IRIS
GUIDARELLI, ANDREA
 Distribuzione geografica
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Continente #
NA - Nord America 11.823
EU - Europa 6.449
AS - Asia 3.705
SA - Sud America 403
Continente sconosciuto - Info sul continente non disponibili 319
AF - Africa 64
OC - Oceania 10
Totale 22.773
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Nazione #
US - Stati Uniti d'America 11.589
GB - Regno Unito 1.845
CN - Cina 1.669
SG - Singapore 1.210
IT - Italia 1.028
UA - Ucraina 755
DE - Germania 704
RU - Federazione Russa 541
FI - Finlandia 502
SE - Svezia 500
BR - Brasile 302
TR - Turchia 272
FR - Francia 167
VN - Vietnam 160
IE - Irlanda 149
CA - Canada 117
PL - Polonia 78
BD - Bangladesh 66
IN - India 62
MX - Messico 55
HK - Hong Kong 51
KR - Corea 47
JP - Giappone 38
AR - Argentina 33
NL - Olanda 30
MA - Marocco 27
ES - Italia 24
ZA - Sudafrica 20
BE - Belgio 19
CO - Colombia 19
ID - Indonesia 19
LT - Lituania 17
IQ - Iraq 15
EC - Ecuador 13
EU - Europa 13
VE - Venezuela 13
HN - Honduras 11
PK - Pakistan 11
CL - Cile 10
CR - Costa Rica 10
AU - Australia 9
IL - Israele 9
IR - Iran 9
SM - San Marino 9
AE - Emirati Arabi Uniti 8
GR - Grecia 8
JM - Giamaica 8
PH - Filippine 8
AT - Austria 7
TT - Trinidad e Tobago 7
EE - Estonia 6
PT - Portogallo 6
RO - Romania 6
UZ - Uzbekistan 6
BG - Bulgaria 5
CW - ???statistics.table.value.countryCode.CW??? 5
CZ - Repubblica Ceca 5
GT - Guatemala 5
JO - Giordania 5
KG - Kirghizistan 5
MD - Moldavia 5
PA - Panama 5
SA - Arabia Saudita 5
TH - Thailandia 5
UY - Uruguay 5
CH - Svizzera 4
DK - Danimarca 4
HU - Ungheria 4
LV - Lettonia 4
MY - Malesia 4
PY - Paraguay 4
SV - El Salvador 4
AL - Albania 3
BO - Bolivia 3
DZ - Algeria 3
KW - Kuwait 3
LB - Libano 3
LU - Lussemburgo 3
NI - Nicaragua 3
NO - Norvegia 3
PR - Porto Rico 3
TW - Taiwan 3
CG - Congo 2
EG - Egitto 2
NP - Nepal 2
SK - Slovacchia (Repubblica Slovacca) 2
SN - Senegal 2
TG - Togo 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AF - Afghanistan, Repubblica islamica di 1
AG - Antigua e Barbuda 1
AW - Aruba 1
AZ - Azerbaigian 1
BT - Bhutan 1
BY - Bielorussia 1
BZ - Belize 1
ET - Etiopia 1
GE - Georgia 1
GP - Guadalupe 1
HR - Croazia 1
Totale 22.454
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Città #
Southend 1.555
Woodbridge 1.278
Ashburn 1.225
Fairfield 1.122
Houston 990
Ann Arbor 718
Jacksonville 603
Singapore 582
San Jose 483
Seattle 457
Chandler 452
Wilmington 449
Cambridge 438
Munich 344
Dallas 326
Helsinki 315
Urbino 300
Nanjing 286
Beijing 257
Izmir 197
Boardman 192
New York 171
Council Bluffs 169
Dublin 149
Los Angeles 143
Lauterbourg 95
Santa Clara 95
Princeton 93
Nanchang 91
Bremen 77
Chicago 74
San Mateo 73
Shenyang 59
Tianjin 56
San Diego 55
Düsseldorf 53
Moscow 53
Changsha 49
Hong Kong 48
Hebei 46
Ho Chi Minh City 46
São Paulo 46
London 45
Toronto 45
Columbus 44
San Francisco 41
Istanbul 39
Shanghai 39
Buffalo 38
Kraków 38
Seongnam 38
Orem 37
Hanoi 35
Mülheim 35
Kunming 34
Frankfurt am Main 31
Phoenix 31
Atlanta 30
Guangzhou 29
Montreal 29
Denver 28
Jiaxing 28
Rome 28
Milan 27
Tokyo 26
Warsaw 26
Brooklyn 25
Mexico City 25
North Bergen 25
Velikiy Novgorod 25
Salt Lake City 23
Hangzhou 22
Jinan 21
The Dalles 21
Casablanca 20
Brussels 19
Lanzhou 18
Stockholm 18
Chennai 17
Turku 17
Venice 17
Des Moines 16
Dong Ket 16
Ningbo 16
Falls Church 15
Johannesburg 15
Pesaro 15
Amsterdam 14
Ancona 14
Tampa 14
Rimini 13
Shenzhen 13
Wuppertal 12
Changchun 11
Elk Grove Village 11
Haikou 11
Manchester 11
Naples 11
Rio de Janeiro 11
Zhengzhou 11
Totale 15.694
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Nome #
