the toxic effects of peroxynitrite 249
Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid 247
Cross-resistance to heavy metals in hydrogen peroxide-resistant CHO cell variants. 243
The study of the mechanism of arsenite toxicity in respiration-deficient cells reveals that NADPH oxidase-derived superoxide promotes the same downstream events mediated by mitochondrial superoxide in respiration-proficient cells 243
Calcium signals between the ryanodine receptor- and mitochondria critically regulate the effects of arsenite on mitochondrial superoxide formation and on the ensuing survival vs apoptotic signaling 241
Cytotoxic impact of DNA single vs double strand breaks in oxidatively injured cells 239
Differentiation-associated loss of ryanodine receptors: a strategy adopted by monocytes/macrophages to prevent the DNA single-strand breakage induced by peroxynitrite. 234
Isolation and preliminary characterization of a Chinese hamster ovary cell line with high-degree resistance to hydrogen peroxide. 233
The arachidonate-dependent cytoprotective signaling evoked by peroxynitrite is a general response of the monocyte/macrophage lineage 233
Intramitochondrial Ascorbic Acid Enhances the Formation of Mitochondrial Superoxide Induced by Peroxynitrite via a Ca(2+)-Independent Mechanism 232
A novel nonsense mutation in the APTX gene associated with delayed DNA single-strand break removal fails to enhance sensitivity to different genotoxic agents. 231
U937 cell necrosis mediated by peroxynitrite is not caused by depletion of ATP and is prevented by arachidonate via an ATP-dependent mechanism. 230
Studies with low micromolar levels of ascorbic and dehydroascorbic acid fail to unravel a preferential route for vitamin C uptake and accumulation in U937 cells 227
The effect of hydrogen peroxide/L-histidine-induced DNA single- vs. double-strand breaks on poly(ADP-ribose)polymerase. 226
Differentiation of Promonocytic U937 Cells to Monocytes Is Associated with Reduced Mitochondrial Transport of Ascorbic Acid 225
Modulation of the oxidative response of cultured mammalian cells by L-histidine. 223
Characterization of two novel SETX mutations in AOA2 patients reveals aspects of the pathophysiological role of senataxin. 223
Inhibition of complex III promotes loss of Ca2+ dependence for mitochondrial superoxide formation and permeability transition evoked by peroxynitrite. 222
Damage to nuclear DNA induced by Shiga toxin 1 and ricin in human endothelial cells 219
Novel SETX variants in a patient with ataxia, neuropathy, and oculomotor apraxia are associated with normal sensitivity to oxidative DNA damaging agents 217
Survival pathways triggered by peroxynitrite in cells belonging to the monocyte/macrophage lineage 215
AG8 cells, which are highly resistant to hydrogen peroxide, display collateral sensitivity to the combination of hydrogen peroxide and L-histidine. 214
The dual role of mitochondrial superoxide in arsenite toxicity: Signaling at the boundary between apoptotic commitment and cytoprotection 213
Arsenite-induced mitochondrial superoxide formation: time and concentration requirements for the effects of the metalloid on the endoplasmic reticulum and mitochondria 213
L-histidine-mediated enhancement of hydrogen peroxide-induced cytotoxicity: relationships between DNA single/double strand breakage and cell killing. 210
The In Vitro Activity of Angelica archangelica L. Essential Oil on Inflammation 209
Peroxynitrite damages U937 cell DNA via the intermediate formation of mitochondrial oxidants. 208
A downstream role for protein kinase C alpha in the cytosolic phospholipase A2-dependent protective signalling mediated by peroxynitrite in U937 cells. 204
Products of the phospholipase A2 pathway mediate the dihydrorhodamine fluorescence response evoked by endogenous and exogenous peroxynitrite in PC12 cells. 204
ERK1/2-dependent regulation of U937 cell survival after exposure to peroxynitrite. 203
Susceptibility of rat astrocytes to DNA strand scission induced by activation of NADPH oxidase and collateral resistance to the effects of peroxynitrite. 196
Cell signalling and cytotoxicity by peroxynitrite. 196