Intracellular dehydroascorbic acid inhibits SVCT2-dependent transport of ascorbic acid in mitochondria 443
Superoxide dictates the mode of U937 cell ascorbic acid uptake and prevents the enhancing effects of the vitamin to otherwise non-toxic levels of reactive oxygen/nitrogen species 428
Mitochondrial ascorbic acid prevents mitochondrial O2.- formation, an event critical for U937 cell apoptosis induced by arsenite through both autophagic-dependent and independent mechanisms 396
U937 cell apoptosis induced by arsenite is prevented by low concentrations of mitochondrial ascorbic acid with hardly any effect mediated by the cytosolic fraction of the vitamin 344
A novel biological role of dehydroascorbic acid: Inhibition of Na+-dependent transport of ascorbic acid. 311
Mitochondrial Uptake and Accumulation of Vitamin C: What Can We Learn From Cell Cultures Studies? 309
Arsenite-induced mitochondrial superoxide formation: time and concentration requirements for the effects of the metalloid on the endoplasmic reticulum and mitochondria 309
Melatonin protects hippocampal HT22 cells from the effects of serum deprivation specifically targeting mitochondria 304
A novel mechanism, uniquely dependent on mitochondrial calcium accumulation, whereby peroxynitrite promotes formation of superoxide/hydrogen peroxide and the ensuing strand scission of genomic DNA 303
Sodium-dependent transport of ascorbic acid in U937 cell mitochondria. 300
The mitochondrial transporter of ascorbic acid functions with high affinity in the presence of low millimolar concentrations of sodium and in the absence of calcium and magnesium 299
Arachidonic acid induces calcium-dependent mitochondrial formation of species promoting strand scission of genomic DNA 294
Arsenite induces DNA damage via mitochondrial ROS and induction of mitochondrial permeability transition 294
Mitochondrial ascorbic acid is responsible for enhanced susceptibility of U937 cells to the toxic effects of peroxynitrite 291
5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes/macrophages exposed to peroxynitrite. 288
Calcium signals between the ryanodine receptor- and mitochondria critically regulate the effects of arsenite on mitochondrial superoxide formation and on the ensuing survival vs apoptotic signaling 283
Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid 281
The study of the mechanism of arsenite toxicity in respiration-deficient cells reveals that NADPH oxidase-derived superoxide promotes the same downstream events mediated by mitochondrial superoxide in respiration-proficient cells 274
Isolation and preliminary characterization of a Chinese hamster ovary cell line with high-degree resistance to hydrogen peroxide. 272
Cytotoxic impact of DNA single vs double strand breaks in oxidatively injured cells 270
Crosstalk between ERO1α and ryanodine receptor in arsenite-dependent mitochondrial ROS formation 268
A novel nonsense mutation in the APTX gene associated with delayed DNA single-strand break removal fails to enhance sensitivity to different genotoxic agents. 263
Cross-resistance to heavy metals in hydrogen peroxide-resistant CHO cell variants. 262
Characterization of two novel SETX mutations in AOA2 patients reveals aspects of the pathophysiological role of senataxin. 262
Intramitochondrial Ascorbic Acid Enhances the Formation of Mitochondrial Superoxide Induced by Peroxynitrite via a Ca(2+)-Independent Mechanism 260
U937 cell necrosis mediated by peroxynitrite is not caused by depletion of ATP and is prevented by arachidonate via an ATP-dependent mechanism. 255
Differentiation-associated loss of ryanodine receptors: a strategy adopted by monocytes/macrophages to prevent the DNA single-strand breakage induced by peroxynitrite. 255
The dual role of mitochondrial superoxide in arsenite toxicity: Signaling at the boundary between apoptotic commitment and cytoprotection 255
The arachidonate-dependent cytoprotective signaling evoked by peroxynitrite is a general response of the monocyte/macrophage lineage 255
Inhibition of complex III promotes loss of Ca2+ dependence for mitochondrial superoxide formation and permeability transition evoked by peroxynitrite. 252
Differentiation of Promonocytic U937 Cells to Monocytes Is Associated with Reduced Mitochondrial Transport of Ascorbic Acid 250
Studies with low micromolar levels of ascorbic and dehydroascorbic acid fail to unravel a preferential route for vitamin C uptake and accumulation in U937 cells 249
AG8 cells, which are highly resistant to hydrogen peroxide, display collateral sensitivity to the combination of hydrogen peroxide and L-histidine. 245
Modulation of the oxidative response of cultured mammalian cells by L-histidine. 244
The effect of hydrogen peroxide/L-histidine-induced DNA single- vs. double-strand breaks on poly(ADP-ribose)polymerase. 244
Damage to nuclear DNA induced by Shiga toxin 1 and ricin in human endothelial cells 242
Novel SETX variants in a patient with ataxia, neuropathy, and oculomotor apraxia are associated with normal sensitivity to oxidative DNA damaging agents 238
Cell signalling and cytotoxicity by peroxynitrite. 236
Survival pathways triggered by peroxynitrite in cells belonging to the monocyte/macrophage lineage 236
Quercetin prevents DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide: free radical scavenging versus iron chelating mechanism. 235
The In Vitro Activity of Angelica archangelica L. Essential Oil on Inflammation 234
A downstream role for protein kinase C alpha in the cytosolic phospholipase A2-dependent protective signalling mediated by peroxynitrite in U937 cells. 232
Peroxynitrite damages U937 cell DNA via the intermediate formation of mitochondrial oxidants. 227
L-histidine-mediated enhancement of hydrogen peroxide-induced cytotoxicity: relationships between DNA single/double strand breakage and cell killing. 227
Susceptibility of rat astrocytes to DNA strand scission induced by activation of NADPH oxidase and collateral resistance to the effects of peroxynitrite. 224
Clozapine blunts mitochondrial biogenesis in differentiating adipocytes: The increased ATP demand is met via stimulation of electron transport chain expression and activity in residual mitochondria 223
SVCT2-DEPENDENT PLASMA AND MITOCHONDRIAL MEMBRANE TRANSPORT OF ASCORBIC ACID IN DIFFERENTIATING MYOBLASTS 223
ERK1/2-dependent regulation of U937 cell survival after exposure to peroxynitrite. 221
Intracellular ascorbic acid enhances the DNA single-strand breakage and toxicity induced by peroxynitrite in U937 cells 217
Products of the phospholipase A2 pathway mediate the dihydrorhodamine fluorescence response evoked by endogenous and exogenous peroxynitrite in PC12 cells. 216
Hydrogen peroxide cytotoxicity under conditions of normal or reduced catalase activity in H2O2-sensitive and -resistant Chinese hamster ovary (CHO) cell variants. 215
Peroxynitrite stimulates the activity of cytosolic phospholipase A2 in U937 cells: the extent of arachidonic acid formation regulates the balance between cell survival or death. 214
Characterization of CHO cells variants resistant to hydrogen peroxide 214
Role of Bcl-2 in the arachidonate-mediated survival signaling preventing mitochondrial permeability transition-dependent U937 cell necrosis induced by peroxynitrite 213