Quercetin prevents DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide: free radical scavenging versus iron chelating mechanism. 195
Role of Bcl-2 in the arachidonate-mediated survival signaling preventing mitochondrial permeability transition-dependent U937 cell necrosis induced by peroxynitrite 194
Peroxynitrite stimulates the activity of cytosolic phospholipase A2 in U937 cells: the extent of arachidonic acid formation regulates the balance between cell survival or death. 193
Hydrogen peroxide cytotoxicity under conditions of normal or reduced catalase activity in H2O2-sensitive and -resistant Chinese hamster ovary (CHO) cell variants. 193
Characterization of CHO cells variants resistant to hydrogen peroxide 192
SVCT2-DEPENDENT PLASMA AND MITOCHONDRIAL MEMBRANE TRANSPORT OF ASCORBIC ACID IN DIFFERENTIATING MYOBLASTS 189
Endogenous and exogenous nitric oxide enhance the DNA strand scission induced by tert-butylhydroperoxide in PC12 cells via peroxynitrite-dependent and independent mechanisms, respectively. 188
Peroxynitrite mobilizes calcium ions from ryanodine-sensitive stores, a process associated with the mitochondrial accumulation of the cation and the enforced formation of species mediating cleavage of genomic DNA. 188
Hydrogen peroxide generated at the level of mitochondria in response to peroxynitrite promotes U937 cell death via inhibition of the cytoprotective signalling mediated by cytosolic phospholipase A2 187
TNFa enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation 181
Pivotal role of superoxides generated in the mitochondrial respiratory chain in peroxynitrite-dependent activation of phospholipase A2. 180
Electron transport-mediated wasteful consumption of NADH promotes the lethal response of U937 cells to tert-butylhydroperoxide. 179
Peroxynitrite-mediated release of arachidonic acid from PC12 cells 179
NON-TOXIC CONCENTRATIONS OF PEROXYNITRITE COMMIT U937 CELLS TO MITOCHONDRIAL PERMEABILITY TRANSITION-DEPENDENT NECROSIS THAT IS HOWEVER PREVENTED BY ENDOGENOUS ARACHIDONIC ACID 179
Alternative mechanism for hydroperoxide-induced DNA single strand breakage. 178
Intracellular ascorbic acid enhances the DNA single-strand breakage and toxicity induced by peroxynitrite in U937 cells 177
Crosstalk between ERO1α and ryanodine receptor in arsenite-dependent mitochondrial ROS formation 177
Different effects of tert-butylhydroperoxide-induced peroxynitrite-dependent and -independent DNA single-strand breakage on PC12 cell poly(ADP-ribose) polymerase activity 176
Phenolic-rich juice prevents DNA single-strand breakage and cytotoxicity caused by tert-butylhydroperoxide in U937 cells: the role of iron chelation. 175
Different signalling pathways mediate the opposite effects of endogenous versus exogenous nitric oxide on hydroperoxide toxicity in CHP100 neuroblastoma cells 173
Development and characterization of hydrogen peroxide-resistant Chinese hamster ovary cell variants--I. Relationship between catalase activity and the induction/stability of the oxidant-resistant phenotype. 171
Calcium-dependent mitochondrial formation of species mediating DNA single strand breakage in U937 cells exposed to sublethal concentrations of tert-butylhydroperoxide. 171
Indirect Mechanisms of DNA Strand Scission by Peroxynitrite 164
Enhancing effects of intracellular ascorbic acid on peroxynitrite-induced U937 cell death are mediated by mitochondrial events resulting in enhanced sensitivity to peroxynitrite-dependent inhibition of complex III and formation of hydrogen peroxide. 164
Mitochondrial Uptake and Accumulation of Vitamin C: What Can We Learn From Cell Cultures Studies? 160
Prostaglandin E2 Signals Through E Prostanoid Receptor 2 to Inhibit Mitochondrial Superoxide Formation and the Ensuing Downstream Cytotoxic and Genotoxic Effects Induced by Arsenite 152
The compartmentalised nature of the mechanisms governing superoxide formation and scavenging in cells exposed to arsenite 151
Opposite effects of nitric oxide donors on DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide. 143
Development and characterization of hydrogen peroxide-resistant Chinese hamster ovary (CHO) cell variants--II. Relationships between non-protein sulfhydryl levels and the induction/stability of the oxidant-resistant phenotype. 141