Hydrogen peroxide generated at the level of mitochondria in response to peroxynitrite promotes U937 cell death via inhibition of the cytoprotective signalling mediated by cytosolic phospholipase A2 209
Electron transport-mediated wasteful consumption of NADH promotes the lethal response of U937 cells to tert-butylhydroperoxide. 208
TNFa enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation 207
Peroxynitrite mobilizes calcium ions from ryanodine-sensitive stores, a process associated with the mitochondrial accumulation of the cation and the enforced formation of species mediating cleavage of genomic DNA. 206
Alternative mechanism for hydroperoxide-induced DNA single strand breakage. 202
NON-TOXIC CONCENTRATIONS OF PEROXYNITRITE COMMIT U937 CELLS TO MITOCHONDRIAL PERMEABILITY TRANSITION-DEPENDENT NECROSIS THAT IS HOWEVER PREVENTED BY ENDOGENOUS ARACHIDONIC ACID 202
Calcium-dependent mitochondrial formation of species mediating DNA single strand breakage in U937 cells exposed to sublethal concentrations of tert-butylhydroperoxide. 201
Endogenous and exogenous nitric oxide enhance the DNA strand scission induced by tert-butylhydroperoxide in PC12 cells via peroxynitrite-dependent and independent mechanisms, respectively. 200
Pivotal role of superoxides generated in the mitochondrial respiratory chain in peroxynitrite-dependent activation of phospholipase A2. 199
Different effects of tert-butylhydroperoxide-induced peroxynitrite-dependent and -independent DNA single-strand breakage on PC12 cell poly(ADP-ribose) polymerase activity 198
Different signalling pathways mediate the opposite effects of endogenous versus exogenous nitric oxide on hydroperoxide toxicity in CHP100 neuroblastoma cells 195
Development and characterization of hydrogen peroxide-resistant Chinese hamster ovary cell variants--I. Relationship between catalase activity and the induction/stability of the oxidant-resistant phenotype. 195
Arsenite impinges on endoplasmic reticulum-mitochondria crosstalk to elicit mitochondrial ROS formation and downstream toxicity 195
Phenolic-rich juice prevents DNA single-strand breakage and cytotoxicity caused by tert-butylhydroperoxide in U937 cells: the role of iron chelation. 194
Peroxynitrite-mediated release of arachidonic acid from PC12 cells 193
Indirect Mechanisms of DNA Strand Scission by Peroxynitrite 187
Functional organization of the endoplasmic reticulum dictates the susceptibility of target cells to arsenite-induced mitochondrial superoxide formation, mitochondrial dysfunction and apoptosis 184
Arsenite enhances ERO1α expression via ryanodine receptor dependent and independent mechanisms 183
Enhancing effects of intracellular ascorbic acid on peroxynitrite-induced U937 cell death are mediated by mitochondrial events resulting in enhanced sensitivity to peroxynitrite-dependent inhibition of complex III and formation of hydrogen peroxide. 181
The compartmentalised nature of the mechanisms governing superoxide formation and scavenging in cells exposed to arsenite 181
Prostaglandin E2 Signals Through E Prostanoid Receptor 2 to Inhibit Mitochondrial Superoxide Formation and the Ensuing Downstream Cytotoxic and Genotoxic Effects Induced by Arsenite 176
Mitochondrial reactive oxygen species: the effects of mitochondrial ascorbic acid vs untargeted and mitochondria-targeted antioxidants 172
Development and characterization of hydrogen peroxide-resistant Chinese hamster ovary (CHO) cell variants--II. Relationships between non-protein sulfhydryl levels and the induction/stability of the oxidant-resistant phenotype. 170
Evidence for dissimilar mechanisms of enhancement of inorganic and organic hydroperoxide cytotoxicity by L-histidine. 169
Pyruvate enhances DNA single-strand break formation while abolishing cytotoxicity in U937 cells exposed to tert-buytlhydroperoxide. 168
Temporal correlation of morphological and biochemical changes with the recruitment of different mechanisms of reactive oxygen species formation during human SW872 cell adipogenic differentiation 165
The respiratory-chain poison antimycin A promotes the formation of DNA single-strand breaks and reduces toxicity in U937 cells exposed to tert-butylhydroperoxide. 164
Mechanism of the antimycin A-mediated enhancement of tert-butylhydroperoxide-induced single-strand breakage in DNA. 163
Opposite effects of nitric oxide donors on DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide. 160
Low Concentrations of Arsenite Target the Intraluminal Inositol 1, 4, 5-Trisphosphate Receptor/Ryanodine Receptor Crosstalk to Significantly Elevate Intracellular Ca2 159
NADH-linked substrate-mediated enhancement of mitochondrial calcium accumulation and DNA single-strand breakage elicited by tert-butylhydroperoxide: the source of the cation is a ryanodine-sensitive calcium store . 148
Effects of L-histidine on hydrogen peroxide-induced DNA damage and cytotoxicity in cultured mammalian cells. 144
Stimulation of oxygen consumption promotes mitochondrial calcium accumulation, a process associated with, and causally linked to, enhanced formation of tert-butylhydroperoxide-induced DNA single-strand breaks. 144
Exogenous histidine as a co-factor which exacerbates the toxicity of hydrogen peroxide in cultured mammalian and bacterial cells 143
Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells 142
Nrf2-Mediated Pathway Activated by Prunus spinosa L. (Rosaceae) Fruit Extract: Bioinformatics Analyses and Experimental Validation 142
Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment 139
The mechanism of the nitric oxide-mediated enhancement of tert-butylhydroperoxide-induced DNA single strand breakage. 139
Reduced mitochondrial formation of H(2)O(2) is responsible for resistance of dimethyl sufoxide differentiated U937 cells to peroxynitrite 139
Inhibition of activity/expression, or genetic deletion, of ERO1α blunts arsenite geno- and cyto-toxicity 135
The inositol 1,4,5-trisphosphate-generating agonist ATP enhances DNA cleavage induced by tert-butylhydroperoxide. 134
ERO1α primes the ryanodine receptor to respond to arsenite with concentration dependent Ca2+ release sequentially triggering two different mechanisms of ROS formation 133
Mitochondrial ROS, ER Stress, and Nrf2 Crosstalk in the Regulation of Mitochondrial Apoptosis Induced by Arsenite 126
Essential role of the mitochondrial respiratory chain in peroxynitrite-induced strand scission of genomic DNA. 123
Effects of nitric oxide on tert-butylhydroperoxide-induced DNA single-strand breakage. 119
Unveiling the Link Between NADPH Oxidase 2 Activation and Mitochondrial Superoxide Formation in Leukemic Cell Killing Induced by Arsenic Trioxide 117
Totale 22.152
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Categoria #
all - tutte 86.672
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 86.672
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022922 0 0 0 160 65 49 70 84 81 100 35 278
2022/20231.625 169 86 22 196 184 316 12 109 292 60 104 75
2023/2024534 58 35 54 81 44 137 16 20 1 37 1 50
2024/20252.273 71 134 270 85 65 204 384 218 364 127 184 167
2025/20264.825 396 475 511 761 390 304 602 153 365 474 252 142
2026/20271.255 212 114 477 452 0 0 0 0 0 0 0 0
Totale 22.773