Low Concentrations of Arsenite Target the Intraluminal Inositol 1, 4, 5-Trisphosphate Receptor/Ryanodine Receptor Crosstalk to Significantly Elevate Intracellular Ca2 141
Arsenite impinges on endoplasmic reticulum-mitochondria crosstalk to elicit mitochondrial ROS formation and downstream toxicity 141
Evidence for dissimilar mechanisms of enhancement of inorganic and organic hydroperoxide cytotoxicity by L-histidine. 139
Pyruvate enhances DNA single-strand break formation while abolishing cytotoxicity in U937 cells exposed to tert-buytlhydroperoxide. 137
Mitochondrial reactive oxygen species: the effects of mitochondrial ascorbic acid vs untargeted and mitochondria-targeted antioxidants 135
Mechanism of the antimycin A-mediated enhancement of tert-butylhydroperoxide-induced single-strand breakage in DNA. 133
Exogenous histidine as a co-factor which exacerbates the toxicity of hydrogen peroxide in cultured mammalian and bacterial cells 132
The respiratory-chain poison antimycin A promotes the formation of DNA single-strand breaks and reduces toxicity in U937 cells exposed to tert-butylhydroperoxide. 131
Functional organization of the endoplasmic reticulum dictates the susceptibility of target cells to arsenite-induced mitochondrial superoxide formation, mitochondrial dysfunction and apoptosis 131
Arsenite enhances ERO1α expression via ryanodine receptor dependent and independent mechanisms 128
Effects of L-histidine on hydrogen peroxide-induced DNA damage and cytotoxicity in cultured mammalian cells. 128
Reduced mitochondrial formation of H(2)O(2) is responsible for resistance of dimethyl sufoxide differentiated U937 cells to peroxynitrite 125
The mechanism of the nitric oxide-mediated enhancement of tert-butylhydroperoxide-induced DNA single strand breakage. 124
Temporal correlation of morphological and biochemical changes with the recruitment of different mechanisms of reactive oxygen species formation during human SW872 cell adipogenic differentiation 122
Stimulation of oxygen consumption promotes mitochondrial calcium accumulation, a process associated with, and causally linked to, enhanced formation of tert-butylhydroperoxide-induced DNA single-strand breaks. 121
The inositol 1,4,5-trisphosphate-generating agonist ATP enhances DNA cleavage induced by tert-butylhydroperoxide. 121
NADH-linked substrate-mediated enhancement of mitochondrial calcium accumulation and DNA single-strand breakage elicited by tert-butylhydroperoxide: the source of the cation is a ryanodine-sensitive calcium store . 120
null 114
Essential role of the mitochondrial respiratory chain in peroxynitrite-induced strand scission of genomic DNA. 106
Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells 101
null 97
Inhibition of activity/expression, or genetic deletion, of ERO1α blunts arsenite geno- and cyto-toxicity 90
Nrf2-Mediated Pathway Activated by Prunus spinosa L. (Rosaceae) Fruit Extract: Bioinformatics Analyses and Experimental Validation 87
ERO1α primes the ryanodine receptor to respond to arsenite with concentration dependent Ca2+ release sequentially triggering two different mechanisms of ROS formation 87
Calcium-dependent mitochondrial formation of species promoting strand scission of genomic DNA in U937 cells exposed to tert-butylhydroperoxide: the role of arachidonate. 87
Mitochondrial ROS, ER Stress, and Nrf2 Crosstalk in the Regulation of Mitochondrial Apoptosis Induced by Arsenite 83
Clozapine blunts mitochondrial biogenesis in differentiating adipocytes: The increased ATP demand is met via stimulation of electron transport chain expression and activity in residual mitochondria 82
Totale 18.941
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Categoria #
all - tutte 73.834
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 73.834
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.288 0 0 0 0 0 165 158 141 289 198 229 108
2021/20221.331 119 169 121 160 65 49 70 84 81 100 35 278
2022/20231.625 169 86 22 196 184 316 12 109 292 60 104 75
2023/2024534 58 35 54 81 44 137 16 20 1 37 1 50
2024/20252.273 71 134 270 85 65 204 384 218 364 127 184 167
2025/20262.556 396 475 511 761 390 23 0 0 0 0 0 0
Totale 19.249